The prevalence of mixed genotype infections in Polish patients with hepatitis C
International Journal of Infectious Diseases, 2016 Objectives: Hepatitis C virus (HCV) genotype has been described as an independent predictor of the response to therapy. A mixed infection with two types of HCV is probably an uncommon event.
Ewelina Gowin +7 more
doaj +1 more source
Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models [PDF]
, 2010 Chimpanzees represent the only animal model for studies of the natural history of hepatitis C virus (HCV). To generate virus stocks of important HCV variants, we infected chimpanzees with HCV strains of genotypes 1-6 and determined the infectivity titer ...
Bukh, Jens +11 more
core +1 more source
HCV non-1b genotypes in injecting drug users from Romania
The Journal of Infection in Developing Countries, 2016 Introduction: Chronic hepatitis C cases diagnosed in Romania were mostly related to unsafe parenteral treatments and blood transfusions; HCV genotype 1b was prevalent. During the last decade, an increasing number of HCV infections was reported among people who inject drugs (PWID).
Simona Ruta +5 more
openaire +4 more sources
Frequency distribution of hepatitis C virus genotypes in different geographical regions of Pakistan and their possible routes of transmission [PDF]
, 2008 Background Information regarding hepatitis C virus genotypes and subtypes circulating in Pakistan and various risk factors for their transmission are not known well.
Riazuddin Sheikh, Idrees Muhammad
core +1 more source
O-GlcNAcase contributes to cognitive function in Drosophila [PDF]
, 2020 Contains fulltext : 219183.pdf (publisher's version ) (Open ...
Catinozzi, Marica +7 more
core +3 more sources
Вопросы вирусологии, 2017 The main reason for the ineffectiveness of antiviral therapy in patients with chronic hepatitis C that impedes full and adequate treatment of IFN-α and ribavirin is the development of neutropenia and thrombocytopenia.
E. R. Manapova +2 more
doaj +1 more source
Genotype-specific versus pangenotypic regimens in patients infected with HCV genotype 1b in real-world settings [PDF]
Polish Archives of Internal Medicine, 2021 Introduction The introduction of direct-acting antivirals (DAA) has provided us with hope to eliminate hepatitis C virus (HCV) infection as a significant public health problem in the coming years. Objective Our study aimed to compare the effectiveness and safety between genotype-specific and pangenotypic regimens in GT1b infected patients treated in
Paweł Pabjan +9 more
openaire +1 more source
The role of different virus genotypes in progression of chronic hepatitis C [PDF]
Vojnosanitetski Pregled, 2002 The relation between HCV genotypes and the progression of chronic hepatitis is still unknown. Some studies implied more pathogenic effect of genotype 1b for the severity of liver inflammation.
Nožić Darko +4 more
doaj +1 more source
NS5A Resistance-Associated Substitutions in Patients with Genotype 1 Hepatitis C Virus:Prevalence and Effect on Treatment Outcome [PDF]
, 2017 Background & Aims The efficacy of NS5A inhibitors for the treatment of patients chronically infected with hepatitis C virus (HCV) can be affected by the presence of NS5A resistance-associated substitutions (RASs).
Brainard, Diana M +19 more
core +2 more sources
Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents [PDF]
, 2014 Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes.
A Owsianka +72 more
core +7 more sources