Results 51 to 60 of about 380,405 (282)

Development of a Method for Screening and Genotyping of HCV 1a, 1b, 2, 3, 4, and 6 Genotypes [PDF]

ACS Omega, 2020
The World Health Organization and the World Health Assembly recommended eradicating hepatitis as a public threat by 2030. The accurate genotyping of hepatitis C virus (HCV) is crucial to achieving this goal because it is vital for the selection of anti-HCV therapy required for complete cure of HCV infection.
Shrikant Dashrath Warkad, Satish Balasaheb Nimse, Keum-Soo Song, Taisun Kim   +3 more
openaire   +3 more sources

Cell culture replication of a genotype 1b hepatitis C virus isolate cloned from a patient who underwent liver transplantation. [PDF]

PLoS ONE, 2011
The introduction of the genotype 2a isolate JFH1 was a major breakthrough in the field of hepatitis C virus (HCV), allowing researchers to study the complete life cycle of the virus in cell culture.
George Koutsoudakis, Sofia Perez-del-Pulgar, Mairene Coto-Llerena, Patricia Gonzalez, Jakub Dragun, Laura Mensa, Gonzalo Crespo, Miguel Navasa, Xavier Forns   +8 more
doaj   +1 more source

Epidemiology and Genotype Distribution of Hepatitis C Virus in Russia

Pathogens, 2022
The hepatitis C virus (HCV) causes both acute and chronic infection of the liver that can lead to liver cirrhosis, cancer, and liver failure. HCV is characterized by high genetic diversity and substantial variations in the prevalence of specific HCV ...
Nikolay Pimenov, Dmitry Kostyushev, Svetlana Komarova, Anastasia Fomicheva, Alexander Urtikov, Olga Belaia, Karina Umbetova, Olga Darvina, Natalia Tsapkova, Vladimir Chulanov   +9 more
doaj   +1 more source

Complete replication of hepatitis C virus in cell culture. [PDF]

, 2005
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
Burton, Dennis R, Evans, Matthew J, Hynes, Richard O, Lindenbach, Brett D, Liu, Christopher C, Maruyama, Toshiaki, McKeating, Jane A, Rice, Charles M, Syder, Andrew J, Tellinghuisen, Timothy L, Wölk, Benno   +10 more
core   +1 more source

Replication and infectivity of a novel genotype 1b hepatitis C virus clone [PDF]

Microbiology and Immunology, 2012
ABSTRACT Hepatitis C virus infection is a major public health problem because of an estimated 170 million carriers worldwide. Genotype 1b is the major subtype of HCV in many countries and is resistant to interferon therapy. Study of the viral life cycle is important for understanding the mechanisms of interferon resistance of genotype 1b HCV strains ...
Tomoko, Date, Kenichi, Morikawa, Yasuhito, Tanaka, Keiko, Tanaka-Kaneko, Tetsutaro, Sata, Masashi, Mizokami, Takaji, Wakita   +6 more
openaire   +2 more sources

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T., Baillie, G.S., Canton, D.A., Day, J.P., Gelman, I.H., Grimes, Q., Guercio, L.A., Havekes, R., Huang, T., Luczak, V., Nie, T., Park, A.J., Scott, J.D.   +12 more
core   +2 more sources

Recurrent hepatitis C genotype 1b following liver transplantation

European Journal of Gastroenterology & Hepatology, 2004
Recurrent hepatitis C is very common leading to graft cirrhosis in a significant proportion of patients. Preliminary reports of combination therapy with interferon-ribavirin have been promising but generally applied to selected patients with chronic mild disease.
Berenguer, M, Prieto, M, Palau, A, Carrasco, D, Rayon, JM, Calvo, F, Berenguer, J   +6 more
openaire   +3 more sources

Hepatitis C virus genotype 1b increases cumulative lifetime risk of hepatocellular carcinoma [PDF]

International Journal of Cancer, 2014
The association between subtypes of hepatitis C virus (HCV) and risk of hepatocellular carcinoma (HCC) remained inconclusive and evaluated in both case–control and cohort studies. In the case–control study, 397 HCC cases from medical centers were compared with 410 community‐based non‐HCC controls.
Mei-Hsuan, Lee, Hwai-I, Yang, Sheng-Nan, Lu, Chin-Lan, Jen, San-Lin, You, Li-Yu, Wang, Gilbert, L'Italien, Chien-Jen, Chen, Yong, Yuan   +8 more
openaire   +2 more sources

An infectious molecular clone of a Japanese genotype 1b hepatitis C virus [PDF]

Hepatology, 1999
We describe an infectious molecular clone of a Japanese genotype 1b strain of hepatitis C virus (HCV-N). The molecularly cloned sequence of HCV-N was compared with alignments of other HCV sequences, leading to the identification of 15 unique, nonconservative amino acid substitutions within the HCV-N open reading frame (ORF ...
M R, Beard, G, Abell, M, Honda, A, Carroll, M, Gartland, B, Clarke, K, Suzuki, R, Lanford, D V, Sangar, S M, Lemon   +9 more
openaire   +2 more sources

Molecular Methods for Rare Hemoglobinopathy Cases: First Brazilian Report of Pediatric Siblings with Hb O‐Arab and Alpha‐Thalassemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk, Amanda Cristina Meneguetti Berti, Bárbara Braga Vieira Marques, Victoria Simões Bernardo, Flaviene Felix Torres, Ingrid Souza Dias, Vanessa da Silveira Ramos de Castro, Gabriela Alves Bernardino, Danilo Grünig Humberto da Silva, Edis Belini‐Júnior   +9 more
wiley   +1 more source