Results 81 to 90 of about 59,169,857 (243)

Genotyping-By-Sequencing applications in biology

open access: yes, 2017
Genotyping-by-Sequencing (GBS) is a method used to develop rapid and cost-effective high-density genetic marker data for diverse applications in biology.
Shannon Clarke (3504989)   +14 more
core  

Analysis methods for low-depth genotyping-by-sequencing data

open access: yes, 2020
Outline -- Genotyping-By-Sequencing -- QC / filtering -- Relatedness & Parentage -- Allele sampling models -- Population Genetics -- Hardy-Weinberg -- FST -- Student’s ...
Ken Dodds (3501542)
core  

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

open access: yesFEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa   +4 more
wiley   +1 more source

Quantitative Genetic Mapping and Genome Assembly in the Lesser Wax Moth Achroia grisella

open access: yesG3: Genes, Genomes, Genetics, 2019
Specific characteristics of the male Achroia grisella acoustic mating signal determine a male’s attractiveness toward females. These features are genetically variable in populations, and mapping experiments have been used to identify loci contributing to
Boryana S. Koseva   +7 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

Population genetics and phylogeographic history of the insular lizard Podarcis lilfordi (Gunther, 1874) from the Balearic Islands based on genome‐wide polymorphic data

open access: yesEcology and Evolution
Islands provide a great system to explore the processes that maintain genetic diversity and promote local adaptation. We explored the genomic diversity of the Balearic lizard Podarcis lilfordi, an endemic species characterized by numerous small insular ...
Katherin Otalora   +6 more
doaj   +1 more source

HLA genotyping by next-generation sequencing of complementary DNA

open access: yesBMC Genomics, 2017
Background Genotyping of the human leucocyte antigen (HLA) is indispensable for various medical treatments. However, unambiguous genotyping is technically challenging due to high polymorphism of the corresponding genomic region.
Hidenobu Segawa   +2 more
doaj   +1 more source

Comparison of relatedness from SNP chips and genotyping-by-sequencing

open access: yes, 2017
Estimates of genomic relatedness derived from either SNP chip (two different densities) or genotyping-by-sequencing (GBS) resources were compared in a group of 95 sheep.
Ken Dodds (3501542)   +4 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

An investigation of allele sampling models for genotyping-by-sequencing

open access: yes, 2018
Genotyping-by-sequencing (GBS) produces data suitable for genomic analysis such as genomic selection or parentage analysis. Analyses are improved when models which incorporate facets of the genotyping process are taken into account, for example the read ...
Ken Dodds (3501542)   +3 more
core  

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