Results 91 to 100 of about 55,908,906 (258)

Bioinformatics' approaches to detect genetic variation in whole genome sequencing data [PDF]

, 2010
Current genetic marker repositories are not sufficient or even are completely lacking for most farm animals. However, genetic markers are essential for the development of a research tool facilitating discovery of genetic factors that contribute to ...
Kerstens, H.H.D.
core  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Genotyping-by-Sequencing: efficiency and reproducibility checks

, 2015
Genotyping-by-Sequencing (GBS) has the potential to be a cost effective, reproducible and high-throughput SNP genotyping method. We have been investigating GBS in a number of livestock species, with an emphasis on Sheep.
Rudiger Brauning (47247), Ken Dodds (3501542), Shannon Clarke (3504989), John McEwan (45371), Tracey Van Stijn (10380614)   +4 more
core  

Breeding Low Emitting Ruminants: Predicting Methane from Microbes

Proceedings, 2020
The greatest source of global anthropogenic methane (CH4) emissions is from ruminant livestock. Multiple mitigation strategies in livestock are currently being explored.
Suzanne J. Rowe, Melanie Hess, Larissa Zetouni, Sharon Hickey, Rudiger Brauning, Hannah Henry, Holly Flay, Juliana Budel, Brooke Bryson, Peter Janssen, Arjan Jonker, John McEwan   +11 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Genotyping-by-Sequencing - Development in livestock

, 2015
Recent advances in next generation sequencing technology have increased the output/cost to a level that where genotyping-by-sequencing (GBS) in livestock and plant crops as well as aquaculture species can be considered. GBS has the potential to be a cost
Rudiger Brauning (47247), Ken Dodds (3501542), Shannon Clarke (3504989), John McEwan (45371), Tracey Van Stijn (10380614)   +4 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Genotyping-by-Sequencing application in Chinook Salmon

, 2016
Genomics and DNA sequencing technologies are rapidly advancing to the point where they can be cost effectively applied within aquaculture breeding programmes.
Hayley Baird (8845760), Shannon Clarke (3504989), Rachael Ashby (15393782), Jane Symonds (3577784), Jon Bailey (3695284), Mark Preece (15394256)   +5 more
core  

Genetic diversity analysis of lettuce using genotyping-by-sequencing

, 2021
Genome-wide SNP discovery and population structure analysis in lettuce (Lactuca Sativa) were conducted using genotyping by ...
Beiquan Mou USDA (17856947), European Bioinformatics Institute (17856512), Pawan Kumar USDA (17856950)   +2 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source