Results 101 to 110 of about 179,331 (298)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Genotyping-by-sequencing (GBS): a novel, efficient and cost-effective genotyping method for cattle using next-generation sequencing. [PDF]

PLoS ONE, 2013
High-throughput genotyping methods have increased the analytical power to study complex traits but high cost has remained a barrier for large scale use in animal improvement. We have adapted genotyping-by-sequencing (GBS) used in plants for genotyping 47
Marcos De Donato, Sunday O Peters, Sharon E Mitchell, Tanveer Hussain, Ikhide G Imumorin   +4 more
doaj   +1 more source

Genomic Selection in Wheat Breeding using Genotyping‐by‐Sequencing

The Plant Genome, 2012
Genomic selection (GS) uses genomewide molecular markers to predict breeding values and make selections of individuals or breeding lines prior to phenotyping. Here we show that genotyping‐by‐sequencing (GBS) can be used for de novo genotyping of breeding panels and to develop accurate GS models, even for the large, complex, and ...
Poland, Jesse A., Endelman, Jeffrey, Dawson, Julie, Rutkoski, Jessica, Wu, Shuangye, Manes, Yann, Dreisigacker, Susanne, Crossa, José, Sánchez-Villeda, Héctor, Sorrells, Mark, Jannink, Jean-Luc   +10 more
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Genome-wide SNP discovery and population structure analysis in pepper (Capsicum annuum) using genotyping by sequencing [PDF]

, 2016
BACKGROUND: Knowledge on population structure and genetic diversity in vegetable crops is essential for association mapping studies and genomic selection.
Cardi, T., D'Agostino, N., Greco, B., Taranto, F., Tripodi, P.   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genetic Diversity and Population Structure of the USDA Sweetpotato (Ipomoea batatas) Germplasm Collections Using GBSpoly

Frontiers in Plant Science, 2018
Sweetpotato (Ipomoea batatas) plays a critical role in food security and is the most important root crop worldwide following potatoes and cassava. In the United States (US), it is valued at over $700 million USD.
Phillip A. Wadl, Bode A. Olukolu, Bode A. Olukolu, Sandra E. Branham, Robert L. Jarret, G. Craig Yencho, D. Michael Jackson   +6 more
doaj   +1 more source

Genome-wide association study identified candidate genes controlling continuous storage root formation and bulking in hexaploid sweetpotato

BMC Plant Biology, 2020
Background Continuous storage root formation and bulking (CSRFAB) in sweetpotato is an important trait from agronomic and biological perspectives. Information about the molecular mechanisms underlying CSRFAB traits is lacking.
Astère Bararyenya, Bode A. Olukolu, Phinehas Tukamuhabwa, Wolfgang J. Grüneberg, Wellington Ekaya, Jan Low, Mildred Ochwo-Ssemakula, Thomas L. Odong, Herbert Talwana, Arfang Badji, Martina Kyalo, Yao Nasser, Dorcus Gemenet, Mercy Kitavi, Robert O. M. Mwanga   +14 more
doaj   +1 more source

Breeding Low Emitting Ruminants: Predicting Methane from Microbes

Proceedings, 2020
The greatest source of global anthropogenic methane (CH4) emissions is from ruminant livestock. Multiple mitigation strategies in livestock are currently being explored.
Suzanne J. Rowe, Melanie Hess, Larissa Zetouni, Sharon Hickey, Rudiger Brauning, Hannah Henry, Holly Flay, Juliana Budel, Brooke Bryson, Peter Janssen, Arjan Jonker, John McEwan   +11 more
doaj   +1 more source

Marker-assisted backcrossing for introgression of the saltol locus conferring salt stress tolerance in rice. [PE0856] [PDF]

, 2020
Soil salinization represents a threat for rice cultivation. The H2020 project NEURICE (New Commercial EUropean Rice) aimed at identifying and introducing genetic variation for salt tolerance in European rice germplasm, mainly by exploiting the positive ...
Brottier, Laurent, Canella, Marco, Cattivelli, Luigi, Cavallaro, Viviana, Courtois, Brigitte, Finocchiaro, Franca, Frouin, Julien, Gennaro, Massimo, Maré, Caterina, Monaco, Stefano, Samper, Patrick, Tacconi, Gianni, Tondelli, Alessandro, Valè, Giampiero, Zampieri, Elisa   +14 more
core