Results 51 to 60 of about 55,908,906 (258)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The development and characterization of a 60K SNP chip for chicken [PDF]

, 2011
Background In livestock species like the chicken, high throughput single nucleotide polymorphism (SNP) genotyping assays are increasingly being used for whole genome association studies and as a tool in breeding (referred to as genomic selection).
Vereijken, Addie, Wesley C Warren, William M Muir, Hillier LaDeana W, LaDeana W Hillier, Zare Yalda, Groenen, Martien AM, Hillier, LaDeana W, Hans H Cheng, Groenen, Martin AM, Vereijken Addie, Muir William M, Zare, Yalda, Cheng, Hans H, Groenen Martien AM, Megens, H.J.W.C., Cheng Hans H, Megens Hendrik-Jan, Ron Okimoto, Vereijken, A., Muir, W.M., Martien AM Groenen, Groenen, M.A.M., Hendrik-Jan Megens, Warren Wesley C, Crooijmans, Richard PMA, Yalda Zare, Warren, W.C., Warren, Wesley C, Zare, Y., Okimoto Ron, Cheng, H.H., Richard PMA Crooijmans, Addie Vereijken, Hillier, L.W., Okimoto, Ron, Muir, Williams M, Crooijmans, R.P.M.A., Okimoto, R., Megens, Hendrik-Jan, Muir, William M, Crooijmans Richard PMA   +41 more
core   +2 more sources

Characterization of Brassica napus L. genotypes utilizing sequence-related amplified polymorphism and genotyping by sequencing in association with cluster analysis [PDF]

Molecular Breeding, 2016
Identifying parental combinations that exhibit high heterosis is a constant target for commercial Brassica napus L. hybrid development programs. Finding high heterotic parental combinations can require hundreds of test crosses and years of yield evaluation.
Lees, Corey J., Li, Genyi, Duncan, Robert W.   +2 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Genomic Prediction in Maize Breeding Populations with Genotyping-by-Sequencing [PDF]

G3 Genes|Genomes|Genetics, 2013
Abstract Genotyping-by-sequencing (GBS) technologies have proven capacity for delivering large numbers of marker genotypes with potentially less ascertainment bias than standard single nucleotide polymorphism (SNP) arrays. Therefore, GBS has become an attractive alternative technology for genomic selection.
Crossa, Jose, Beyene, Yoseph, Kassa, Semagn, Pérez, Paulino, Hickey, John M, Chen, Charles, de Los Campos, Gustavo, Burgueño, Juan, Windhausen, Vanessa S, Buckler, Ed, Jannink, Jean-Luc, Lopez Cruz, Marco A, Babu, Raman   +12 more
openaire   +3 more sources

Chronic radiation exposure at Chernobyl shows no effect on genetic diversity in the freshwater crustacean, Asellus aquaticus thirty years on

Ecology and Evolution, 2019
Analysis of genetic diversity represents a fundamental component of ecological risk assessments in contaminated environments. Many studies have assessed the genetic implications of chronic radiation exposure at Chernobyl, generally recording an elevated ...
Neil Fuller, Alex T. Ford, Adélaïde Lerebours, Dmitri I. Gudkov, Liubov L. Nagorskaya, Jim T. Smith   +5 more
doaj   +1 more source

Continent‐wide population genomic structure and phylogeography of North America’s most destructive conifer defoliator, the spruce budworm (Choristoneura fumiferana)

Ecology and Evolution, 2020
The spruce budworm, Choristoneura fumiferana, is presumed to be panmictic across vast regions of North America. We examined the extent of panmixia by genotyping 3,650 single nucleotide polymorphism (SNP) loci in 1975 individuals from 128 collections ...
Lisa M. Lumley, Esther Pouliot, Jérôme Laroche, Brian Boyle, Bryan M. T. Brunet, Roger C. Levesque, Felix A. H. Sperling, Michel Cusson   +7 more
doaj   +1 more source

Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics

BMC Genomics, 2022
Background Cattle are considered to be the most desirable livestock by small scale farmers. In Africa, although comprehensive genomic studies have been carried out on cattle, the genetic variations in indigenous cattle from Nigeria have not been fully ...
David H. Mauki, Abdulfatai Tijjani, Cheng Ma, Said I. Ng’ang’a, Akanbi I. Mark, Oscar J. Sanke, Abdussamad M. Abdussamad, Sunday C. Olaogun, Jebi Ibrahim, Philip M. Dawuda, Godwin F. Mangbon, Rudovick R. Kazwala, Paul S. Gwakisa, Ting-Ting Yin, Yan Li, Min-Sheng Peng, Adeniyi C. Adeola, Ya-Ping Zhang   +17 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Flexible and scalable genotyping-by-sequencing strategies for population studies [PDF]

BMC Genomics, 2014
De nombreux domaines essentiels à la production et à la recherche agricoles, tels que la sélection et la cartographie des caractères chez les plantes et le bétail, nécessitent des plates-formes de génotypage robustes et évolutives. Le génotypage par séquençage (GBS) est l'une de ces méthodes très adaptées aux organismes non humains.
Christopher Heffelfinger, Christopher Fragoso, Marlene Aparecida Moreno, John D. Overton, John P. Mottinger, Hongyu Zhao, Joe Tohmé, Stephen L. Dellaporta   +7 more
openaire   +3 more sources