, 2009 Significant volumes of knowledge have been accumulated in recent years linking subtle genetic variations to a wide variety of medical disorders from Cystic Fibrosis to mental retardation.
Brand, Michael +4 more
core +2 more sources
Human streptococcus agalactiae strains in aquatic mammals and fish [PDF]
, 2013 <p>Background: In humans, Streptococcus agalactiae or group B streptococcus (GBS) is a frequent coloniser of the rectovaginal tract, a major cause of neonatal infectious disease and an emerging cause of disease in non-pregnant adults.
Crumlish, M. +7 more
core +5 more sources
Whole genome sequencing and microsatellite analysis of the Plasmodium falciparum E5 NF54 strain show that the var, rifin and stevor gene families follow Mendelian inheritance [PDF]
, 2018 Background: Plasmodium falciparum exhibits a high degree of inter-isolate genetic diversity in its variant surface antigen (VSA) families: P. falciparum erythrocyte membrane protein 1, repetitive interspersed family (RIFIN) and subtelomeric variable ...
Bruske, Ellen +2 more
core +5 more sources
Genotyping-by-sequencing performance in selected livestock species
Genomics, 2019 Application of next generation sequencing for large scale genotyping in livestock is limited by high costs and challenging data analysis process. However, available restriction enzyme-based enrichment techniques like e.g. genotyping-by-sequencing (GBS) are promising tools allowing reduction of financial outlies by a high sample multiplexing and ...
Artur, Gurgul +7 more
openaire +2 more sources
Discovery and genotyping of structural variation from long-read haploid genome sequence data [PDF]
, 2016 In an effort to more fully understand the full spectrum of human genetic variation, we generated deep single-molecule, real-time (SMRT) sequencing data from two haploid human genomes.
Boitano, Matthew +15 more
core +2 more sources
Genome-wide association studies of seven agronomic traits under two sowing conditions in bread wheat
BMC Plant Biology, 2019 Background Wheat is a cool seasoned crop requiring low temperature during grain filling duration and therefore increased temperature causes significant yield reduction.
Muhammad Jamil +8 more
doaj +1 more source
Evaluation of TypeSeq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes. [PDF]
, 2019 BackgroundHuman papillomaviruses (HPV) cause over 500 000 cervical cancers each year, most of which occur in low-resource settings. Human papillomavirus genotyping is important to study natural history and vaccine efficacy. We evaluated TypeSeq, a novel,
Boland, Joseph +20 more
core +1 more source
Construction of relatedness matrices using genotyping-by-sequencing data [PDF]
BMC Genomics, 2015 AbstractBackgroundGenotyping-by-sequencing (GBS) is becoming an attractive alternative to array-based methods for genotyping individuals for a large number of single nucleotide polymorphisms (SNPs). Costs can be lowered by reducing the mean sequencing depth, but this results in genotype calls of lower quality.
Dodds, Ken G +6 more
openaire +2 more sources
Genotyping-by-sequencing (GBS): a novel, efficient and cost-effective genotyping method for cattle using next-generation sequencing. [PDF]
PLoS ONE, 2013 High-throughput genotyping methods have increased the analytical power to study complex traits but high cost has remained a barrier for large scale use in animal improvement. We have adapted genotyping-by-sequencing (GBS) used in plants for genotyping 47
Marcos De Donato +4 more
doaj +1 more source
BMC Plant Biology, 2020 Background Continuous storage root formation and bulking (CSRFAB) in sweetpotato is an important trait from agronomic and biological perspectives. Information about the molecular mechanisms underlying CSRFAB traits is lacking.
Astère Bararyenya +14 more
doaj +1 more source