Results 51 to 60 of about 56,079,681 (305)

The development and characterization of a 60K SNP chip for chicken [PDF]

, 2011
Background In livestock species like the chicken, high throughput single nucleotide polymorphism (SNP) genotyping assays are increasingly being used for whole genome association studies and as a tool in breeding (referred to as genomic selection).
Vereijken, Addie, Wesley C Warren, William M Muir, Hillier LaDeana W, LaDeana W Hillier, Zare Yalda, Groenen, Martien AM, Hillier, LaDeana W, Hans H Cheng, Groenen, Martin AM, Vereijken Addie, Muir William M, Zare, Yalda, Cheng, Hans H, Groenen Martien AM, Megens, H.J.W.C., Cheng Hans H, Megens Hendrik-Jan, Ron Okimoto, Vereijken, A., Muir, W.M., Martien AM Groenen, Groenen, M.A.M., Hendrik-Jan Megens, Warren Wesley C, Crooijmans, Richard PMA, Yalda Zare, Warren, W.C., Warren, Wesley C, Zare, Y., Okimoto Ron, Cheng, H.H., Richard PMA Crooijmans, Addie Vereijken, Hillier, L.W., Okimoto, Ron, Muir, Williams M, Crooijmans, R.P.M.A., Okimoto, R., Megens, Hendrik-Jan, Muir, William M, Crooijmans Richard PMA   +41 more
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Chronic radiation exposure at Chernobyl shows no effect on genetic diversity in the freshwater crustacean, Asellus aquaticus thirty years on

Ecology and Evolution, 2019
Analysis of genetic diversity represents a fundamental component of ecological risk assessments in contaminated environments. Many studies have assessed the genetic implications of chronic radiation exposure at Chernobyl, generally recording an elevated ...
Neil Fuller, Alex T. Ford, Adélaïde Lerebours, Dmitri I. Gudkov, Liubov L. Nagorskaya, Jim T. Smith   +5 more
doaj   +1 more source

Continent‐wide population genomic structure and phylogeography of North America’s most destructive conifer defoliator, the spruce budworm (Choristoneura fumiferana)

Ecology and Evolution, 2020
The spruce budworm, Choristoneura fumiferana, is presumed to be panmictic across vast regions of North America. We examined the extent of panmixia by genotyping 3,650 single nucleotide polymorphism (SNP) loci in 1975 individuals from 128 collections ...
Lisa M. Lumley, Esther Pouliot, Jérôme Laroche, Brian Boyle, Bryan M. T. Brunet, Roger C. Levesque, Felix A. H. Sperling, Michel Cusson   +7 more
doaj   +1 more source

Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics

BMC Genomics, 2022
Background Cattle are considered to be the most desirable livestock by small scale farmers. In Africa, although comprehensive genomic studies have been carried out on cattle, the genetic variations in indigenous cattle from Nigeria have not been fully ...
David H. Mauki, Abdulfatai Tijjani, Cheng Ma, Said I. Ng’ang’a, Akanbi I. Mark, Oscar J. Sanke, Abdussamad M. Abdussamad, Sunday C. Olaogun, Jebi Ibrahim, Philip M. Dawuda, Godwin F. Mangbon, Rudovick R. Kazwala, Paul S. Gwakisa, Ting-Ting Yin, Yan Li, Min-Sheng Peng, Adeniyi C. Adeola, Ya-Ping Zhang   +17 more
doaj   +1 more source

Analysis of Genotyping-by-Sequencing (GBS) Data

, 2016
The development of genotyping-by-sequencing (GBS) to rapidly detect nucleotide variation at the whole genome level, in many individuals simultaneously, has provided a transformative genetic profiling technique. GBS can be carried out in species with or without reference genome sequences yields huge amounts of potentially informative data.
Kagale, Sateesh, Koh, Chushin, Clarke, Wayne E., Bollina, Venkatesh, Parkin, Isobel A. P., Sharpe, Andrew G.   +5 more
openaire   +4 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Next Generation Characterisation of Cereal Genomes for Marker Discovery

Biology, 2013
Cereal crops form the bulk of the world’s food sources, and thus their importance cannot be understated. Crop breeding programs increasingly rely on high-resolution molecular genetic markers to accelerate the breeding process.
Paul Visendi, Jacqueline Batley, David Edwards   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source