Results 121 to 130 of about 2,762 (157)

The Golden Card of Interleukin-1 Blockers in Systemic Inflammasomopathies of Childhood. [PDF]

Int J Mol Sci
Rigante D.
europepmc   +1 more source

The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease. [PDF]

Bone Res
Muehlebach ME, Holstein SA.
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Mononuclear phagocyte morphological response to chemoattractants is dependent on geranylgeranyl pyrophosphate.

Am J Physiol Endocrinol Metab
Krauklis SA, Hussain J, Murphy KM, Dray EL, Ousley CG, Justyna K, Distefano MD, Steelman AJ, McKim DB.   +8 more
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Geranylgeranyl Diphosphate-Based Inhibitors of Post-Translational Geranylgeranylation of Cellular Proteins

Journal of Medicinal Chemistry, 1996
A novel series of stable analogs of geranylgeranyl diphosphate (GGdP) are described in which the biologically labile diphosphate moiety of GGdP is replaced by portions that can act as stable isosters. The compounds inhibited the geranylgeranyltransferase activity in whole PC-3 prostate cancer cells, as determined by the inhibition of post-translational
MACCHIA, MARCO, JANNITTI N, GERVASI G, DANESI, ROMANO   +3 more
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Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo

Journal of Genetics and Genomics, 2021
Vascular development is essential for the establishment of the circulatory system during embryonic development and requires the proliferation of endothelial cells. However, the underpinning regulatory mechanisms are not well understood. Here, we report that geranylgeranyl pyrophosphate (GGPP), a metabolite involved in protein geranylgeranylation, plays
Danyang Chong, Zhong Chen, Shan Guan, Tongyu Zhang, Na Xu, Yue Zhao, Chaojun Li   +6 more
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Inhibitors of Protein: Geranylgeranyl Transferases

Current Medicinal Chemistry, 2006
The enzyme protein:geranylgeranyl transferase-1 (PGGT-1 or GGTase-I) catalyzes the geranylgeranylation of cysteine residues near the C-termini of a variety of proteins, including most monomeric GTP binding precursor proteins belonging to the Rho, Rac and Rap subfamilies.
Farid, El Oualid, Louis H, Cohen, Gijs A, van der Marel, Mark, Overhand   +3 more
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Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity

Bioorganic & Medicinal Chemistry Letters, 2003
Phosphonoacetamido(oxy) groups have proven to be good mimics of the diphosphate portion in geranylgeranyl protein transferase I (GGTase I) inhibitors. The introduction of small alkyl groups (Me, Et) into the diphosphate mimic moiety caused a further decrease in collateral farnesyl protein transferase (FTase) inhibitory activity, thereby improving ...
Filippo, Minutolo, Simone, Bertini, Laura, Betti, Romano, Danesi, Gianbattista, Gervasi, Gino, Giannaccini, Chiara, Papi, Giorgio, Placanica, Silvia, Barontini, Simona, Rapposelli, Marco, Macchia   +10 more
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Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase

Biochemical and Biophysical Research Communications, 2007
A primary cellular target of the clinical nitrogenous bisphosphonates is the isoprenoid biosynthetic pathway. Specifically these drugs inhibit the enzyme farnesyl pyrophosphate synthase and deplete cells of larger isoprenoids. Inhibition of this enzyme results in impaired processing of both farnesylated and geranylgeranylated proteins.
Andrew J, Wiemer, Huaxiang, Tong, Kelly M, Swanson, Raymond J, Hohl   +3 more
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Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

Il Farmaco, 2004
The diphosphate moiety of geranylgeranyldiphosphate (GGdP) was replaced with metabolically and hydrolytically stable analogous polar portions, in an attempt to obtain new geranylgeranyltransferase (GGTase) inhibitors, which could also be selective over congener enzyme farnesyltransferase (FTase).
MINUTOLO, FILIPPO, M. ANTONELLO, S. BARONTINI, BERTINI, SIMONE, BETTI, LAURA, DANESI, ROMANO, G. GERVASI, GIANNACCINI, GINO, C. PAPI, PLACANICA, GIORGIO, RAPPOSELLI, SIMONA, MACCHIA, MARCO   +11 more
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