Results 1 to 10 of about 24,196 (383)

Epigenetic markers in the embryonal germ cell development and spermatogenesis [PDF]

Basic and Clinical Andrology, 2023
Résumé La spermatogenèse est le processus de génération de cellules reproductrices mâles à partir de cellules souches spermatogoniales, dans l’épithélium séminifère du testicule.
Amadeusz Odroniec, Marta Olszewska, Maciej Kurpisz   +2 more
doaj   +5 more sources

Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition [PDF]

PLoS ONE, 2012
Testicular Germ Cell Tumors (TGCT) and patient-derived cell lines are extremely sensitive to cisplatin and other interstrand cross-link (ICL) inducing agents.
Francesca Cavallo, Grazia Graziani, Cristina Antinozzi, Darren R. Feldman, Jane Houldsworth, George J. Bosl, R. S. K. Chaganti, Mary Ellen Moynahan, Maria Jasin, Marco Barchi   +9 more
semanticscholar   +8 more sources

The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas

Molecular Oncology, 2021
Testicular germ cell tumors (GCTs) are stratified into seminomas and nonseminomas. Seminomas share many histological and molecular features with primordial germ cells, whereas the nonseminoma stem cell population—embryonal carcinoma (EC)—is pluripotent ...
Daniel Nettersheim
semanticscholar   +4 more sources

Survival of Testicular Pure Embryonal Carcinoma vs. Mixed Germ Cell Tumor Patients across All Stages [PDF]

Medicina, 2023
Background and Objectives: The impact of pure histological subtypes in testicular non-seminoma germ cell tumors on survival, specifically regarding pure embryonal carcinoma, is not well established.
Cristina Cano Garcia, Andrea Panunzio, Stefano Tappero, Mattia Luca Piccinelli, Francesco Barletta, Reha-Baris Incesu, Kyle W. Law, Lukas Scheipner, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Derya Tilki, Alberto Briganti, Ottavio De Cobelli, Carlo Terrone, Alessandro Antonelli, Severine Banek, Luis A. Kluth, Felix K. H. Chun, Pierre I. Karakiewicz   +19 more
doaj   +2 more sources

OC06.05: Clinical and ultrasound characteristics of adnexal embryonal carcinomas, non‐gestational choriocarcinomas and malignant mixed germ cell tumours [PDF]

Ultrasound in Obstetrics and Gynecology, 2020
H. Verschuere1, W. Froyman1,2, T. Van den Bosch1,2, M. Van Hoefs2, J. Kaijser3, D. Van Schoubroeck1,2, A. Van Rompay4, I. Vergote1,5, D. Timmerman1,2 1Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; 2Department of ...
F. Moro, L. Castellano, D. Franchi, E. Epstein, D. Fischerová, Wouter Froyman, D. Timmerman, L. Valentin, A. C. Testa, F. Mascilini   +9 more
openalex   +2 more sources

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation [PDF]

Stem Cell Research, 2018
Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate.
Joanna J. Gell, Jasmine Zhao, Di Chen, Timothy J. Hunt, Amander T. Clark   +4 more
doaj   +4 more sources

Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report

OncoTargets and Therapy, 2018
Malignant mixed ovarian germ cell tumors are very rare, accounting for ~5.3% of all malignant ovarian germ cell tumors (MOGCTs), with a very high degree of malignancy.
Yao Wang, Jiaxin Yang, Mei Yu, Dongyan Cao, Keng Shen   +4 more
openalex   +3 more sources

Expression and therapeutic potential of TROP2 in cisplatin-resistant germ cell tumors. [PDF]

J Cancer Res Clin Oncol
Cisplatin-based chemotherapy remains the standard of care for metastatic germ cell tumors (GCTs), but patients with cisplatin-refractory disease have limited effective options and poor outcomes.
Sperber L, von Brandenstein M, Kessler C, Heidenreich J, Storz E, Pfister D, Paffenholz P, Tolkach Y, Bernhardt M, Wirtz R, Eckstein M, Heidenreich A, Weiten R.   +12 more
europepmc   +2 more sources

Pure Embryonal Cell Carcinoma: A Rare Entity [PDF]

Journal of Clinical and Diagnostic Research, 2023
Malignancy of the testes constitutes only one percent of all male cancers. Most testicular malignancies are Germ Cell Tumours (GCTs), which are broadly categorised into seminomatous and non-seminomatous types. Non seminomatous GCTs are further classified
Neha Jaiswal, Anita Sajjanar, Vaishnavi Mishra   +2 more
doaj   +2 more sources

Imaging in gynecological disease (22): clinical and ultrasound characteristics of ovarian embryonal carcinomas, non‐gestational choriocarcinomas and malignant mixed germ cell tumors [PDF]

Ultrasound in Obstetrics and Gynecology, 2020
To describe the clinical and ultrasound characteristics of three types of rare malignant ovarian germ cell tumor: embryonal carcinoma, non‐gestational choriocarcinoma and malignant mixed germ cell tumor.
F. Moro, L. Castellano, D. Franchi, E. Epstein, D. Fischerová, Wouter Froyman, D. Timmerman, Gianfranco Zannoni, Giovanni Scambia, L. Valentin, A. C. Testa, F. Mascilini   +11 more
openalex   +2 more sources