Results 91 to 100 of about 24,196 (383)

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma [PDF]

, 2017
Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. Seminomas are similar to carcinoma in situ (CIS) cells, the common precursor of type II GCCs, with regard to epigenetics and expression, while embryonal carcinomas (EC ...
Esteller, Manel, Ferreira, Humberto J., Hoffmann, Per, Hofmann, Andrea, Jostes, Sina, Kristiansen, Glen, Nettersheim, Daniel, Schneider, Simon, Schorle, Hubert, Sharma, Rakesh   +9 more
core   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Bilateral Synchronous Testis Tumors of Different Histology: A Case Report

Caspian Journal of Internal Medicine, 2020
Background: Bilateral synchronous testis germ cell tumors with different histopathology are not common. Case Presentation: Here, a case of 27-year-old male who is reported presented with bilateral testicular swellings.
Ghasem Rostami, Hamid Shafi, Mohammad Ranaee, Samaneh Saeedfar, Fatemeh Mahmodloo   +4 more
doaj  

Mixed Germ Cell Tumor of the Endometrium: A Case Report and Literature Review

Open Medicine, 2020
Germ cell tumors (GCTs) localized extragonadally are rare, with only 14 reported cases of a yolk sac tumor in the endometrium. Here we report a case of mixed endometrium GCTs in a 65-year-old postmenopausal woman with abnormal vaginal bleeding.
Heping Zhang, Fa-wen Liu, Jianguo Wei, Debin Xue, Zhengxin Xie, Chun-wei Xu   +5 more
semanticscholar   +1 more source

a report from the Children's Oncology Group and the Utah Population Database [PDF]

, 2015
Relatively little is known about the epidemiology and factors underlying susceptibility to childhood rhabdomyosarcoma (RMS). To better characterize genetic susceptibility to childhood RMS, we evaluated the role of family history of cancer using data from
Curtin, Karen, Danysh, Heather E., Erhardt, Erik B., Grufferman, Seymour, Hawkins, Douglas S., Hettmer, Simone, Lupo, Philip J., Malkin, David, Melin, Beatrice, Papworth, Karin, Plon, Sharon E., Schiffman, Joshua D., Skapek, Stephen X., Spector, Logan G.   +13 more
core   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours

BMC Cancer, 2020
Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors.
K. Poulsen, J. Nielsen, B. Toft, U. N. Joensen, L. Rasmussen, M. Jensen, R. Mitchell, A. Juul, E. R. Meyts, A. Jørgensen   +9 more
semanticscholar   +1 more source

Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas [PDF]

, 2013
Cancer/Testis (CT) antigens are normally only expressed in germ cells and yet are aberrantly activated in a wide variety of human cancers. Most chromosome X-encoded CT antigens (CT-X) show restricted expression in pre-meiotic germ cells in adult testis ...
Cao, Dengfeng, Chen, Yao-Tseng, Chiu, Rita, Lee, Peishan   +3 more
core   +2 more sources

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Cell Germ primary tumor of mediastinum (seminoma of mediastinum)

Archivo Médico de Camagüey, 2019
Background: the anterior mediastinal germ cell tumor is a formation of neoplastic cells located in the mediastinum. They are formed by congenital defects in the embryonic stage by migration of the primordial germ cell and dermal cells that are within the
René Hernández-Benedicto, Rafael Pila-Pérez, Pedro Rosales-Torres   +2 more
doaj