PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation [PDF]
Stem Cell Research, 2018 Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate.
Joanna J. Gell +4 more
doaj +4 more sources
A teratocarcinoma-like human embryonic stem cell (hESC) line and four hESC lines reveal potentially oncogenic genomic changes [PDF]
, 2010 The first Swiss human embryonic stem cell (hESC) line, CH-ES1, has shown features of a malignant cell line. It originated from the only single blastomere that survived cryopreservation of an embryo, and it more closely resembles teratocarcinoma lines ...
Outi Hovatta +15 more
core +14 more sources
Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors [PDF]
, 2016 Type II germ cell tumors arise after puberty from a germ cell that was incorrectly programmed during fetal life. Failure of testicular germ cells to properly differentiate can lead to the formation of germ cell neoplasia in situ of the testis; this ...
Bowles, J. (Josephine) +6 more
core +1 more source
Reproductive Biology and Endocrinology, 2009 Background Estrogens exert a role on germ cell physiology of normal human testis through the mediation of the estrogen receptor (ER) beta subtypes. Epidemiological studies evidenced an increased incidence of testicular germ cell cancer after elevated pre-
Rago Vittoria +5 more
doaj +1 more source
Treatment of clinical stage I non-seminoma
Asian Journal of Urology, 2021 Germ cell cancers are the most common solid tumors among men between 15 and 40 years. Non-seminomatous germ cell tumors (NSGCTs) represent a unique and exclusive cohort of germ cell tumor patients. Non-seminoma can harbor different histologic components.
Christian Winter, Andreas Hiester
doaj +1 more source
Dysgerminoma with Embryonal Carcinoma, a Rare Ovarian Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl: A Case Report [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i ĪrānIntroduction: Pediatric patients rarely develop ovarian tumors, but mainly develop ovarian germ cell tumors. Malignant germ cell tumors are generally rare and dysgerminoma is the most frequent malignant ovarian neoplasm in young and adolescent girls.
Mahsa Akbari Oryani +3 more
doaj +1 more source
The histologic features of intratubular germ cell neoplasia and its correlation with tumor behavior [PDF]
Investigative and Clinical Urology, 2016 Purpose: To assess the prevalence of intratubular germ cell neoplasia (ITGCN) in patients with concurrent testis tumor and its correlation with histologic features and serum tumor markers.
Abbas Basiri +4 more
doaj +1 more source
Identification of side population cells in mouse primordial germ cells and prenatal testis [PDF]
, 2011 In mammals, the stem cells of spermatogenesis are derived from an embryonic cell population called primordial germ cells (PGCs). Spermatogonial stem cells displaying the "side population" (SP) phenotype have been identified in the immature and adult ...
De Felici, Massimo +6 more
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Cell Reports, 2017 Summary: Testicular germ cell tumors (TGCTs) are among the most responsive solid cancers to conventional chemotherapy. To elucidate the underlying mechanisms, we developed a mouse TGCT model featuring germ cell-specific Kras activation and Pten ...
Timothy M. Pierpont +15 more
doaj +1 more source
Exploring the interdependencies of research funders in the UK [PDF]
, 2014 Investment in medical research is vital to the continuing improvement of the UK's health and wealth. It is through research that we expand our understanding of disease and develop new treatments for patients.
Crane, P +13 more
core +1 more source