Spatial organization of translation and translational repression in two phases of germ granules [PDF]
Nature CommunicationsMost RNA-protein condensates are composed of heterogeneous immiscible phases. However, how this multiphase organization contributes to their biological functions remains largely unexplored.
Anne Ramat +3 more
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Germ granule-mediated mRNA storage and translational control
RNA BiologyGerm cells depend on specialized post-transcriptional regulation for proper development and function, much of which is mediated by dynamic RNA granules.
Hoang-Anh Pham-Bui, Mihye Lee
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Germ Cell Responses to Stress: The Role of RNP Granules [PDF]
Frontiers in Cell and Developmental Biology, 2019 The ability to respond to stress is critical to survival for animals. While stress responses have been studied at both organismal and cellular levels, less attention has been given to the effect of stress on the germ line. Effective germ line adaptations
Jennifer A. Schisa
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Rbm24a dictates mRNA recruitment for germ granule assembly in zebrafish
The EMBO JournalThe germ granules are ribonucleoprotein (RNP) biomolecular condensates that determine the fate of primordial germ cells (PGCs) and serve as a model for studying RNP granule assembly.
Yizhuang Zhang +16 more
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Germ granule localization of nematode Argonaute WAGO-4 ensures fidelity in small RNA loading [PDF]
The EMBO JournalGerm granules are liquid-like condensates that regulate small RNA pathways and gene expression, ensuring genome stability and fertility in animals. In C.
Stela Jelenic +8 more
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Retraction Notice to: Maternal dazap2 Regulates Germ Granules by Counteracting Dynein in Zebrafish Primordial Germ Cells. [PDF]
Cell Rep, 2016 (Cell Reports 12, 49–57; July 7, 2015)The first author, a graduate student, has admitted orally and in writing to fabrication of data that she contributed to this article in which we reported a maternal requirement for the scaffold protein Dazap2 (Mdazap2) in germ granule maintenance by a mechanism that is epistatic to Tdrd7 and that counteracts Dynein
Forbes MM +3 more
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Germ granules in spermatogenesis of Drosophila: Evidences of contribution to the piRNA silencing. [PDF]
Commun Integr Biol, 2012 Ribonucleoprotein-containing granules in the cytoplasm of germinal cells are known to be a common attribute of eukaryotic organisms. Germ granules appear to ensure the posttranscriptional regulation of germline mRNAs. Recent studies specify the participation of the germ granules in genome integrity maintenance by mechanisms involving short piRNAs. PIWI
Kibanov MV, Gvozdev VA, Olenina LV.
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Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos
Developmental Biology, 2008 In somatic cells, untranslated mRNAs accumulate in cytoplasmic foci called processing bodies or P-bodies. P-bodies contain complexes that inhibit translation and stimulate mRNA deadenylation, decapping, and decay. Recently, certain P-body proteins have been found in germ granules, RNA granules specific to germ cells.
Gallo, Christopher M. +4 more
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Multiple domains of scaffold Tudor protein play nonredundant roles in Drosophila germline [PDF]
Life Science AllianceMultiple protein–protein interaction domains nonredundantly contribute to the function of Tudor scaffold protein in formation of biomolecular condensates and germline development in Drosophila .
Samuel J Tindell +3 more
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Three lncRNAs promote PUM protein condensation and germline differentiation [PDF]
Nature CommunicationsLong non-coding RNAs (lncRNAs) are abundant in gonads, yet most knockout models show no fertility defects, leaving their role unclear. Here, we identify overlapping functions of three lncRNAs in Caenorhabditis elegans fertility.
Roni Falk +9 more
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