Results 31 to 40 of about 158,206 (306)

Neuroinflammation and myelin status in Alzheimer’s disease, Parkinson’s disease, and normal aging brains: A small sample study [PDF]

, 2019
Microglia and astrocytes play important roles in mediating the immune processes and nutritional support in the central nervous system (CNS). Neuroinflammation has been indicated in the progression of neurodegenerative diseases Alzheimer’s disease (AD ...
Benzinger, Tammie L. S., Han, Fei, Morris, John C., Perlmutter, Joel S., Perrin, Richard J., Wang, Qing, Wang, Yong, Xu, Jinbin   +7 more
core   +2 more sources

A novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury [PDF]

, 2016
Astrogliosis (i.e. glial scar), which is comprised primarily of proliferated astrocytes at the lesion site and migrated astrocytes from neighboring regions, is one of the key reactions in determining outcomes after CNS injury.
Aiba, Atsu, Gutmann, David H, Hamada, Takeshi, Ishii, Taiji, Kohmura, Eiji, Kohta, Masaaki, Kondoh, Takeshi, Kuboyama, Tomoharu, Saito, Naoaki, Shigyo, Michiko, Tohda, Chihiro, Uebi, Tatsuya, Ueyama, Takehiko   +12 more
core   +2 more sources

Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms [PDF]

Molecular Psychiatry, 2003
Glial fibrillary acidic protein (GFAP) is considered to be a highly specific marker for glia. Here, we report on the expression of GFAP in neurons in the human hippocampus. Intriguingly, this neuronal GFAP is coded by out-of-frame splice variants and its expression is associated with Alzheimer pathology.
E M, Hol, R F, Roelofs, E, Moraal, M A F, Sonnemans, J A, Sluijs, E A, Proper, P N E, de Graan, D F, Fischer, F W, van Leeuwen   +8 more
openaire   +2 more sources

FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis [PDF]

, 2007
After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously,
Barnett, S.C., Fairless, R., Frame, M.C., Montague, P., Riddell, J.S., Santos-Silva, A., Smith, G.M., Toft, A.   +7 more
core   +3 more sources

Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery. [PDF]

, 2018
Injectable hydrogels with tunable physiochemical and biological properties are potential tools for improving neural stem/progenitor cell (NSPC) transplantation to treat central nervous system (CNS) injury and disease.
Czechanski, A, Deming, TJ, Kim, JH, O'Shea, TM, Reinholdt, LG, Sofroniew, MV, Wollenberg, AL   +6 more
core   +1 more source

Alexander-disease mutation ofGFAPcauses filament disorganization and decreased solubility of GFAP [PDF]

Journal of Cell Science, 2005
Alexander disease is a fatal neurological illness characterized by white-matter degeneration and the formation of astrocytic cytoplasmic inclusions called Rosenthal fibers, which contain the intermediate filament glial fibrillary acidic protein (GFAP), the small heat-shock proteins HSP27 and αB-crystallin, and ubiquitin. Many Alexander-disease patients
Victoria C, Hsiao, Rujin, Tian, Heather, Long, Ming, Der Perng, Michael, Brenner, Roy A, Quinlan, James E, Goldman   +6 more
openaire   +2 more sources

A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome. [PDF]

, 2018
The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis.
Bacova, Maria, Bimbova, Katarina, Fedorova, Jana, Galik, Jan, Jachova, Jana, Kisucka, Alexandra, Lukacova, Nadezda, Marsala, Martin, Papcunova, Stefania, Pavel, Jaroslav, Stropkovska, Andrea, Zavacky, Peter   +11 more
core   +2 more sources

Association of Blood Biomarkers With Acute Sport-Related Concussion in Collegiate Athletes: Findings From the NCAA and Department of Defense CARE Consortium [PDF]

, 2020
Importance: There is potential scientific and clinical value in validation of objective biomarkers for sport-related concussion (SRC). Objective: To investigate the association of acute-phase blood biomarker levels with SRC in collegiate athletes.
Broglio, Steven P., Brooks, M. Alison, Cameron, Kenneth L., Campbell, Darren E., CARE Consortium Investigators, DiFiori, Jon, Duma, Stephan, Foroud, Tatiana, Gill, Jessica, Giza, Christopher C., Goldman, Joshua, Guskiewicz, Kevin, Harezlak, Jaroslaw, Houston, Megan N., Huber, Daniel L., Jackson, Jonathan C., Katz, Barry P., McAllister, Thomas W., McCrea, Michael, McGinty, Gerald, Meier, Timothy B., Mihalik, Jason, Nelson, Lindsay D., Pasquina, Paul, Rowson, Steven, Saykin, Andrew J., Svoboda, Steven J.   +26 more
core   +1 more source

Immunohistochemical detection of axonal injury in chimpanzee (Pan troglodytes) with traumatic and fatal brain injury

Macedonian Veterinary Review
Estimating the time of death after traumatic brain injury (TBI) in wildlife is a significant challenge in forensic veterinary medicine. The understanding of histopathological changes and predicting the survival time can prompt critical emergency measures
Peyman Mohammadzadeh, Ahmad Reza Baharvand, Sajjad Mohammadi, Ramin Fooladi, Kimia Azimi, Erfan Eftekhar   +5 more
doaj   +1 more source

Key astroglial markers in human liver cirrhosis of different degree: immunohistochemical study

Zaporožskij Medicinskij Žurnal, 2022
The aim of the study – determining the immunohistochemical levels of the GFAP, GS and AQP4 in different regions of the human brain in the conditions of liver cirrhosis of different degree. Materials and methods.
T. V. Shulyatnikova, V. O. Tumanskyi
doaj   +1 more source