TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Automated Assessment of Nanoparticle Influence on Giant Lipid Vesicles from Video Microscopy for Bio-Nano Interaction Studies [PDF]
, 2011 Much evidence suggests that nanoparticles affect cell membrane stability and subsequently exert toxic effects. To assess these interactions research is often conducted on lipid vesicles as substitutes for cells.
Zupanc, Jernej
core +1 more source
Bending Elasticity Modulus of Giant Vesicles Composed of Aeropyrum Pernix K1 Archaeal Lipid
Life, 2015 Thermally induced shape fluctuations were used to study elastic properties of giant vesicles composed of archaeal lipids C25,25-archetidyl (glucosyl) inositol and C25,25-archetidylinositol isolated from lyophilised Aeropyrum pernix K1 cells.
Julia Genova +4 more
doaj +1 more source
Surfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics
Communications Chemistry, 2021 The production of giant unilamellar vesicles by microfluidics commonly involves additives, which may interfere with the resultant membrane properties. Here pure lipid GUVs are prepared which exclude residual surfactants and other additives.
Naresh Yandrapalli +3 more
doaj +1 more source
Shape Deformation, Budding and Division of Giant Vesicles and Artificial Cells: A Review
Life, 2022 The understanding of the shape-change dynamics leading to the budding and division of artificial cells has gained much attention in the past few decades due to an increased interest in designing stimuli-responsive synthetic systems and minimal models of ...
Ylenia Miele +3 more
doaj +1 more source
Thermal fluctuations of the lipid membrane determine particle uptake into Giant Unilamellar Vesicles
Nature Communications, 2023 Particulates, bacteria and viruses wrap into cell membranes. Here the authors use optical tweezers, particle tracking and mathematical modelling to show that the uptake process into giant vesicles is influenced by thermal membrane fluctuations.
Yareni A. Ayala +3 more
doaj +1 more source
Membranes, 2023 Giant vesicles (GVs), which are closed lipid bilayer membranes with a diameter of more than 1 μm, have attracted attention not only as model cell membranes but also for the construction of artificial cells.
Yiting Zhang, Haruto Obuchi, Taro Toyota
doaj +1 more source
Entropy-driven segregation and budding in hybrid vesicles of binary nanoparticle amphiphiles
Giant, 2020 Self-assembly of giant building blocks beyond conventional molecules offers tremendous opportunities for the fabrication of new-generation structural materials.
Chelsey Lamar +3 more
doaj +1 more source
, 2018 The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures ...
Bryl-Gorecka, Paulina, +4 more
core +1 more source
Shape Transformations of Lipid Vesicles by Insertion of Bulky-Head Lipids. [PDF]
PLoS ONE, 2015 Lipid vesicles, in particular Giant Unilamellar Vesicles (GUVs), have been increasingly important as compartments of artificial cells to reconstruct living cell-like systems in a bottom-up fashion.
Soichiro Tsuda +4 more
doaj +1 more source