Results 51 to 60 of about 20,974 (222)

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

open access: yesAdvanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Effect of Counter Electrode in Electroformation of Giant Vesicles

open access: yesMembranes, 2011
Electroformation of cell-sized lipid membrane vesicles (giant vesicles, GVs), from egg yolk phosphatidylcholine, was examined varying the shape of the counter electrode.
Shuuhei Oana, Yukihisa Okumura
doaj   +1 more source

The Role of Membrane Fluidization in the Gel-Assisted Formation of Giant Polymersomes. [PDF]

open access: yesPLoS ONE, 2016
Polymersomes are being widely explored as synthetic analogs of lipid vesicles based on their enhanced stability and potential uses in a wide variety of applications in (e.g., drug delivery, cell analogs, etc.).
Adrienne C Greene   +5 more
doaj   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

open access: yesAdvanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian   +12 more
wiley   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

open access: yesAdvanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong   +13 more
wiley   +1 more source

Clinical periodontal diagnosis

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi   +5 more
wiley   +1 more source

Formation of Oligovesicular Vesicles by Micromanipulation

open access: yesMembranes, 2011
Cell-sized lipid bilayer membrane vesicles (giant vesicles, GVs) or semi-vesicles were formed from egg yolk phosphatidylcholine on a platinum electrode under applied electric voltage by electroformation.
Yukihisa Okumura   +2 more
doaj   +1 more source

Growing Polymer Vesicles Generated by Polymerization Induced Self-Assembly Coupled With a Living Chemical Reactor

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
Chemical oscillatory reactions have attracted intensive attention due to their autonomous, continuous, and periodic features. Herein, the radicals generated in Belousov-Zhabotinsky (BZ) oscillator was used to initiate RAFT (reversible addition ...
Zhihui Lu, Jinshan Guo
doaj   +1 more source

Chemical communication at the synthetic cell/living cell interface

open access: yesCommunications Chemistry, 2021
Synthetic models of cells are becoming increasingly sophisticated, but engineering communication between these and living cells remains challenging. Here the authors review modes of communication and signal processing between living cells and synthetic ...
Vincent Mukwaya   +2 more
doaj   +1 more source

Bulk Self-Assembly of Giant, Unilamellar Vesicles

open access: yesACS Nano, 2020
The desire to create cell-like models for fundamental science and applications has spurred extensive effort towards creating giant unilamellar vesicles (GUVs). However, a route to selectively self-assemble GUVs in bulk has remained elusive. In bulk solution, membrane-forming molecules such as phospholipids, single-tailed surfactants, and block ...
James T. Kindt   +2 more
openaire   +4 more sources

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