Results 61 to 70 of about 51,146 (259)

Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses

open access: yeseLife, 2017
Transport of synaptic vesicles (SVs) in nerve terminals is thought to play essential roles in maintenance of neurotransmission. To identify factors modulating SV movements, we performed real-time imaging analysis of fluorescently labeled SVs in giant ...
Laurent Guillaud   +2 more
doaj   +1 more source

Membrane shape as a reporter for applied forces [PDF]

open access: yes, 2008
Recent advances have enabled 3-dimensional reconstructions of biological structures in vivo, ranging in size and complexity from single proteins to multicellular structures. In particular, tomography and confocal microscopy have been exploited to capture
Antonny   +30 more
core   +2 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Unusual localization of eczema herpeticum to tinea corporis and cruris

open access: yesClinical Dermatology Review
Eczema herpeticum (EH), known as Kaposi varicelliform eruption presents with multiple vesiculopustular lesions localized to areas of preexisting eczematous or erosive dermatoses.
Soumya Narula   +3 more
doaj   +1 more source

Formation of Oligovesicular Vesicles by Micromanipulation

open access: yesMembranes, 2011
Cell-sized lipid bilayer membrane vesicles (giant vesicles, GVs) or semi-vesicles were formed from egg yolk phosphatidylcholine on a platinum electrode under applied electric voltage by electroformation.
Yukihisa Okumura   +2 more
doaj   +1 more source

Osmotic Effects Induced by Pore-Forming Agent Nystatin: From Lipid Vesicles to the Cell. [PDF]

open access: yesPLoS ONE, 2016
The responses of Chinese hamster ovary epithelial cells, caused by the pore-forming agent nystatin, were investigated using brightfield and fluorescence microscopy.
Špela Zemljič Jokhadar   +3 more
doaj   +1 more source

Clinical features of varicella-zoster virus infection [PDF]

open access: yes, 2018
Varicella-zoster virus (VZV) is a pathogenic human herpes virus that causes varicella (chickenpox) as a primary infection, following which it becomes latent in peripheral ganglia.
Gershon, Anne A., Kennedy, Peter G.E.
core   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason   +12 more
wiley   +1 more source

Electroformation of Giant Vesicles on a Polymer Mesh

open access: yesMembranes, 2011
Electroformation of cell-sized lipid membrane vesicles (giant vesicles, GVs) from egg yolk phosphatidylcholine under applied electric voltage was examined on a substrate of a polymer mesh placed between two planar indium tin oxide coated glass electrodes.
Yukihisa Okumura, Takuya Sugiyama
doaj   +1 more source

Programmed magnetic manipulation of vesicles into spatially coded prototissue architectures arrays

open access: yesNature Communications, 2020
To execute higher-order functions, cells self-assemble into spatially coded tissue configurations. Here the authors magnetically assembly giant unilamellar vesicles into three dimensional tissue-mimic structures with collective osmotic stability.
Qingchuan Li   +4 more
doaj   +1 more source

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