Results 121 to 130 of about 222,752 (301)

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

open access: yesAdvanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou   +14 more
wiley   +1 more source

The predictive effect of cultural orientations on Chinese gifted students’ growth mindsets

open access: yesFrontiers in Education
The study examined the predictive effect of cultural orientations on Chinese gifted students’ growth mindsets. This study encompassed 378 gifted students from universities in mainland China.
Huifei Jiang
doaj   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

open access: yesAdvanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang   +22 more
wiley   +1 more source

The Gifted Student: Gifts and Talents Development

open access: yesElementa. Intersections between Philosophy, Epistemology and Empirical Perspectives
Abstract  The concept of giftedness has evolved significantly over time. Today, it still lacks a singular and precise definition, but it is continually evolving. One notable model found in the literature is the Differentiated Model of Giftedness and Talent (DMGT) by Gagné. This model appears to be a valid contribution to better understanding giftedness,
Baldini, Roberta   +1 more
openaire   +2 more sources

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

open access: yesAdvanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera   +10 more
wiley   +1 more source

A Systematic Review of the Use of AI in EFL and EL Classrooms for Gifted Students

open access: yesTrends in Higher Education
There is a growing body of literature that focuses on the applicability of artificial intelligence (AI) in English as a Foreign Language (EFL) and English Language (EL) classrooms; however, educational application of AI in the EFL and EL classroom for ...
Carmen García-López   +2 more
doaj   +1 more source

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