Results 121 to 130 of about 3,771 (207)

A multicomponent microemulsion using rational combination strategy improves lung cancer treatment through synergistic effects and deep tumor penetration

Drug Delivery, 2017
Previously, we have developed a multicomponent-based microemulsion composed of etoposide, coix seed oil, and ginsenoside Rh2 (ECG-MEs). In this study, our goal was to validate the feasibility of ECG-MEs in lung cancer treatment and explore the mechanism ...
Ding Qu, Mengfei Guo, Yue Qin, Lixiang Wang, Bing Zong, Yunyan Chen, Yan Chen   +6 more
doaj   +1 more source

Remodeling the tumor immune microenvironment through hydrogel encapsulated G-Rh2 in situ vaccine and systemic immunotherapy

Materials Today Bio
Ginsenoside Rh2 (G-Rh2) is a vital bioactive compound in Traditional Chinese Medicine, celebrated for its strong pharmacological properties, particularly its potent antitumor effects.
Chunhua Li, Dan Lei, Yudong Huang, Yuanhao Jing, Wanru Wang, Lanqi Cen, Zijian Wei, Anni Chen, Xiaoyu Feng, Yushu Wang, Lixia Yu, Ying Chen, Rutian Li   +12 more
doaj   +1 more source

Ginsenoside Rh2 regulates cardiomyocyte autophagy-dependent apoptosis through the PI3K-Akt-mTOR signaling pathway to attenuate doxorubicin-induced cardiotoxicity

Applied Biological Chemistry
Doxorubicin (DOX)-induced cardiotoxicity has become a major concern and is considered a limitation for the use of DOX in oncology treatment. Ginsenoside Rh2 (Rh2) is a ginseng extract with anti-inflammatory, antioxidant and cell cycle regulating ...
Youping Wu, Sheng Zhang, Liqiang Gu, Cong Xu, Xiaobo Lin, Hu Wang   +5 more
doaj   +1 more source

Tailored biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme [PDF]

, 2017
With the development of synthetic biology, substantial progress has been made in the low-cost production of plant natural products in microbes. Ginsenoside Rh2 is a potential anticancer drug isolated from medicinal plant ginseng.
Feng, Yan, Yangg, Guangyu, Zhang, Xueli, Zhuang, Yu   +3 more
core   +1 more source

Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3‐O‐UGT2

Advanced Science
Ginsenosides are a group of tetracyclic triterpenoids with promising health benefits, consisting of ginseng aglycone attached to various glycans. Pq3‐O‐UGT2, an important UDP‐dependent glycosyltransferase (UGT), catalyzes the production of Ginsenoside ...
Qiushuang Ji, Yirong Liu, Huanyu Zhang, Yan Gao, Yixin Ding, Yuanyuan Ding, Jing Xie, Jianyu Zhang, Xinghua Jin, Bin Lai, Cheng Chen, Juan Wang, Wenyuan Gao, Kunrong Mei   +13 more
doaj   +1 more source

The potential mechanism of Aidi injection against neuroblastoma—an investigation based on network pharmacology analysis

Frontiers in Pharmacology
Background: Aidi injection, a classic traditional Chinese medicine (TCM) formula, has been used on a broader scale in treating a variety of cancers. In this study, we aimed to explore the potential anti-tumor effects of Aidi injection in the treatment of
Shuyang Dai, Yaoyao Gu, Yong Zhan, Jie Zhang, Lulu Xie, Yi Li, Yifei Lu, Ran Yang, Enqing Zhou, Deqian Chen, Songbin Liu, Shan Zheng, Zhaopeng Shi, Kuiran Dong, Rui Dong   +14 more
doaj   +1 more source

Establishment of adventitious root co-culture of Ginseng and Echinacea for the production of secondary metabolites [PDF]

, 2008

core   +1 more source

Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria [PDF]

, 2013

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INDUCED DIFFERENTIATION OF HEPATOCELLULAR CARCINOMA BY NATURAL PRODUCTS [PDF]

, 2008
Hepatocellular carcinoma is one of the most common malignant tumors worldwide. For the difficulty of the giving sufficient dose because of the poor liver function and the low sensitivity of hepatoma cells for the chemotherapeutic agents, chemotherapy ...
Wu, Xiong-Zhi, Xie, Guang-Ru
core   +1 more source

A novel autophagy activator ginsenoside Rh2 enhances the efficacy of immunogenic chemotherapy. [PDF]

Clin Transl Med, 2023
Yang J, Zhang W, Jia L, Shi F, Cao M, Sun J, Xu C, Li Z, Cheng Z, Zhao SC, Wang J, Yang C.   +11 more
europepmc   +1 more source