Results 151 to 160 of about 3,001 (186)

Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats [PDF]

International Journal of Molecular Sciences, 2017
Ginsenoside Rh2 (Rh2) is an active principal ingredient contained in ginseng (Panax ginseng Meyer), a medicinal herb used to enhance health worldwide. The present study is designed to investigate the effect of Rh2 on myocardial fibrosis in diabetic rats.
Chao-Tien Hsu, Zhih-Cherng Chen, Chen Zhih-Cherng   +2 more
exaly   +2 more sources

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Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806

World Journal of Microbiology and Biotechnology, 2011
In the present investigation, we successfully employed a cell-free extract of Esteya vermicola CNU 120806 to convert ginsenoside Rg3 to Rh2. Three important factors including pH, temperature and substrate concentration were optimized for the preparation of Rh(2). The optimal condition was obtained as follows: 50°C, pH 5.0 and substrate concentration of
Jingang, Hou, Jianjie, Xue, Chunyan, Wang, Lei, Liu, Dongliang, Zhang, Zhen, Wang, Wei, Li, Yinan, Zheng, Changkeun, Sung   +8 more
openaire   +2 more sources

Synthesis and anti-cancer cell activity of pseudo-ginsenoside Rh2

Steroids, 2014
β-d-Glucopyranoside,(3β,12β,20E)-12,25-dihydroxydammar-20(22)-en-3-yl (pseudo-ginsenoside Rh2) and its 20Z-isomer were synthesized from ginsenoside Rh2 under a mild condition, via a simple three-step called acetylation, elimination-addition and saponification.
Guangtao, Qian, Zhicai, Wang, Jinyu, Zhao, Dandan, Li, Wei, Gao, Baohui, Wang, Dayuan, Sui, Xiangru, Qu, Yanping, Chen   +8 more
openaire   +2 more sources

[Effects of 20 (S) -ginsenoside Rh2 and 20 (R) -ginsenoside Rh2 on proliferation and apoptosis of human lung adenocarcinoma A549 cells].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011
To evaluate and explore the effects of 20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2 on the cytotoxicity, proliferation and the apoptosis of human lung adenocarcinoma A549 cells, and to illustrate the structure-activity relationship and possible mechanisms of anti-tumor active ingredients of ginseng.A549 cells were treated with different ...
Chunjing, Zhang, Haitao, Yu, Jincai, Hou
openaire   +3 more sources

Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts

Metabolic Engineering, 2015
Ginsenosides Rh2 and Rg3 represent promising candidates for cancer prevention and therapy and have low toxicity. However, the concentrations of Rh2 and Rg3 are extremely low in the bioactive constituents (triterpene saponins) of ginseng. Despite the available heterologous biosynthesis of their aglycone (protopanaxadiol, PPD) in yeast, production of Rh2
Pingping, Wang, Yongjun, Wei, Yun, Fan, Qunfang, Liu, Wei, Wei, Chengshuai, Yang, Lei, Zhang, Guoping, Zhao, Jianmin, Yue, Xing, Yan, Zhihua, Zhou   +10 more
openaire   +2 more sources

Generation of ginsenosides Rg3 and Rh2 from North American ginseng

Phytochemistry, 2004
Rg3 and Rh2 ginsenosides are primarily found in Korean red ginseng root (Panax ginseng C.A. Meyer) and valued for their bioactive properties. We quantified both Rh2 and Rg3 ginseng leaf and Rg3 from root extracts derived from North American ginseng (Panax quinquefolius).
David G, Popovich, David D, Kitts
openaire   +2 more sources

Research Progress on the Antitumor Molecular Mechanism of Ginsenoside Rh2

The American Journal of Chinese Medicine
Cancer has evolved into a substantial public health concern as the second-leading cause of mortality globally. Radiotherapy and chemotherapy have been the two most widely used cancer therapies in recent years; however, both have drawbacks. Therefore, the focus has shifted to the creation of herbal medicines, the extraction of active ingredients ...
Lan Yang, Jenny Jie Chen, Brian Sheng-Xian Teo, Jiong Zhang, Mingqiang Jiang   +4 more
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Ginsenoside Rh2 Inhibits Angiogenesis in Prostate Cancer by Targeting CNNM1

Journal of Nanoscience and Nanotechnology, 2019
To explore the molecular mechanism by which ginsenoside Rh2 (G-Rh2) inhibits prostate cancer by regulating vascular growth. Different concentrations of G-Rh2 with three prostate cancer cell lines (LNCaP, PC3 and DU145) were transplanted in nude mice, and tumor mass volume was measured over time.
Yaqiang, Huang, Hongxing, Huang, Zhaodong, Han, Wei, Li, Zhipeng, Mai, Runqiang, Yuan   +5 more
openaire   +2 more sources

Pharmacokinetics of Ginsenoside Rh2, the Major Anticancer Ingredient of Ginsenoside H Dripping Pills, in Healthy Subjects

Clinical Pharmacology in Drug Development, 2020
AbstractGinsenoside H dripping pill (GH) is a novel clinical‐stage adjuvant for the treatment of non‐small cell lung cancer. In this study, the pharmacokinetics of ginsenoside Rh2, the major anticancer ingredient of GH, was investigated in healthy volunteers.
Zhenlei, Wang, Rui, Liu, Li, Chen, Huanhuan, Wang, Mi, Zhou, Yongsheng, Wang, Yongping, Qin   +6 more
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Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells

Archives of Pharmacal Research, 2004
Ginseng has an anti-cancer effect in several cancer models. This study was to characterize active constituents of ginseng and their effects on proliferation of prostate cancer cell lines, LNCaP and PC3. Cell proliferation was measured by [3H]thymidine incorporation, the intracellular calcium concentration by a dual-wavelength spectrophotometer system ...
Hyun-Sook, Kim, Eun-Hee, Lee, Sung-Ryong, Ko, Kang-Ju, Choi, Jong-Hee, Park, Dong-Soon, Im   +5 more
openaire   +2 more sources