Molecular Mechanisms of Large-Conductance Ca 2+ [PDF]
Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013 Gintonin is a unique lysophosphatidic acid (LPA) receptor ligand found in Panax ginseng. Gintonin induces transient [Ca2+]i through G protein-coupled LPA receptors. Large-conductance Ca2+-activated K+ (BKCa) channels are expressed in blood vessels and
B. H. Lee +7 more
core +7 more sources
Ginseng Gintonin Contains Ligands for GPR40 and GPR55 [PDF]
Molecules, 2020 Gintonin, a novel ginseng-derived glycolipoprotein complex, has an exogenous ligand for lysophosphatidic acid (LPA) receptors. However, recent lipid analysis of gintonin has shown that gintonin also contains other bioactive lipids besides LPAs, including
Yeon-Jin Cho +9 more
doaj +5 more sources
Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration
Journal of Ginseng Research, 2016 Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest.
Sungmin Kim +7 more
doaj +4 more sources
Amelioration of muscle wasting by gintonin in cancer cachexia
Neoplasia: An International Journal for Oncology Research, 2021 Cancer cachexia is characterized by systemic inflammation, protein degradation, and loss of skeletal muscle. Despite extensive efforts to develop therapeutics, only few effective treatments are available to protect against cancer cachexia. Here, we found
Yoseph Toni Wijaya +4 more
doaj +4 more sources
Effects of gintonin-enriched fraction on hippocampal gene expressions
Integrative Medicine Research, 2021 Background: Recently, gintonin and gintonin-enriched fraction (GEF) have been isolated from ginseng, a herbal medicine. Gintonin induces [Ca2+]i transition in cultured hippocampal neurons and stimulates acetylcholine release through LPA receptor ...
Rami Lee +8 more
doaj +4 more sources
Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
Journal of Ginseng Research, 2021 Background: Gintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces in vitro morphological changes and migration through neuronal LPA1 receptor.
Do-Geun Kim +8 more
doaj +4 more sources
Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial [PDF]
Integrative Medicine Research, 2022 Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory ...
Woo-Jin Lee +7 more
doaj +3 more sources
Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders [PDF]
Cells, 2020 Neurodegenerative disorders, namely Parkinson’s disease (PD), Huntington’s disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS), are increasingly major health concerns due to the increasingly aged population worldwide.
Muhammad Ikram +3 more
doaj +5 more sources
Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release [PDF]
Molecules, 2021 Ginseng-derived gintonin reportedly contains functional lysophosphatidic acids (LPAs) as LPA receptor ligands. The effect of the gintonin-enriched fraction (GEF) on in vitro and in vivo glucagon-like protein-1 (GLP-1) secretion, which is known to ...
Rami Lee +7 more
doaj +5 more sources
Gintonin stimulates autophagic flux in primary cortical astrocytes
Journal of Ginseng Research, 2020 Background: Gintonin (GT), a novel ginseng-derived exogenous ligand of lysophosphatidic acid (LPA) receptors, has been shown to induce cell proliferation and migration in the hippocampus, regulate calcium-dependent ion channels in the astrocytes, and ...
Md. Ataur Rahman +3 more
doaj +4 more sources