Results 11 to 20 of about 631 (158)
Molecular Mechanisms of Large-Conductance Ca 2+ [PDF]
Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013 Gintonin is a unique lysophosphatidic acid (LPA) receptor ligand found in Panax ginseng. Gintonin induces transient [Ca2+]i through G protein-coupled LPA receptors. Large-conductance Ca2+-activated K+ (BKCa) channels are expressed in blood vessels and
B. H. Lee +7 more
core +5 more sources
Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release [PDF]
Molecules, 2021 Ginseng-derived gintonin reportedly contains functional lysophosphatidic acids (LPAs) as LPA receptor ligands. The effect of the gintonin-enriched fraction (GEF) on in vitro and in vivo glucagon-like protein-1 (GLP-1) secretion, which is known to ...
Rami Lee +7 more
doaj +5 more sources
Ginseng Gintonin Contains Ligands for GPR40 and GPR55 [PDF]
Molecules, 2020 Gintonin, a novel ginseng-derived glycolipoprotein complex, has an exogenous ligand for lysophosphatidic acid (LPA) receptors. However, recent lipid analysis of gintonin has shown that gintonin also contains other bioactive lipids besides LPAs, including
Yeon-Jin Cho +9 more
doaj +3 more sources
Gintonin absorption in intestinal model systems
Journal of Ginseng Research, 2018 Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing ...
Byung-Hwan Lee +7 more
doaj +3 more sources
Ginseng gintonin, aging societies, and geriatric brain diseases
Integrative Medicine Research, 2021 Background: A dramatic increase in aging populations and low birth rates rapidly drive aging societies and increase aging-associated neurodegenerative diseases.
Sun-Hye Choi +8 more
doaj +3 more sources
A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders [PDF]
Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016 Ginseng, a perennial plant belonging to the Panax genus of the Araliaceae family, has been used in China, Korea, and Japan as a traditional herbal medicine for thousands of years.
Akihiro Asakawa +9 more
core +6 more sources
Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
Journal of Ginseng Research, 2021 Background: Gintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces in vitro morphological changes and migration through neuronal LPA1 receptor.
Do-Geun Kim +8 more
doaj +3 more sources
Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation [PDF]
Biomolecules, 2020 Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, improves brain functions and protects neurons from oxidative stress. However, little is known about the effects of gintonin against Pb-induced brain maldevelopment.
Sung Min Nam +7 more
doaj +3 more sources
Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration
Journal of Ginseng Research, 2016 Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest.
Sungmin Kim +7 more
doaj +3 more sources
Neurolipid systems: A new target for the treatment of dementia [PDF]
Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 3, Page 225-236, September 2024.Neurolipids comprise a diverse class of bioactive lipids that include molecules capable of activating G protein-coupled receptors, thereby inducing systemic effects that contribute to the maintenance of homeostasis.
Bengoetxea de Tena, Iker +6 more
core +2 more sources