Results 31 to 40 of about 739 (165)
Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin [PDF]
Acta Pharmacologica Sinica, 2013 Ginseng, the root of Panax ginseng, has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects. Pharmacologic studies in the last decades have shown that ginsenosides (ginseng saponins) are primarily responsible for the actions of ginseng.
Im, Dong-soon, Nah, Seung-yeol
openaire +3 more sources
Gintonin enhances epithelial barrier function by activating NRF2 pathway in radiation-induced intestinal injury. [PDF]
J Ginseng ResBACKGROUND: Because the intestine is a radio-sensitive organ in the body, and radiation-induced intestinal injury is a major clinical problem associated with radiotherapy or radiological accidents. Dysfunction of the epithelial barrier leads to bacterial translocation to other organs, resulting in severe inflammation.
Jang H +6 more
europepmc +3 more sources
A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders [PDF]
Evidence-Based Complementary and Alternative Medicine, Volume 2016, Issue 1, 2016., 2016 Ginseng, a perennial plant belonging to the Panax genus of the Araliaceae family, has been used in China, Korea, and Japan as a traditional herbal medicine for thousands of years.
Akihiro Asakawa +9 more
core +6 more sources
Journal of Ginseng Research, 2021 Background: We recently showed that gintonin, an active ginseng ingredient, exhibits antibrain neurodegenerative disease effects including multiple target mechanisms such as antioxidative stress and antiinflammation via the lysophosphatidic acid (LPA ...
Sung Min Nam +9 more
doaj +2 more sources
Multi-Target Protective Effects of Gintonin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Mediated Model of Parkinson’s Disease via Lysophosphatidic Acid Receptors [PDF]
Frontiers in Pharmacology, 2018 Gintonin is a ginseng-derived lysophosphatidic acid receptor (LPAR) ligand. Although previous in vitro and in vivo studies demonstrated the therapeutic role of gintonin against Alzheimer’s disease, the neuroprotective effects of gintonin in Parkinson’s ...
Jong Hee Choi +7 more
doaj +2 more sources
Journal of Ginseng Research, 2019 Background: Gintonin is a ginseng-derived exogenous ligand of the G protein-coupled lysophosphatidic acid (LPA) receptor. We previously reported that gintonin stimulates gliotransmitter release in primary cortical astrocytes. Astrocytes play key roles in
Sun-Hye Choi +9 more
doaj +2 more sources
Neurolipid systems: A new target for the treatment of dementia [PDF]
Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 3, Page 225-236, September 2024.Neurolipids comprise a diverse class of bioactive lipids that include molecules capable of activating G protein-coupled receptors, thereby inducing systemic effects that contribute to the maintenance of homeostasis.
Bengoetxea de Tena, Iker +6 more
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Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects. [PDF]
Oxid Med Cell Longev, 2021 The study was aimed at analyzing the protective effects of gintonin in an amyloid beta‐ (Aβ‐) induced Alzheimer’s disease (AD) mouse model. For the development of the Aβ‐induced AD mouse model, the amyloid‐β (Aβ1-42) peptide was stereotaxically injected into the brains of mice. Subsequently, gintonin was administered at a dose of 100 mg/kg/day/per oral
Ikram M +6 more
europepmc +3 more sources
Bioactive lipids in gintonin-enriched fraction from ginseng
Journal of Ginseng Research, 2019 Background: Ginseng is a traditional herbal medicine for human health. Ginseng contains a bioactive ligand named gintonin. The active ingredient of gintonin is lysophosphatidic acid C18:2 (LPA C18:2).
Hee-Jung Cho +7 more
doaj +3 more sources
Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination [PDF]
International Journal of Environmental Research and Public Health, 2020 Gintonin is a newly discovered ingredient of ginseng and plays an exogenous ligand for G protein-coupled lysophosphatidic acid receptors. We previously showed that gintonin exhibits diverse effects from neurotransmitter release to improvement of Alzheimer’s disease-related cognitive dysfunctions.
Hyeon-Joong Kim +7 more
openaire +4 more sources