Ginseng Nanosizing: The Second Spring of Ginseng Therapeutic Applications [PDF]
AntioxidantsPlant-derived vesicles offer several advantages, including high yield, low cost, ethical compatibility, safety, and potential health benefits. These advantages enable them to overcome technological limitations associated with vesicles of mammalian origin.
Jian Wang +8 more
doaj +2 more sources
Gintonin-Enriched Fraction Suppresses Heat Stress-Induced Inflammation through LPA Receptor [PDF]
Molecules, 2020 Heat stress can be caused by various environmental factors. When exposed to heat stress, oxidative stress and inflammatory reaction occur due to an increase of reactive oxygen species (ROS) in the body.
Sungwoo Chei +7 more
doaj +3 more sources
A brief method for preparation of gintonin-enriched fraction from ginseng
Journal of Ginseng Research, 2015 Background: Ginseng has been used as a tonic for invigoration of the human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin.
Sun-Hye Choi +10 more
doaj +3 more sources
The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases [PDF]
Frontiers in Aging, 2023 The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages.
Samar F. Darwish +5 more
doaj +3 more sources
Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions [PDF]
Frontiers in Pharmacology, 2015 Ginseng, the root of Panax ginseng, is used as a traditional medicine. Despite the long history of the use of ginseng, there is no specific scientific or clinical rationale for ginseng pharmacology besides its application as a general tonic.
Seung-Yeol eNah +6 more
doaj +3 more sources
Journal of Ginseng Research, 2023 Background: Gintonin (GT), a Panax ginseng-derived lysophosphatidic acid receptor (LPAR) ligand, has positive effects in cultured or animal models for Parkinson's disease, Huntington's disease, and so on. However, the potential therapeutic value of GT in
Jong Hee Choi +4 more
doaj +2 more sources
Gintonin-Enriched Panax ginseng Extract Fraction Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis through DR4/5 Upregulation [PDF]
Current Issues in Molecular BiologyTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising chemotherapeutic agent because of its selective apoptotic action on cancer cells. However, resistance to TRAIL-induced apoptosis remains a challenge in many cancers.
Seongwoo Hong +7 more
doaj +2 more sources
Antimelanoma potential of natural compounds derived from plants: a systematic review of in vivo studies of B16 melanoma and its sublines. [PDF]
Braz J Med Biol ResCutaneous melanoma, a lethal neoplasm originating from epidermal melanocytes, stands out for its resistance to conventional therapies and high metastatic rate.
Gomes BS, Sousa JFM, Mendes RL.
europepmc +3 more sources
A Simple Method for the Preparation of Crude Gintonin from Ginseng Root, Stem, and Leaf [PDF]
Journal of Ginseng Research, 2011 Ginseng has been used as a general tonic agent to invigorate the human body as an adaptogenic agent. In a previous report, we have shown that ginseng contains a novel glycolipoprotein called gintonin. The main function of gintonin is to transiently enhance intracellular free Ca(2+) [Ca(2+)]i levels in animal cells.
Pyo, Mi Kyung +8 more
openaire +4 more sources
Journal of Ginseng Research, 2016 Background: Ginseng extracts are known to have angiogenic effects. However, to date, only limited information is available on the molecular mechanism underlying the angiogenic effects and the main components of ginseng that exert these effects.
Sung-Hee Hwang +8 more
doaj +2 more sources