Results 41 to 50 of about 631 (158)

Corrigendum to “Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2”[J Ginseng Res 45(5) September 2021, 575-582] [PDF]

Journal of Ginseng Research, 2023
Mijin Kim, Bongjun Sur, Thea Villa, Jaesuk Yun, Seung Yeol Nah, Seikwan Oh   +5 more
doaj   +2 more sources

Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient. [PDF]

Nutrients, 2023
Ginseng is one of the traditional herbal medicines for tonic. Gintonin is a new material derived from white/red ginseng and its lysophosphatidic acids (LPAs) play as a ligand for G protein-coupled LPA receptors. Korean red ginseng marc (KRGM) is a by-product after the KRG processes.
Lee R, Kim JH, Hwang H, Rhim H, Hwang SH, Cho IH, Cho IH, Kim DG, Kim HC, Nah SY.   +9 more
europepmc   +3 more sources

Biological evidence of gintonin efficacy in memory disorders

Pharmacological Research, 2021
Gintonin is a novel glycolipoprotein, which has been abundantly found in the root of Korean ginseng. It holds lysophosphatidic acids (LPAs), primarily identified LPA C18:2, and is an exogenous agonist of LPA receptors (LPARs). Gintonin maintains blood-brain barrier integrity, and it has recently been studied in several models of neurodegenerative ...
Md. Jakaria, Shofiul Azam, Eun-Ae Go, Md. Sahab Uddin, Song-Hee Jo, Dong-Kug Choi   +5 more
openaire   +2 more sources

An Edible Gintonin Preparation from Ginseng [PDF]

Journal of Ginseng Research, 2011
Ginseng, the root of Panax ginseng, is one of the oldest herbal medicines. It has a variety of physiological and pharmacological effects. Recently, we isolated a subset of glycolipoproteins that we designated gintonin, and demonstrated that it induced transient change in intracellular calcium concentration ([Ca(2+)]i) in cells via G-protein-coupled ...
Choi, Sun-Hye, Shin, Tae-Joon, Lee, Byung-Hwan, Hwang, Sung Hee, Kang, Jiyeon, Kim, Hyun-Joong, Park, Chan-Woo, Nah, Seung-Yeol   +7 more
openaire   +2 more sources

Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors

Journal of Ginseng Research, 2021
Background: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors.
Sun-Hye Choi, Na-Eun Lee, Hee-Jung Cho, Ra Mi Lee, Hyewhon Rhim, Hyoung-Chun Kim, Mun Han, Eun-Hee Lee, Juyoung Park, Seung-Yeol Nah   +9 more
doaj   +1 more source

Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects.

Oxid Med Cell Longev, 2021
The study was aimed at analyzing the protective effects of gintonin in an amyloid beta‐ (Aβ‐) induced Alzheimer’s disease (AD) mouse model. For the development of the Aβ‐induced AD mouse model, the amyloid‐β (Aβ1-42) peptide was stereotaxically injected into the brains of mice. Subsequently, gintonin was administered at a dose of 100 mg/kg/day/per oral
Ikram M, Jo MG, Park TJ, Kim MW, Khan I, Jo MH, Kim MO.   +6 more
europepmc   +2 more sources

Triculture Model of In Vitro BBB and its Application to Study BBB‐Associated Chemosensitivity and Drug Delivery in Glioblastoma

Advanced Functional Materials, Volume 32, Issue 10, March 2, 2022., 2022
The complicated glioblastoma multiforme (GBM) microenvironment and the anatomical features and functionality of the in vivo blood–brain barrier are replicated, and the influence of the GBM microenvironment on tumor behavior and drug delivery are demonstrated. Abstract Physiologically, brain tumors interact with surrounding vascular and glial cells, and
Suyeong Seo, Seung‐Yeol Nah, Kangwon Lee, Nakwon Choi, Hong Nam Kim   +4 more
wiley   +1 more source

Evaluation of Blood‐Brain‐Barrier Permeability, Neurotoxicity, and Potential Cognitive Impairment by Pseudomonas aeruginosa’s Virulence Factor Pyocyanin

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Pyocyanin (PCN) is a redox‐active secondary metabolite produced by Pseudomonas aeruginosa as its primary virulence factor. Several studies have reported the cytotoxic potential of PCN and its role during infection establishment and progression. Considering its ability to diffuse through biological membranes, it is hypothesized that PCN can gain entry ...
Muhammad Ibrahim Rashid, Habiba Rashid, Saadia Andleeb, Amjad Ali, Pablo Muriel   +4 more
wiley   +1 more source

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay [PDF]

, 2015
BACKGROUND: Currently there are no effective treatments for many neurodegenerative diseases. Reliable biomarkers for identifying and stratifying these diseases will be important in the development of future novel therapies.
Bahtia, K, Bliss, E, Carecchio, M, Fenoglio, C, Fox, NC, Galimberti, D, Hardy, J, Heales, S, Heslegrave, A, Heywood, WE, Magdalinou, NK, Mills, K, Paterson, RW, Reid, E, Scarpini, E, Schott, JM, Sebire, NJ, Sirka, E, Zetterburg, H   +18 more
core   +4 more sources

Gintonin stimulates gliotransmitter release in cortical primary astrocytes

Neuroscience Letters, 2015
Lysophosphatidic acid (LPA) is a simple and minor phospholipid, but serves as a lipid-derived neurotransmitter via activation of G protein-coupled LPA receptors. Astrocytes abundantly express LPA receptors and contain gliotransmitters that modulate astrocyte-neuron interactions. Gintonin is a novel ginseng-derived G protein-coupled LPA receptor ligand.
Hyunsook, Kim, Byung-Hwan, Lee, Sun-Hye, Choi, Hyeon-Joong, Kim, Suk-Won, Jung, Sung-Hee, Hwang, Hyewon, Rhim, Hyung-Chun, Kim, Ik-Hyun, Cho, Seung-Yeol, Nah   +9 more
  +10 more sources