Results 1 to 10 of about 9,944 (165)

Membrane-associated estrogen receptor α prevents the amyloid β-induced suppression of GIRK channel activity in hippocampal neurons from female mice [PDF]

Biology of Sex Differences
Background Amyloid β oligomers (oAβ) are a key pathogenic driver in Alzheimer’s Disease (AD). Neuronal G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels are important regulators of neuronal excitability and prominent somatodendritic effectors ...
Haichang Luo, Ezequiel Marron Fernandez de Velasco, Jaeyoon Kim, Praseuth Yang, Paul Mermelstein, Joseph V. Bonventre, Paul S. Cooke, Kevin Wickman   +7 more
doaj   +3 more sources

Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels [PDF]

Frontiers in Physiology
Ion channels play a pivotal role in regulating cellular excitability and signal transduction processes. Among the various ion channels, G-protein-coupled inwardly rectifying potassium (GIRK) channels serve as key mediators of neurotransmission and ...
Ha Nguyen, Ian W. Glaaser, Paul A. Slesinger   +2 more
doaj   +3 more sources

Comparing CB1 receptor GIRK channel responses to receptor internalization using a kinetic imaging assay [PDF]

Scientific Reports
The type 1 cannabinoid receptor (CB1R) mediates neurotransmitter release and synaptic plasticity in the central nervous system. Endogenous, plant-derived, synthetic cannabinoids bind to CB1R, initiating the inhibitory G-protein (Gi) and the β-arrestin ...
Haley K. Andersen, Duncan G. Vardakas, Julie A. Lamothe, Tannis E. A. Perault, Kenneth B. Walsh, Robert B. Laprairie   +5 more
doaj   +3 more sources

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels [PDF]

Nature Communications
Gi/o protein-coupled receptors (GPCRs) inhibit cardiac and neuronal excitability via G protein-activated K+ channels (GIRK), assembled by combinations of GIRK1 - GIRK4 subunits.
Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Theres Friesacher, Galit Tabak, Vladimir Tsemakhovich, Haritha P. Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zuhlke, Carmen W. Dessauer, Enno Klussmann, Yoni Haitin, Joel A. Hirsch, Anna Stary-Weinzinger, Daniel Yakubovich, Nathan Dascal   +18 more
doaj   +3 more sources

Heavy adolescent drinking makes the adult brain more vulnerable to ethanol by permanently altering the age-dependent interplay between alcohol, GIRK channels and activin. [PDF]

Mol Psychiatry
Adolescent binge drinking is a risk behavior associated with the development of neuropsychiatric disorders later in life, but the pathophysiological mechanisms rendering the adolescent brain vulnerable to the long-term consequences of heavy alcohol ...
Stürzenberger S, Bülow N, Kalinichenko LS, Licha R, Eulenburg V, Dahlmanns M, Müller CP, Zheng F, Alzheimer C.   +8 more
europepmc   +2 more sources

GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders

Biomedicines, 2022
Substance use disorders (SUDs) are chronic, lifelong disorders that have serious consequences. Repeated substance use alters brain function. G-protein-activated inwardly rectifying potassium (GIRK) channels are expressed widely in the brain, including ...
Hiroko Kotajima-Murakami, Soichiro Ide, Kazutaka Ikeda   +2 more
doaj   +2 more sources

Increased GIRK channel activity prevents arrhythmia in mice with heart failure by enhancing ventricular repolarization

Scientific Reports, 2023
Ventricular arrhythmia causing sudden cardiac death is the leading mode of death in patients with heart failure. Yet, the mechanisms that prevent ventricular arrhythmias in heart failure are not well characterized.
Xue An, Hana Cho
doaj   +2 more sources

Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor

Frontiers in Cellular Neuroscience, 2023
De novo mutations in GNB1, encoding the Gβ1 subunit of G proteins, cause a neurodevelopmental disorder with global developmental delay and epilepsy, GNB1 encephalopathy.
Sophie Colombo, Haritha P. Reddy, Haritha P. Reddy, Sabrina Petri, Damian J. Williams, Boris Shalomov, Ryan S. Dhindsa, Sahar Gelfman, Daniel Krizay, Amal K. Bera, Mu Yang, Mu Yang, Yueqing Peng, Yueqing Peng, Christopher D. Makinson, Christopher D. Makinson, Christopher D. Makinson, Michael J. Boland, Michael J. Boland, Wayne N. Frankel, Wayne N. Frankel, David B. Goldstein, David B. Goldstein, Nathan Dascal   +23 more
doaj   +2 more sources

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels

eLife, 2020
G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP2. Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP2 concentration.
Yiming Niu, Xiao Tao, Kouki K Touhara, Roderick MacKinnon   +3 more
doaj   +2 more sources

Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice. [PDF]

Sci Signal
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by amyloid plaques and cognitive decline, the latter of which is thought to be driven by soluble oligomeric amyloid-β (oAβ).
Luo H, Marron Fernandez de Velasco E, Gansemer B, Frederick M, Aguado C, Luján R, Thayer SA, Wickman K.   +7 more
europepmc   +2 more sources