Results 101 to 110 of about 10,013 (222)

Firing Modes of Dopamine Neurons Drive Bidirectional GIRK Channel Plasticity [PDF]

The Journal of Neuroscience, 2014
G-protein-coupled inwardly rectifying potassium (GIRK) channels contribute to the resting membrane potential of many neurons, including dopamine (DA) neurons in the ventral tegmental area (VTA). VTA DA neurons are bistable, firing in two modes: one characterized by bursts of action potentials, the other by tonic firing at a lower frequency.
Lalive d'Epinay, Arnaud, Munoz, Michaelanne B, Bellone, Camilla, Slesinger, Paul A, Luscher, Christian, Tan, Kelly   +5 more
openaire   +5 more sources

Upstream CB1R Regulation of β‐Adrenergic Memory Consolidation

Hippocampus, Volume 36, Issue 2, March 2026.
ABSTRACT Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β‐adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus.
Janine I. Rossato, Lucas Ribeiro, Thais Lima‐Silva, Raquel Araujo, Rodrigo Orvate, Anna Lyvia Azevedo, Nina Bevilaqua Cammarota, Ana Luizi Baracho, Livia Carneiro, Martín Cammarota   +9 more
wiley   +1 more source

Selective Effects of D- and L-Govadine in Preclinical Tests of Positive, Negative, and Cognitive Symptoms of Schizophrenia [PDF]

, 2014
There is a critical need to develop novel pharmacotherapeutics capable of addressing the positive, negative, and cognitive symptoms of schizophrenia.
Ahn, Kee-Chan, Ahn, Soyon, Ashby, Donovan M, Chambers, R Andrew, Lapish, Christopher C, Phillips, Anthony G   +5 more
core   +1 more source

Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior

Journal of Neuroscience, 2021
Systemic administration of ML297, a selective activator of G-protein-gated inwardly rectifying K+ (GIRK) channels, decreases innate avoidance behavior in male C57BL/6J mice.
Baovi N. Vo, Ezequiel Marron Fernandez de Velasco, T. Rose, Hannah M Oberle, Haichang Luo, C. Hopkins, K. Wickman   +6 more
semanticscholar   +1 more source

G Protein‐Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
ABSTRACT Stimulation of nociceptin/orphanin FQ peptide (NOP) opioid receptors by the endogenous ligand nociceptin (Noc) leads to voltage‐gated Ca2+ channel inhibition or G protein inwardly rectifying K+ channel activation. One mechanism of G protein‐coupled receptor (GPCR) desensitization occurs when G protein‐coupled receptor kinases (GRK ...
Mohamed Farrag, Marwa Soliman, Saifeldin Mahmoud, Lauren Miller, Paul B. Herold, Kristen Brandt, Victor Ruiz‐Velasco   +6 more
wiley   +1 more source

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors [PDF]

, 2019
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl ...
Bazovkina, Daria, Bijata, Monika, Galil, Dalia Abdel, Gorinski, Nataliya, Kondaurova, Elena, Kulikova, Elizabeth [u.v.m.], Prasad, Sonal, Sigrist, Stephan, Wirth, Alexander, Zeug, Andre   +9 more
core   +1 more source

ɑO‐Conotoxin GeXIVA isomers modulate N‐type calcium (CaV2.2) channels and inwardly‐rectifying potassium (GIRK) channels via GABAB receptor activation

Journal of Neurochemistry, 2021
αO‐Conotoxin GeXIVA is a 28 amino acid peptide derived from the venom of the marine snail Conus generalis. The presence of four cysteine residues in the structure of GeXIVA allows it to have three different disulfide isomers, that is, the globular ...
Arsalan Yousuf, Xiaosa Wu, Anuja R. Bony, Mahsa Sadeghi, Yen‐Hua Huang, D. Craik, David John Adams   +6 more
semanticscholar   +1 more source

GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin [PDF]

The Journal of Neuroscience, 2015
Melatonin supplementation has been used as a therapeutic agent for several diseases, yet little is known about the underlying mechanisms by which melatonin synchronizes circadian rhythms. G-protein signaling plays a large role in melatonin-induced phase shifts of locomotor behavior and melatonin receptors activate G-protein-coupled inwardly rectifying ...
Lauren M. Hablitz, Hylton E. Molzof, Kathryn E. Abrahamsson, Joanna M. Cooper, Rebecca A. Prosser, Karen L. Gamble   +5 more
openaire   +2 more sources

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti‐Related Peptide (NPY/AgRP) Neurons

Obesity, Volume 34, Issue 1, Page 175-187, January 2026.
ABSTRACT Objective Topiramate is a medication used off‐label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.
Moein Minbashi Moeini, Olivier Lavoie, Alexandre Caron, Kevin W. Williams, Natalie J. Michael   +4 more
wiley   +1 more source

Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by Gβγ subunits and function as heteromultimers [PDF]

, 1995
Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three isoforms of a G-protein-coupled, inwardly rectifying K+ channel (GIRK) have
Davidson, Norman, Kofuji, Paulo, Lester, Henry A.   +2 more
core