Chronic Fluoxetine Treatment Desensitizes Serotoninergic Inhibition of GABAergic Inputs and Intrinsic Excitability of Dorsal Raphe Serotonin Neurons [PDF]
Brain SciencesBackground: Dorsal raphe serotonin (5-hydroxytryptamine, 5-HT) neurons are spontaneously active and release 5-HT that is critical for normal brain function and regulates mood and emotion.
Wei Zhang, Ying Jin, Fu-Ming Zhou
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Molecular basis of signaling specificity between GIRK channels and GPCRs
eLife, 2018 Stimulated muscarinic acetylcholine receptors (M2Rs) release Gβγ subunits, which slow heart rate by activating a G protein-gated K+ channel (GIRK). Stimulated β2 adrenergic receptors (β2ARs) also release Gβγ subunits, but GIRK is not activated.
Kouki K Touhara, Roderick MacKinnon
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Frontiers in Behavioral Neuroscience, 2021 Pathological impairments in the regulation of affect (i.e., emotion) and flexible decision-making are commonly observed across numerous neuropsychiatric disorders and are thought to reflect dysfunction of cortical and subcortical circuits that arise in ...
Eden M. Anderson +4 more
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Mechanism of PKCε regulation of cardiac GIRK channel gating
Proceedings of the National Academy of Sciences, 2022 Significance Overactivity of a potassium ion channel (GIRK1/4) in the upper chambers of the heart has been thought to contribute to atrial fibrillation (AF), a widely prevalent heart rhythm abnormality or arrhythmia in the aging population and a ...
Kirin D Gada +5 more
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Ion fluxes through KCa2 (SK) and Cav1 (L-type) channels contribute to chronoselectivity of adenosine A1 receptor-mediated actions in spontaneously beating rat atria [PDF]
Frontiers in Pharmacology, 2016 Impulse generation in supraventricular tissue is inhibited by adenosine and acetylcholine via the activation of A1 and M2 receptors coupled to inwardly rectifying GIRK/KIR3.1/3.4 channels, respectively.
Paulo eCorreia-De-Sá
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Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics. [PDF]
Prog NeurobiolLuo H +6 more
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Advances in Targeting GIRK Channels in Disease.
Trends in Pharmacological Sciences, 2021 G protein-gated inwardly rectifying potassium (GIRK) channels are essential regulators of cell excitability in the brain. While they are implicated in a variety of neurological diseases in both human and animal model studies, their therapeutic potential has been largely untapped.
Yulin Zhao +3 more
semanticscholar +4 more sources
Neuron, 2002 G protein-activated potassium channels (GIRKs), monitored with the temporal and molecular resolution of electrophysiology, play a key role in the study of signal transduction. GIRKs are activated primarily by the G(beta)(gamma) subunits, but a paper by Peleg et al.
Kovoor, Abraham, Lester, Henry A.
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Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation. [PDF]
PLoS ONE, 2018 G protein-gated inwardly rectifying K+ (GIRK) channel regulates cellular excitability upon activation of Gi/o-coupled receptors. In Gi/o-coupled muscarinic M2R, the intracellular third loop (i3) is known as a key domain for Gi/o coupling, because ...
Michihiro Tateyama, Yoshihiro Kubo
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Identification of a G-Protein-Independent Activator of GIRK Channels
Cell Reports, 2020 Summary: G-protein-gated inwardly rectifying K+ (GIRK) channels are essential effectors of inhibitory neurotransmission in the brain. GIRK channels have been implicated in diseases with abnormal neuronal excitability, including epilepsy and addiction ...
Yulin Zhao +10 more
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