Results 31 to 40 of about 10,013 (222)
International Journal of Molecular Sciences, 2023 The midbrain raphe serotonin (5HT) neurons provide the main ascending serotonergic projection to the forebrain, including hippocampus, which has a role in the pathophysiology of depressive disorder.
P. Ambrogini +7 more
semanticscholar +1 more source
Impairments in hippocampal oscillations accompany the loss of LTP induced by GIRK activity blockade
Neuropharmacology, 2023 Learning and memory occurrence requires of hippocampal long-term synaptic plasticity and a precise neural activity orchestrated by brain network oscillations, both processes reciprocally influencing each other.
A. Contreras +7 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2023 Mutations in the KCNJ5 gene, encoding one of the major subunits of cardiac G-protein-gated inwardly rectifying K+ (GIRK) channels, have been recently linked to inherited forms of sinus node dysfunction.
Anne Kayser +5 more
semanticscholar +1 more source
Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Altered heart rate variability (HRV), arising from impaired chronotropic response of sinoatrial node (SAN) pacemaker activity to vagal input, has been proposed as an early diagnostic marker in sepsis.
Niroj Shrestha +17 more
semanticscholar +1 more source
Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. [PDF]
PLoS ONE, 2011 Various antidepressants are commonly used for the treatment of depression and several other neuropsychiatric disorders. In addition to their primary effects on serotonergic or noradrenergic neurotransmitter systems, antidepressants have been shown to ...
Toru Kobayashi +2 more
doaj +1 more source
Targeting GIRK Channels for the Development of New Therapeutic Agents
Frontiers in Pharmacology, 2011 G protein-coupled inward rectifier K+ (GIRK) channels represent novel targets for the development of new therapeutic agents. GIRK channels are activated by a large number of G protein-coupled receptors (GPCRs) and regulate the electrical activity of ...
Kenneth eWalsh
doaj +1 more source
Reduced GABA-B/GIRK-mediated regulation of the VTA following a single exposure to cocaine [PDF]
, 2012 In this paper, Arora and colleagues expand on their previous work on GIRK channels in the ventral tegmental area (VTA) presenting evidence that a single exposure to cocaine reduces inhibitory GABAergic transmission to dopamine (DA) neurons in the ventral
Andrew Varnell +2 more
core +2 more sources
Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels [PDF]
, 1998 Heteromultimeric G protein-activated inward rectifier K+ (GIRK) channels, abundant in heart and brain, help to determine the cellular membrane potential as well as the frequency and duration of electrical impulses. The sequence arginine-glycine-aspartate
Dang, Yan L. +3 more
core +1 more source
International Journal of Molecular Sciences, 2023 Pulmonary veins (PV) are the main source of ectopy, triggering atrial fibrillation. This study investigated the roles of G protein-coupled inwardly rectifying potassium (GIRK) channels in the PV and the left atrium (LA) of the rat.
Ian Findlay +4 more
semanticscholar +1 more source
PLoS ONE, 2015 G protein-activated inwardly rectifying potassium (GIRK) channels in 5-HT neurons are assumed to be principal effectors of 5-hydroxytryptamine 1A (5-HT1A) autoreceptors, but their pharmacology, subunit composition and the role in regulation of 5-HT ...
Alberto Montalbano +2 more
doaj +1 more source