Results 101 to 110 of about 2,770 (195)

Effect of glabridinon on insulin resistance, C-reactive protein and endothelial function in young women with polycystic ovary syndrome

Bangladesh Journal of Pharmacology, 2015
In the present study 32 women with polycystic ovary syndrome were treated with glabridin (10 µM) daily for 12 months. The results revealed a significant reduction in serum testosterone from 95.3 ± 23.6 to 49.8 ± 12.7 ng/dL and fasting insulin ...
Bing-Guo Luan, Cai-Xia Sun
doaj  

Glabridin as a Potential Therapeutic Agent for COPD: Mechanistic Insights into JAK1/STAT1 Pathway Inhibition

Pharmacognosy Magazine
Background Chronic obstructive pulmonary disease (COPD) is a common inflammatory disorder that is significantly aggravated by tobacco smoke exposure. Objectives This study aimed to explore the effect of glabridin (Glab) on the inflammatory response and ...
Wei-Wei Yuan, Hongtao Tan, Huihui Li, Junxian Chen, Jun Qiu   +4 more
semanticscholar   +1 more source

Glabridin Prevents Doxorubicin-Induced Cardiotoxicity Through Gut Microbiota Modulation and Colonic Macrophage Polarization in Mice

Frontiers in Pharmacology, 2019
The chemotherapeutic drug doxorubicin (DOX) provokes a dose-related cardiotoxicity. Thus, there is an urgent need to identify the underlying mechanisms and develop strategies to overcome them. Here we demonstrated that glabridin (GLA), an isoflavone from
Keqing Huang, Yanzhuo Liu, Yanzhuo Liu, Honglin Tang, Miao Qiu, Miao Qiu, Chenhong Li, Chenfan Duan, Chenlong Wang, Jing Yang, Xiaoyang Zhou   +10 more
doaj   +1 more source

Identification of pterocarpan reductases and prenyltransferases reveals bifurcated biosynthetic pathways for glabridin in Glycyrrhiza glabra

Industrial Crops and Products
Glabridin is a key chemical and biological marker of Glycyrrhiza glabra L., with significant market demand due to its anti-inflammatory, antioxidant and skin-brightening properties. Currently, glabridin is primarily extracted from the roots of G. glabra,
Yao Xu, Dan Jiang, Shijun Yuan, Lingfang Feng, Meng Xia, Ping Su, Muyao Yu, Yuyang Zhao, Yuxuan Wu, Yifeng Zhang, Chunsheng Liu   +10 more
doaj   +1 more source

Bioactive Candy: Effects of Licorice on the Cardiovascular System

Foods, 2019
Licorice, today chiefly utilized as a flavoring additive in tea, tobacco and candy, is one of the oldest used herbs for medicinal purposes and consists of up to 300 active compounds.
Mikkel R. Deutch, Daniela Grimm, Markus Wehland, Manfred Infanger, Marcus Krüger   +4 more
doaj   +1 more source

Development and optimization of the Glabridin-loaded dissolving microneedle for enhanced treatment of keloid

International Journal of Pharmaceutics: X
Glabridin (Gla) has been reported to have significant effects in scar treatment, and however, the water insolubility of Gla leads to its poor transdermal absorption ability, which affects its bioactivities.
Juan Guo, Zhong-Tang Chen, Rong Huang, Dan-Dan Tang, Yuh-Tai Wang, Pan Song, Liangyu Mei, Shuguang Hou, Wei Peng, Li-Shan He, Qiang Ren   +10 more
semanticscholar   +1 more source

Glabridin alleviates inflammation and nociception in rodents by activating BKCa channels and reducing NO levels

, 2020
Inflammation, and the pain that accompanies it, is a natural response of the body. The licorice plant (Glycyrrhiza glabra) have demonstrated anti-inflammatory, anti-edematous, and anti-nociceptive effects of its extracts. The effective ingredient remains
Arslan, SEYFULLAH OKTAY, Parlar, Ali, Çam, SALİHA AYŞENUR   +2 more
core   +1 more source

Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra

, 2007
Glabridin is a major constituent of the root of Glycyrrhiza glabra, which is commonly used in the treatment of cardiovascular and central nervous system diseases.
Al Xu (20014542), E Chen (10708762), J Liang (7713770), J Cao (6848969), W Duan (13462908), Xiao-Tian Li (4608457), Fwu Sheu (20012178), Xi-Yong Yu (293973), Shufeng Zhou (398572), X Chen (7409627), Jing-Yuan Wen (20012079), Xue-Qing Yu (11865637), Min Huang (161268)   +12 more
core  

GLABRIDIN FROM CHINESE HERB LICORICE INHIBITS FATIGUE IN MICE [PDF]

, 2009
The inhibiting effect of glabridin from Chinese herb Licorice on fatigue was investigated in male BALB/c mice. Mice were divided into the following 4 experimental groups: control group (CG), low dose group (LG), middle dose group (MG) and high dose group
Cao, H., Shang, H., Zheng, H., Putheti, R., Wang, J.   +4 more
core  

Regional environmental impacts on growth traits and phytochemical profiles of Glycyrrhiza glabra L. for enhanced medicinal and industrial use

BMC Plant Biology
Identifying the optimal cultivation regions and evaluating the impact of environmental factors are crucial for selecting the best conditions for the commercial production of important medicinal and industrial plants.
Ghasem Eghlima, Yasaman Mashhadi Tafreshi, Fateme Aghamir, Hamid Ahadi, Mehrnaz Hatami   +4 more
doaj   +1 more source