Results 21 to 30 of about 22,955 (239)

The cAMP Inducers Modify N-Acetylaspartate Metabolism in Wistar Rat Brain

open access: yesAntioxidants, 2021
Neuronal N-acetylaspartate production appears in the presence of aspartate N-acetyltransferase (NAT8L) and binds acetyl groups from acetyl-CoA with aspartic acid.
Robert Kowalski   +5 more
doaj   +1 more source

Co Expression of GMFβ, IL33, CCL2 and SDF1 Genes in the Acute Stage of Toxoplasmosis in Mice Model and Relation for Neuronal Impairment

open access: yesIranian Journal of Parasitology, 2021
Background: Toxoplasma gondii is an obligate intracellular parasite that migrates through macrophages or dendritic cells to neurons and nerve cells.
Mehri Najafi   +4 more
doaj   +1 more source

GDE6 promotes progenitor identity in the vertebrate neural tube

open access: yesFrontiers in Neuroscience, 2023
The generation of neurons in the central nervous system is a complex, stepwise process necessitating the coordinated activity of mitotic progenitors known as radial glia. Following neural tube closure, radial glia undergo a period of active proliferation
Madeline McKean   +8 more
doaj   +1 more source

MicroRNA-5195-3p alleviates high glucose‑induced injury in human ARPE-19 cells by targeting GMFB.

open access: yesPLoS ONE, 2021
Hyperglycemia is generally considered to be an important cause of diabetic retinopathy (DR). The aim of the present study was to investigate the role of miR-5195-3p in high glucose (HG)-induced human retinal pigment epithelial ARPE-19 cell injury.
Jingjing Liu   +4 more
doaj   +2 more sources

Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators. [PDF]

open access: yesPLoS ONE, 2015
Parkinson's disease (PD) is characterized by the presence of Lewy bodies and degeneration of dopaminergic neurons. 1-methyl-4-phenylpyridinium (MPP+), a metabolite of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Lewy body component ...
Duraisamy Kempuraj   +7 more
doaj   +1 more source

Glia maturation factor-γ mediates neutrophil chemotaxis [PDF]

open access: yesJournal of Leukocyte Biology, 2011
ABSTRACTChemotaxis is fundamental to the directional migration of neutrophils toward endogenous and exogenous chemoattractants. Recent studies have demonstrated that ADF/cofilin superfamily members play important roles in reorganizing the actin cytoskeleton by disassembling actin filaments.
Wulin, Aerbajinai   +5 more
openaire   +2 more sources

Protective Effects of Early Caffeine Administration in Hyperoxia-Induced Neurotoxicity in the Juvenile Rat

open access: yesAntioxidants, 2023
High-risk preterm infants are affected by a higher incidence of cognitive developmental deficits due to the unavoidable risk factor of oxygen toxicity. Caffeine is known to have a protective effect in preventing bronchopulmonary dysplasia associated with
Julia Heise   +3 more
doaj   +1 more source

Glia maturation factor gamma regulates the migration and adherence of human T lymphocytes

open access: yesBMC Immunology, 2012
Background Lymphocyte migration and chemotaxis are essential for effective immune surveillance. A critical aspect of migration is cell polarization and the extension of pseudopodia in the direction of movement.
Lippert Dustin ND, Wilkins John A
doaj   +1 more source

Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons. [PDF]

open access: yesPLoS ONE, 2017
The neurotrophic factor neuregulin 1 (NRG1) regulates neuronal development, glial differentiation, and excitatory synapse maturation. NRG1 is synthesized as a membrane-anchored precursor and is then liberated by proteolytic processing or exocytosis ...
Yuriko Iwakura   +6 more
doaj   +1 more source

Antiproliferative function of glia maturation factor beta. [PDF]

open access: yesCell Regulation, 1990
Recombinant human glia maturation factor beta (GMF-beta) reversibly inhibits the proliferation of neoplastic cells in culture by arresting the cells in the G0/G1 phase. This phenomenon is not target-cell specific, as neural and nonneural cells are equally inhibited.
R, Lim, W X, Zhong, A, Zaheer
openaire   +2 more sources

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