Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]
, 2017 A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro +4 more
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Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature [PDF]
, 2017 The concept that solid tumors are maintained by a productive interplay between neoplastic and non-neoplastic elements has gained traction with the demonstration that stromal fibroblasts and immune system cells dictate cancer development and progression ...
Bush, Erin C +6 more
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KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment [PDF]
, 2016 Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methylating agent ...
Catalano, Myriam +13 more
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Drug Design, Development and Therapy, 2022 Peizhang Wu,1,2 Jun Guo,2 Hongwei Yang,2 Debin Yuan,2 Chaoxiang Wang,2 Zhong Wang1 1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People’s Republic of China; 2Department of Neurosurgery, Yancheng First ...
Wu P +5 more
doaj
DUSP10 upregulation is a poor prognosticator and promotes cell proliferation and migration in glioma
Frontiers in Oncology, 2023 Dual-specificity phosphatase 10 (DUSP10) correlates with inflammation, cytokine secretion, cell proliferation, survival, and apoptosis. However, its role in glioma is unclear.
Fang Zhou +17 more
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Selective Targeting to Glioma with Nucleic Acid Aptamers [PDF]
, 2015 Malignant glioma is characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue; hence, diagnosis and treatment is difficult and patient survival is poor.
Alder, Jane Elizabeth +7 more
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Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner. [PDF]
, 2017 Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma.
Amantini, C +7 more
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MicroRNA-29a-3p Downregulation Causes Gab1 Upregulation to Promote Glioma Cell Proliferation
Cellular Physiology and Biochemistry, 2018 Background/Aims: Glioma causes significant human mortalities annually. Molecularly-targeted therapy is a focus of glioma research. Methods: Grb2-associated binding 1 (Gab1) expression and microRNA-29a-3p (“miR-29a-3p”) expression in human glioma cells ...
Nai-yuan Shao +7 more
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Mathematical model of brain tumour with glia-neuron interactions and chemotherapy treatment [PDF]
, 2015 Acknowledgements This study was possible by partial financial support from the following Brazilian government agencies: Fundação Araucária, EPSRC-EP/I032606/1 and CNPq, CAPES and Science Without Borders Program Process nos. 17656125, 99999.010583/2013-00
Baptista, Murilo Da Silva +7 more
core +1 more source
Drug Delivery, 2018 Development of safe, efficient nanocomplex for targeted imaging and therapy of cancer stem cells in brain glioma has become a great challenge. Herein, a low-density lipoprotein receptor-related protein and a RNA aptamer bound CD133 were used as dual ...
Xiyang Sun +7 more
doaj +1 more source