Results 141 to 150 of about 74,517 (259)

Acute splenomegaly, haemolysis, and thrombocytopenia following luspatercept initiation in a patient with transfusion‐dependent thalassaemia: A case report

open access: yesBritish Journal of Haematology, Volume 206, Issue 6, Page 1806-1810, June 2025.
Summary Patients with transfusion‐dependent thalassaemia (TDT) require chronic, life‐sustaining red blood cell transfusions, which contribute to iron overload and associated morbidity and mortality. Luspatercept, an inhibitor of the transforming growth factor‐beta pathway, decreases transfusion requirements in a subset of transfusion‐dependent β ...
Bianca Zaidel   +2 more
wiley   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

open access: yesNeuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata   +6 more
wiley   +1 more source

Rates of Reaction of Native Human Globin with Some Hemes

open access: hybrid, 1963
Quentin Gibson, Eraldo Antonini
openalex   +1 more source

Intrinsically Disordered Regions Define Unique Protein Interaction Networks in CHD Family Remodelers

open access: yesThe FASEB Journal, Volume 39, Issue 10, 31 May 2025.
The protein–protein interaction (PPI) networks were mapped for the intrinsically disordered N‐ and C‐termini of nine CHD family members. AlphaFold Multimer was used to predict interaction interfaces, with a focus on the interaction between the CHD4 C‐terminus and GATAD2B.
Mehdi Sharifi Tabar   +9 more
wiley   +1 more source

Konvergenter Aufbau Homo‐ und Heterotypischer Ubiquitinketten aus funktionaliserten, exprimierten Monomeren mittels Thiol‐En‐Chemie

open access: yesAngewandte Chemie, Volume 137, Issue 21, May 19, 2025.
Die Erzeugung funktionalisierter Ubiquitinbausteine mittels Expression in E. coli bietet Zugang zu verschiedenen Di‐, Tri‐ und Tetra‐Ubiquitinketten. Photoinitiierte Thiol‐En‐Klickreaktionen werden dabei in Kombination mit einer Maskierungs‐ und Schutzgruppenstrategie zum kontrollierten Aufbau von Ubiquitinketten sowie zur Semisynthese von ...
Moritz Urschbach   +6 more
wiley   +1 more source

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