Results 91 to 100 of about 11,873 (185)

Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia

BioEssays, Volume 47, Issue 6, June 2025.
Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
wiley   +1 more source

Impact of Voxelotor on Red Blood Cell Exchange Therapeutic Procedures: Evaluation of Multi‐Institutional Procedure Data

Journal of Clinical Apheresis, Volume 40, Issue 3, June 2025.
ABSTRACT Hemoglobin S (HbS) polymerization inhibitor drugs such as voxelotor can result in a split peak in HbS as well as additional peaks with hemoglobin A in quantitative methods of HbS measurement. It is unclear how these results should be used to make transfusion decisions.
Sally Campbell‐Lee, Ming Jin, Lisandro Fortuny, Daniel Sop, Suzanne Thibodeaux, Susan D‐Roseff   +5 more
wiley   +1 more source

Applying the National Genomic DNA Reference Materials to Evaluate the Performance of Nanopore Sequencing in Identifying Thalassemia Variants

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
This study mainly to evaluate the performance of nanopore technology in thalassemia detection by utilizing the national genomic reference materials in China. We proved that the reference materials can be used to evaluate the performance of nanopore sequencing in identifying thalassemia mutations, and it's necessary to incorporate triplicates when ...
Xingyu Wei, Xu Yang, Wanqing Han, Li Zhang, Guojun Ouyang, Shoufang Qu, Fang Yang, Xuexi Yang   +7 more
wiley   +1 more source

Optimisation of the Danish national haemoglobinopathy screening programme – A prospective intervention study

eJHaem, Volume 6, Issue 3, June 2025.
Abstract Introduction The Danish national haemoglobinopathy screening programme offers screening to at‐risk pregnant women. Despite efforts to increase awareness of the screening programme, most women in the target population remain unscreened. In contrast, > 90% of pregnant women in Denmark attend a screening for chromosomal abnormalities by combined ...
Esther Agnethe Ejskjær Gravholt, Finn Stener Jørgensen, Charlotte Holm, Jesper Petersen, Amina Nardo‐Marino, Mathis Mottelson, Andreas Glenthøj   +6 more
wiley   +1 more source

Comparison of Evolutionary Relationships between Branchiostoma floridae, Ciona intestinalis, and Homo sapiens Globins Provide Evidence of Gene Co-Option and Convergent Evolution. [PDF]

Int J Mol Sci, 2023
Yano N, Minamoto T, Yamaguchi H, Goto T, Nishikata T.   +4 more
europepmc   +1 more source

BdNRT2A and BdNRT3.2 Are the Major Components of the High‐Affinity Nitrate Transport System in Brachypodium distachyon

Plant Direct, Volume 9, Issue 6, June 2025.
ABSTRACT An efficient nitrate uptake system contributes to the improvement of crop nitrogen use efficiency under low nitrogen availability. The High Affinity nitrate Transport System (HATS) in plants is active in low range of external nitrate and is mediated by a two‐component system (high affinity transporters NRT2 associated to a partner protein NRT3
Laure C. David, Mathilde Grégoire, Patrick Berquin, Anne Marmagne, Marion Dalmais, Abdelhafid Bendahmane, Tony J. Miller, Anne Krapp, Françoise Daniel‐Vedele, Thomas Girin, Sylvie Ferrario‐Méry   +10 more
wiley   +1 more source

BacS: An Abundant Bacteroid Protein in \u3cem\u3eRhizobium etli\u3c/em\u3e Whose Expression Ex Planta Requires \u3cem\u3enifA\u3c/em\u3e [PDF]

, 2003
Rhizobium etli CFN42 bacteroids from bean nodules possessed an abundant 16-kDa protein (BacS) that was found in the membrane pellet after cell disruption. This protein was not detected in bacteria cultured in tryptone-yeast extract.
Davila, Guillermo, Jahn, Olivia Jeanne, Noel, K. Dale, Romero, David   +3 more
core   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia [PDF]

, 2017
The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O2 sensing via the HIF pathway.
Abele, D., Burmester, T., Fandrey, J., Gorr, T. A., Hankeln, T., Heise, K., Hoogewijs, D., Lucassen, M., Maxwell, P. H., Nikinmaa, M., Powell-Coffman, J. A., Påhlman, S., Rytkönen, K. T., Terwilliger, N. B., Tokishita, S., Webster, K. A., Yamagata, H.   +16 more
core  

Intrinsically Disordered Regions Define Unique Protein Interaction Networks in CHD Family Remodelers

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
The protein–protein interaction (PPI) networks were mapped for the intrinsically disordered N‐ and C‐termini of nine CHD family members. AlphaFold Multimer was used to predict interaction interfaces, with a focus on the interaction between the CHD4 C‐terminus and GATAD2B.
Mehdi Sharifi Tabar, Chirag Parsania, Caroline Giardina, Yue Feng, Alex C. H. Wong, Cynthia Metierre, Rajini Nagarajah, Bijay P. Dhungel, John E. J. Rasko, Charles G. Bailey   +9 more
wiley   +1 more source