Results 11 to 20 of about 22,197 (290)
The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution [PDF]
Background The lancelet amphioxus (Cephalochordata) is a close relative of vertebrates and thus may enhance our understanding of vertebrate gene and genome evolution.
Marden Michael C+6 more
doaj +5 more sources
Globin-based redox signaling [PDF]
In recent years, moderate levels of reactive oxygen species (ROS) have become recognized as signaling cues that participate at all levels of cellular organization. Globins, with their redox-active heme iron and ubiquitous presence, seem ideally suited to
Braeckman, Bart, De Henau, Sasha
core +7 more sources
A membrane-bound vertebrate globin.
The family of vertebrate globins includes hemoglobin, myoglobin, and other O(2)-binding proteins of yet unclear functions. Among these, globin X is restricted to fish and amphibians.
Miriam Blank+8 more
doaj +5 more sources
A Globin in the Nucleus! [PDF]
Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues. In the present study, polyclonal antibodies were raised against both proteins and the distribution of them was studied by ...
Geuens, Eva+5 more
openaire +4 more sources
Regulation of the Globin Genes [PDF]
The a- and b-globin gene clusters are subject to several levels of regulation. They are expressed exclusively in the erythroid cells, only during defined periods of development and in a perfectly tuned way, assuring, at any stage of ontogeny, a correct balance in the availability of a- and b-globin chains for hemoglobin assembling. Such a tight control
Cao A, MOI, PAOLO
openaire +3 more sources
TMEM8 – a non-globin gene entrapped in the globin web [PDF]
For more than 30 years it was believed that globin gene domains included only genes encoding globin chains. Here we show that in chickens, the domain of alpha-globin genes also harbor the non-globin gene TMEM8. It was relocated to the vicinity of the alpha-globin cluster due to inversion of an approximately 170-kb genomic fragment.
Elena S. Philonenko+5 more
openaire +3 more sources
Background How vascular systems and their respiratory pigments evolved is still debated. While many animals present a vascular system, hemoglobin exists as a blood pigment only in a few groups (vertebrates, annelids, a few arthropod and mollusk species).
Solène Song+6 more
doaj +1 more source
Challenges in the Diagnosis of Beta-thalassemia Syndrome: The Importance of Molecular Diagnosis
Patients with heterozygous β-thalassemia are generally asymptomatic. However, the intermediate phenotype is uncommon, and patients require further investigation to confirm the diagnosis.
Zefarina Zulkafli+7 more
doaj +1 more source
The folding pathway for globins [PDF]
Previous investigations have successfully predicted the three-dimensional structures of trypsin inhibitor [ 1,2] , myoglobin [3,4] , TMV protein [ 51 and rubredoxin [2]. Using mechanisms of protein chain folding which one of us [5 $1 suggested,.we can find a common folding pathway for the globins which are included in the ‘Atlas of Protein Sequence and
V.I. Lim, Alexander V. Efimov
openaire +3 more sources
Visible Volume: a Robust Measure for Protein Structure Characterization [PDF]
We propose a new characterization of protein structure based on the natural tetrahedral geometry of the β carbon and a new geometric measure of structural similarity, called visible volume.
Bashford+31 more
core +2 more sources