Results 11 to 20 of about 17,498 (250)
Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations
Antioxidants, 2022 Cytoglobin is a hexacoordinate hemoglobin with physiological roles that are not clearly understood. Previously proposed physiological functions include nitric oxide regulation, oxygen sensing, or/and protection against oxidative stress under hypoxic ...
John Ukeri +2 more
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BMC Evolutionary Biology, 2020 Background How vascular systems and their respiratory pigments evolved is still debated. While many animals present a vascular system, hemoglobin exists as a blood pigment only in a few groups (vertebrates, annelids, a few arthropod and mollusk species).
Solène Song +6 more
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Challenges in the Diagnosis of Beta-thalassemia Syndrome: The Importance of Molecular Diagnosis
Oman Medical Journal, 2022 Patients with heterozygous β-thalassemia are generally asymptomatic. However, the intermediate phenotype is uncommon, and patients require further investigation to confirm the diagnosis.
Zefarina Zulkafli +7 more
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A phylogenomic profile of globins
BMC Evolutionary Biology, 2006 Background Globins occur in all three kingdoms of life: they can be classified into single-domain globins and chimeric globins. The latter comprise the flavohemoglobins with a C-terminal FAD-binding domain and the gene-regulating globin coupled sensors ...
Dewilde Sylvia +7 more
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Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport
Redox Biology, 2020 Vertebrate hemoglobin (Hb) and myoglobin (Mb) were among the first proteins whose structures and sequences were determined over 50 years ago. In the subsequent pregenomic period, numerous related proteins came to light in plants, invertebrates and ...
Anna Keppner +6 more
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Redox Biology, 2022 Background & aims: Hepatic stellate cells (HSCs) are the primary cell type in liver fibrosis, a significant global health care burden. Cytoglobin (CYGB), a globin family member expressed in HSCs, inhibits HSC activation and reduces collagen ...
Vu Ngoc Hieu +14 more
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Nitric Oxide Trickle Drives Heme into Hemoglobin and Muscle Myoglobin
Cells, 2022 Ever since the days of NO being proclaimed as the “molecule of the year”, the molecular effects of this miracle gas on the globins have remained elusive.
Mamta P. Sumi, Blair Tupta, Arnab Ghosh
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BMC Genomics, 2007 Background The emergence of high throughput genome sequencing facilities and powerful high performance bioinformatic tools has highlighted hitherto unexpected wide occurrence of globins in the three kingdoms of life. In silico analysis of the genome of C.
Vinogradov Serge +6 more
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Revista Brasileira de Hematologia e Hemoterapia, 2010 Despite major advances in Brazilian blood transfusion therapy with a growing number of scientific publications, an increased number of repeat donors and a decline in serological ineligibility, a lack of conformity in the application of pre-transfusion ...
Aline A. Ferreira +3 more
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Nerve Globins in Invertebrates
IUBMB Life, 2004 AbstractThe expression of nerve hemoglobins in invertebrates is a well‐established fact, but this occurrence is uncommon. In the species where nerve globins occur, they probably function as an oxygen store for sustaining activity of the nerves during anoxic conditions.
GEUENS E. +9 more
openaire +5 more sources