Results 11 to 20 of about 7,527 (191)

PCA-Based Database Mining Enables the Discovery of Bacterial Carbene Transferases for Stereodivergent Cyclopropanation. [PDF]

Angew Chem Int Ed Engl
Database mining using principal component analysis (PCA)‐based clustering enabled discovery of bacterial enzymes capable of catalyzing stereodivergent cyclopropanation of styrene. Statistical analyses of sequence data further revealed characteristic structural properties of these enzymes, highlighting the potential of the bioinformatics tools for ...
Kato S, Takeuchi K, Umeda K, Kudo H, Hasunuma T, Hayashi T.   +5 more
europepmc   +3 more sources

Challenges in the Diagnosis of Beta-thalassemia Syndrome: The Importance of Molecular Diagnosis

Oman Medical Journal, 2022
Patients with heterozygous β-thalassemia are generally asymptomatic. However, the intermediate phenotype is uncommon, and patients require further investigation to confirm the diagnosis.
Zefarina Zulkafli, Mohd Nazri Hassan, Shafini Mohd Yusoff, Noor Haslina Mohd Noor, Suryati Hussin, Nor Khairina Mohamed Kamarudin, Yuslina Mat Yusoff, Rosnah Bahar   +7 more
doaj   +1 more source

A phylogenomic profile of globins

BMC Evolutionary Biology, 2006
Background Globins occur in all three kingdoms of life: they can be classified into single-domain globins and chimeric globins. The latter comprise the flavohemoglobins with a C-terminal FAD-binding domain and the gene-regulating globin coupled sensors ...
Dewilde Sylvia, Gough Julian, Arredondo-Peter Raúl, Bailly Xavier, Hoogewijs David, Vinogradov Serge N, Moens Luc, Vanfleteren Jacques R   +7 more
doaj   +1 more source

Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport

Redox Biology, 2020
Vertebrate hemoglobin (Hb) and myoglobin (Mb) were among the first proteins whose structures and sequences were determined over 50 years ago. In the subsequent pregenomic period, numerous related proteins came to light in plants, invertebrates and ...
Anna Keppner, Darko Maric, Miguel Correia, Teng Wei Koay, Ilaria M.C. Orlando, Serge N. Vinogradov, David Hoogewijs   +6 more
doaj   +1 more source

Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion

Redox Biology, 2022
Background & aims: Hepatic stellate cells (HSCs) are the primary cell type in liver fibrosis, a significant global health care burden. Cytoglobin (CYGB), a globin family member expressed in HSCs, inhibits HSC activation and reduces collagen ...
Vu Ngoc Hieu, Le Thi Thanh Thuy, Hoang Hai, Ninh Quoc Dat, Dinh Viet Hoang, Ngo Vinh Hanh, Dong Minh Phuong, Truong Huu Hoang, Hitomi Sawai, Yoshitsugu Shiro, Misako Sato-Matsubara, Daisuke Oikawa, Fuminori Tokunaga, Katsutoshi Yoshizato, Norifumi Kawada   +14 more
doaj   +1 more source

Nitric Oxide Trickle Drives Heme into Hemoglobin and Muscle Myoglobin

Cells, 2022
Ever since the days of NO being proclaimed as the “molecule of the year”, the molecular effects of this miracle gas on the globins have remained elusive.
Mamta P. Sumi, Blair Tupta, Arnab Ghosh
doaj   +1 more source

Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family

BMC Genomics, 2007
Background The emergence of high throughput genome sequencing facilities and powerful high performance bioinformatic tools has highlighted hitherto unexpected wide occurrence of globins in the three kingdoms of life. In silico analysis of the genome of C.
Vinogradov Serge, Moens Luc, Vierstraete Andy, Dewilde Sylvia, Geuens Eva, Hoogewijs David, Vanfleteren Jacques R   +6 more
doaj   +1 more source

Transfusão de plaquetas: do empirismo ao embasamento científico Platelet transfusion: from empiricism to scientific evidence

Revista Brasileira de Hematologia e Hemoterapia, 2010
Despite major advances in Brazilian blood transfusion therapy with a growing number of scientific publications, an increased number of repeat donors and a decline in serological ineligibility, a lack of conformity in the application of pre-transfusion ...
Aline A. Ferreira, Sheila Soares, Vagner de Castro, Helio Moraes-Souza   +3 more
doaj   +1 more source

Nerve Globins in Invertebrates

IUBMB Life, 2004
AbstractThe expression of nerve hemoglobins in invertebrates is a well‐established fact, but this occurrence is uncommon. In the species where nerve globins occur, they probably function as an oxygen store for sustaining activity of the nerves during anoxic conditions.
GEUENS E., DEWILDE S., HOOGEWIJS D., PESCE, ALESSANDRA, NIENHAUS K., NIENHAUS G. U., OLSON J., VANFLETEREN J., BOLOGNESI, MARTINO, MOENS L.   +9 more
openaire   +5 more sources

The emerging roles of somatic globins in cardiovascular redox biology and beyond

Redox Biology, 2013
The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology.
Mizanur M. Rahaman, Adam C. Straub
doaj   +1 more source