The primary structure of three hemoglobin chains from the indigo snake (Drymarchon corais erebennus, Serpentes): First evidence for αD chains and two β chain types in snakes [PDF]
, 2002 The hemoglobin of the indigo snake (Drymarchon corais erebennus, Colubrinae) consists of two components, HbA and HbD, in the ratio of 1:1. They differ in both their alpha and beta chains.
Abbasi A. +22 more
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Globin genes on the move [PDF]
Journal of Biology, 2008 Recent data published in BMC Biology from the globin gene clusters in platypus, together with data from other species, show that beta-globin genes transposed from one chromosomal location to another. This resolves some controversies about vertebrate globin gene evolution but ignites new ones.
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A novel high-content immunofluorescence assay as a tool to identify at the single cell level γ-globin inducing compounds [PDF]
, 2015 The identification of drugs capable of reactivating γ-globin to ameliorate β-thalassemia and Sickle Cell anemia is still a challenge, as available γ-globin inducers still have limited clinical indications.
Antonella Ronchi +14 more
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Resonance Raman Spectroscopy Reveals pH-Dependent Active Site Structural Changes of Lactoperoxidase Compound 0 and Its Ferryl Heme O–O Bond Cleavage Products [PDF]
, 2014 The first step in the enzymatic cycle of mammalian peroxidases, including lactoperoxidase (LPO), is binding of hydrogen peroxide to the ferric resting state to form a ferric-hydroperoxo intermediate designated as Compound 0, the residual proton ...
Kincaid, James R. +3 more
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Exploring three different expression systems for recombinant expression of globins: Escherichia coli, Pichia pastoris and Spodoptera frugiperda [PDF]
, 2018 Globins are among the best investigated proteins in biological and medical sciences and represent a prime tool for the study of the evolution of genes and the structure- function relationship of proteins.
Bracke, An +2 more
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Globin and Globin Gene Structure of the Nerve Myoglobin of Aphrodite aculeata [PDF]
Journal of Biological Chemistry, 1996 The globin of the nerve cord of the polychaete annelid Aphrodite aculeata was isolated and purified to homogeneity. The native molecule has a pI of 6.3 and acts as a dimer of two identical Mr 15, 644.5 polypeptide chains as determined by electrospray mass spectrometry.
Dewilde, Sylvia +7 more
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Human globin ψB2is not a globin-related sequence [PDF]
Nucleic Acids Research, 1982 We have determined the complete nucleotide sequence of 3.4 kilobase pairs of DNA covering the region of the human beta globin gene cluster where a human globin-related sequence psi beta 2 was thought to lie (Fritsch, Lawn, and Maniatis (1980) Cell 19, 959-972).
Shi hsiang Shen, Oliver Smithies
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A Phylogenetic Analysis of the Globins in Fungi [PDF]
PLoS ONE, 2012 All globins belong to one of three families: the F (flavohemoglobin) and S (sensor) families that exhibit the canonical 3/3 α-helical fold, and the T (truncated 3/3 fold) globins characterized by a shortened 2/2 α-helical fold. All eukaryote 3/3 hemoglobins are related to the bacterial single domain F globins.
Hoogewijs, D +4 more
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Zebrafish Globin Switching Occurs in Two Developmental Stages and Is Controlled by the LCR [PDF]
, 2014 Globin gene switching is a complex, highly regulated process allowing expression of distinct globin genes at specific developmental stages. Here, for the first time, we have characterized all of the zebrafish globins based on the completed genomic ...
de Jong, Jill L.O. +12 more
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Proceedings of the National Academy of Sciences, 2006 A crucial requirement of metabolically active aerobic cells is a steady supply of oxygen. The red pigment of vertebrate skeletal muscle, oxygen-binding myoglobin (Mb), serves this function by facilitating the delivery of O 2 from the plasma membrane to the energy-producing mitochondria (1). The delivery of O2 from lungs or gills to muscles is also very
Thomas A. Gorr, Austen Riggs
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