Results 21 to 30 of about 17,498 (250)

The emerging roles of somatic globins in cardiovascular redox biology and beyond

Redox Biology, 2013
The vertebrate globins are a group of hemoproteins with the intrinsic capacity to regulate gaseous ligands and redox signaling required for cardiovascular biology.
Mizanur M. Rahaman, Adam C. Straub
doaj   +1 more source

Globins in Caenorhabditis elegans

IUBMB Life, 2011
AbstractExtensive in silico search of the genome of Caenorhabditis elegans revealed the presence of 33 genes coding for globins that are all transcribed. These globins are very diverse in gene and protein structure and are localized in a variety of cells, mostly neurons. The large number of C.
Tilleman, L, Germani, F, De Henau, S, Geuens, E, Hoogewijs, D, Braeckman, B P, Vanfleteren, J R, Moens, L, Dewilde, S   +8 more
openaire   +5 more sources

A Novel Alpha1-Variant (HBA1:c.-35T>C) Complexed With the First Reported Hb M-Saskatoon in the Chinese Population. [PDF]

Mol Genet Genomic Med
The research subjects were diagnosed with two distinct types of abnormal hemoglobin. Our study reports the first case of a complex hemoglobinopathy in China, characterized by the presence of the globally first‐reported alpha1 variant (HBA1:c.‐35T>C) and the initial identification of Hb M‐Saskatoon (HBB:c.190C>T) in China.
Yang Y, Zhao Y, Luan L, Li G, Deng Q, Ge Y.   +5 more
europepmc   +2 more sources

Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom. [PDF]

PLoS ONE, 2011
Caenorhabditis elegans globin GLB-26 (expressed from gene T22C1.2) has been studied in comparison with human neuroglobin (Ngb) and cytoglobin (Cygb) for its electron transfer properties. GLB-26 exhibits no reversible binding for O(2) and a relatively low
Laurent Kiger, Lesley Tilleman, Eva Geuens, David Hoogewijs, Christophe Lechauve, Luc Moens, Sylvia Dewilde, Michael C Marden   +7 more
doaj   +1 more source

Gelling Properties of Globin-Succinylated Globin Conjugates.

NIPPON SHOKUHIN KOGYO GAKKAISHI, 1993
2種類のグロビン-サクシニル化グロビン複合体(CMHTとCUT)を調製し,各複合体のゲル特性について検討した.(1) CMHTはGの配合比率が高くなる程ゲル形成pHは中性の方へ拡大した.例えば, GとSGの配合率が3:7の場合,ゲル形成pHは2.0であったが,G:SG=9:1の場合,ゲルはpH 2.0～3.5の範囲で形成された.一方, G:SGの配合比率が7:3と9:1のCUTの場合,ゲル形成pHは極めて狭い範囲に限定された.(2) ゲルの透明度はCMHT, CUTともにより酸性側で高く,また,グロビンの配合比率が高くなる程透明度も高くなる傾向を示した.(3) 複合体ゲルのゲル強度を測定した. CMHTの場合, G:SG=5:5 (pH 2.0)で高いゲル強度が得られた.
Yuji MIYAGUCHI, Toyoo NAKAMURA, Satoru TAKABATAKE, Masami YONEKURA, Masakazu TSUTSUMI   +4 more
openaire   +2 more sources

Hemoglobin switching in mice carrying the Klf1^Nan variant

Haematologica, 2020
Haploinsufficiency for transcription factor KLF1 causes a variety of human erythroid phenotypes, such as the In(Lu) blood type, increased HbA2 levels, and hereditary persistence of fetal hemoglobin. Severe dominant congenital dyserythropoietic anemia IV
Anne Korporaal, Nynke Gillemans, Steven Heshusius, Ileana Cantú, Emile van den Akker, Thamar B. van Dijk, Marieke von Lindern, Sjaak Philipsen   +7 more
doaj   +1 more source

ACTIVIN RECEPTOR LIGAND FOR THR TREATMENT OF BETA-THALASSEMIA: a SERENDIPITOUS DISCOVERY

Mediterranean Journal of Hematology and Infectious Diseases, 2020
b-thalassemia is a hereditary disorder caused by defective production of b-globin chains of hemoglobin (Hb) that leads to an increased a/b globins ratio with subsequent free a-globins.
Irene Motta, Valentina Brancaleoni, Isabella Nava, Paola Delbini, Lorena Duca   +4 more
doaj   +1 more source

Redox-Regulation of α-Globin in Vascular Physiology

Antioxidants, 2022
Interest in the structure, function, and evolutionary relations of circulating and intracellular globins dates back more than 60 years to the first determination of the three-dimensional structure of these proteins.
Laurent Kiger, Julia Keith, Abdullah Freiwan, Alfonso G. Fernandez, Heather Tillman, Brant E. Isakson, Mitchell J. Weiss, Christophe Lechauve   +7 more
doaj   +1 more source

Engineering Globin Gene Expression [PDF]

Molecular Therapy - Methods & Clinical Development, 2019
Hemoglobinopathies, including sickle cell disease and thalassemia, are among the most common inherited genetic diseases worldwide. Due to the relative ease of isolating and genetically modifying hematopoietic stem and progenitor cells, recent gene editing and gene therapy strategies have progressed to clinical trials with promising outcomes; however ...
Rachael Davis, Aishwarya Gurumurthy, Mir A. Hossain, Eliot M. Gunn, Jörg Bungert   +4 more
openaire   +3 more sources

Nitrophorins and nitrobindins: structure and function

Biomolecular Concepts, 2017
Classical all α-helical globins are present in all living organisms and are ordered in three lineages: (i) flavohemoglobins and single domain globins, (ii) protoglobins and globin coupled sensors and (iii) truncated hemoglobins, displaying the 3/3 or the
De Simone Giovanna, Ascenzi Paolo, di Masi Alessandra, Polticelli Fabio   +3 more
doaj   +1 more source