Results 41 to 50 of about 11,873 (185)
Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A Motif in electron cycling [PDF]
, 2014 Background: The HbN of Mycobacterium tuberculosis carries a potent nitric-oxide dioxygenase activity despite lacking a reductase domain. Results: The NADH-ferredoxin reductase system acts as an efficient partner for the reduction of HbN.
Bidon Chanal, Axel +12 more
core +2 more sources
Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
Engineering Globin Gene Expression [PDF]
Molecular Therapy - Methods & Clinical Development, 2019 Hemoglobinopathies, including sickle cell disease and thalassemia, are among the most common inherited genetic diseases worldwide. Due to the relative ease of isolating and genetically modifying hematopoietic stem and progenitor cells, recent gene editing and gene therapy strategies have progressed to clinical trials with promising outcomes; however ...
Jörg Bungert +4 more
openaire +4 more sources
Enhancer‐dependent gene regulation in space, time, and malignancies
International Journal of Cancer, EarlyView.Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum +2 more
wiley +1 more source
A pH Dependant Switch in DHP Oxidation Mechanism [PDF]
, 2017 Dehaloperoxidase (DHP) is a multifunctional enzyme found in Amphitrite ornata, a sediment-dwelling marine worm. This enzyme possess the structure of a traditional hemoglobin enzyme and serves as the primary oxygen carrier in A.
Fehr, Travis
core +1 more source
Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response [PDF]
, 2014 Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue.
Floros, Joanna +7 more
core +1 more source
Quantitation of human gamma globin genes and gamma globin mRNA with purified gamma globin complementary DNA. [PDF]
Journal of Clinical Investigation, 1976 Complementary DNA (cDNA) specific for gamma-globin nucleotide sequences has been prepared by hybridizing total cDNA made from cord blood messenger RNA (mRNA) as template to an excess of normal adult human globin mRNA and recovering the single-stranded cDNA from hydroxylapatite.
Clayton Natta +3 more
openaire +3 more sources
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective The aim of this study was to evaluate the performance of HPV type restriction and cycle threshold (Ct)‐limit setting to optimize detection of cervical intraepithelial neoplasia (CIN) with primary HPV testing. Methods Baseline cervical screening at time of entry into a prospective longitudinal cohort of women with and without HIV was ...
Rebecca Luckett +16 more
wiley +1 more source
Plant hemoglobins can be maintained in functional form by reduced flavins in the nuclei and confer differential tolerance to nitro-oxidative stress [PDF]
, 2013 39 Pags., 1 Tabl., 5 Figs., with Supplementary Supporting Information (1 Suppl. Tabl., 5 Suppl. Figs.). The definitive version is available at: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-313XThe heme of bacteria, plant and animal ...
Becana Ausejo, Manuel +7 more
core +2 more sources
The diversity of globin‐coupled sensors [PDF]
FEBS Letters, 2003 The recently discovered globin‐coupled sensors (GCSs) are heme‐containing two‐domain transducers distinct from the PAS domain superfamily. We have identified an additional 22 GCSs with varying multi‐domain C‐terminal transmitters through a search of the complete and incomplete microbial genome datasets.
Maqsudul Alam +2 more
openaire +3 more sources