Results 51 to 60 of about 7,527 (191)

TMEM8 – a non-globin gene entrapped in the globin web [PDF]

Nucleic Acids Research, 2009
For more than 30 years it was believed that globin gene domains included only genes encoding globin chains. Here we show that in chickens, the domain of alpha-globin genes also harbor the non-globin gene TMEM8. It was relocated to the vicinity of the alpha-globin cluster due to inversion of an approximately 170-kb genomic fragment.
Philonenko, Elena S., Klochkov, Denis B., Borunova, Victoria V., Gavrilov, Alexey A., Razin, Sergey V., Iarovaia, Olga V.   +5 more
openaire   +2 more sources

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Regulation of the Globin Genes [PDF]

Pediatric Research, 2002
The a- and b-globin gene clusters are subject to several levels of regulation. They are expressed exclusively in the erythroid cells, only during defined periods of development and in a perfectly tuned way, assuring, at any stage of ontogeny, a correct balance in the availability of a- and b-globin chains for hemoglobin assembling. Such a tight control
Cao A, MOI, PAOLO
openaire   +3 more sources

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel, Vanessa Bellegarde, Stennio Da Silva Faria, Tristan St‐Laurent, Estelle Lecluze, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Frédéric Galactéros, Pablo Bartolucci, Marc‐André Legault, Guillaume Lettre, Thomas Pincez   +10 more
wiley   +1 more source

Neuroglobin and cytoglobin: two new members of globin family

Revista Brasileira de Hematologia e Hemoterapia, 2011
The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal ...
Priscilla Tosqui, Marcio Francisco Colombo   +1 more
doaj   +1 more source

Iron metabolic pathways in the processes of sponge plasticity.

PLoS ONE, 2020
The ability to regulate oxygen consumption evolved in ancestral animals and is intrinsically linked to iron metabolism. The iron pathways have been intensively studied in mammals, whereas data on distant invertebrates are limited.
Alexander D Finoshin, Kim I Adameyko, Kirill V Mikhailov, Oksana I Kravchuk, Anton A Georgiev, Nicolay G Gornostaev, Igor A Kosevich, Victor S Mikhailov, Guzel R Gazizova, Elena I Shagimardanova, Oleg A Gusev, Yulia V Lyupina   +11 more
doaj   +1 more source

Combined Long‐Read Genome and Transcriptome Sequencing Establishes Novel Variants in MEGF8 as the Cause for Carpenter Syndrome Type 2

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Carpenter syndrome type 2 (CRPT2) is a rare autosomal recessive disease mainly characterized by craniosynostosis and polysyndactyly. CRPT2 is the rarer subtype of Carpenter syndrome (CRPTS) and is caused by biallelic variants in the multiple epidermal growth factor‐like domains 8 gene (MEGF8).
Kiana Rashidi, Bhavi P. Modi, Phillip A. Richmond, Massimo Mangino, Loryn Byres, Cassie McDonald, Joshua Dalmann, Simran Samra, Kate L. Del Bel, Anna Lehman, Jessica L. Zambonin, Stuart E. Turvey   +11 more
wiley   +1 more source

Monodisperse 130 kDa and 260 kDa Recombinant Human Hemoglobin Polymers as Scaffolds for Protein Engineering of Hemoglobin-Based Oxygen Carriers

Journal of Functional Biomaterials, 2012
A recombinant 130 kDa dihemoglobin which is made up of a single-chain tetra-α globin and four β globins has been expressed as a soluble protein in E. coli. The sequence of the single chain tetra-α is: αI-Gly-αII-(SerGlyGly)5Ser-αIII-Gly-αIV.
Jacqueline F. Aitken, Spencer J. Anthony-Cahill, Douglas D. Lemon, Michael P. Doyle, David A. Marquardt, Jeffrey S. Davidson, Janet K. Epp   +6 more
doaj   +1 more source

The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution

BMC Evolutionary Biology, 2010
Background The lancelet amphioxus (Cephalochordata) is a close relative of vertebrates and thus may enhance our understanding of vertebrate gene and genome evolution.
Marden Michael C, Kiger Laurent, Vinogradov Serge N, Panopoulou Georgia, Ebner Bettina, Burmester Thorsten, Hankeln Thomas   +6 more
doaj   +1 more source

A membrane-bound vertebrate globin.

PLoS ONE, 2011
The family of vertebrate globins includes hemoglobin, myoglobin, and other O(2)-binding proteins of yet unclear functions. Among these, globin X is restricted to fish and amphibians.
Miriam Blank, Jessica Wollberg, Frank Gerlach, Katja Reimann, Anja Roesner, Thomas Hankeln, Angela Fago, Roy E Weber, Thorsten Burmester   +8 more
doaj   +1 more source