Results 61 to 70 of about 11,873 (185)

Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

Aging Cell, EarlyView.
Age‐related increases in IGF‐1 expression in the skin accelerate stem cell exhaustion and senescence by impairing SIRT1 function, ultimately driving hair follicle aging. Conversely, activating SIRT1, clearing senescent cells, or adopting dietary restriction can mitigate excessive IGF‐1 signaling and provide a promising strategy to rejuvenate hair ...
Yang Wang, Jian Yang, Yue Luo, Zhiqiang Zhao, Yawen Yuan, Juan Li, Yang Liu, Yong Yi, Xiaoke Xu, Yuankunyu Lan, Juan Zou, Qintong Li, Liang Wang, Yang Pan, Yuanhan Yang, Muzhao Xiong, Min Wu, Jinsong Li, Weiyuxin Li, Yujun Zhang, Yang Cao, Yi Zhu, Zhi‐Xiong Jim Xiao   +22 more
wiley   +1 more source

Reactions of HNO with Metal Porphyrins: Underscoring the Biological Relevance of HNO [PDF]

, 2014
Azanone (1 HNO, nitroxyl) shows interesting yet poorly understood chemical and biological effects. HNO has some overlapping properties with nitric oxide (NO), sharing its biological reactivity toward heme proteins, thiols, and oxygen.
Bikiel, Damian Ezequiel, Doctorovich, Fabio, Marti, Marcelo Adrian, Pellegrino, Juan, Suarez, Sebastian   +4 more
core   +1 more source

Age and Sex Effects on Blood Retrotransposable Element Expression Levels: Findings From the Population‐Based Rhineland Study

Aging Cell, EarlyView.
Retrotransposable element (RTE) expression increases with chronological and biological age and is negatively associated with heterochromatin regulators. Moreover, RTE expression shows sex‐specific differences, with higher levels in men and enrichment for immune‐related pathways.
Valentina Talevi, Hang‐Mao Lee, Dan Liu, Marc D. Beyer, Paolo Salomoni, Monique M. B. Breteler, N. Ahmad Aziz   +6 more
wiley   +1 more source

Nitrite binding to globins: linkage isomerism, EPR silence and reductive chemistry [PDF]

, 2014
The nitrite adducts of globins can potentially bind via O- or N- linkage to the heme iron. We have used EPR (electron paramagnetic resonance) and DFT (density functional theory) to explore these binding modes to myoglobin and hemoglobin.
Allen, Antonini, Basu, Becke, Chris E. Cooper, Copeland, Cristina Bischin, Daniela Cioloboc, Dimitri A. Svistunenko, Dunne, Dunne, Einsle, Florina Scurtu, Frisch, George, Gladwin, Gladwin, Goetz, Goetz, Huang, Huang, Kim-Shapiro, Nagababu, Nagababu, Nurizzo, Palmer, Perdew, Perissinotti, Radu Silaghi-Dumitrescu, Ranghino, Reeder, Richter, Salgado, Salgado, Schwab, Schwab, Silaghi-Dumitrescu, Silaghi-Dumitrescu, Silaghi-Dumitrescu, Silaghi-Dumitrescu, Silaghi-Dumitrescu, Silaghi-Dumitrescu, Silaghi-Dumitrescu, Silaghi-Dumitrescu, Svistunenko, Williams, Yi, Yi, Yi, Young   +49 more
core   +1 more source

Reproductive functions and fertility preservation in men with sickle cell disease

Andrology, EarlyView.
Abstract Background Sickle cell disease (SCD) is a prevalent hereditary disorder with significant morbidity, including potential impacts on male fertility. This study aims to evaluate the semen parameters in men with SCD and assess the outcomes of fertility preservation strategies.
Clarisse Leblanc, Nathalie Sermondade, Diane Rivet‐Danon, Ludmilla Aworet‐Ogouma, Anna Ly, Guillaume Bachelot, Françoise Lionnet, Aline Santin, Anne‐Gael Cordier, Kamila Kolanska, Rachel Lévy, Isabelle Berthaut, Charlotte Dupont   +12 more
wiley   +1 more source

Molecular simulations of globins: Exploring the relationship between structure, dynamics and function [PDF]

, 2011
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392The discovery in the last two decades of novel members of the globin superfamily has challenged the conventional view about the structure and function of globins.
Arroyo, Pau, Bidon-Chanal Badia, Axel, Bikiel, Damian, Boechi, Leonardo, Capece, Luciana, Estrín, Darío, Forti, Flavio, Luque Garriga, F. Xavier, Martí, Marcelo A., Nadra, Alejandro, Novo de Oliveira, Ana Luísa   +10 more
core  

HisE11 and HisF8 Provide Bis-histidyl Heme Hexa-coordination in the Globin Domain of Geobacter sulfurreducens Globin-coupled Sensor [PDF]

, 2009
Among heme-based sensors, recent phylogenomic and sequence analyses have identified 34 globin coupled sensors (GCS), to which an aerotactic or gene-regulating function has been tentatively ascribed.
ALAM M, ASCENZI P, BOLLI A, BOLOGNESI M, COLETTA M, DESMET F, DEWILDE S., GOURLAY L, MOENS L, NARDINI M, PESCE, ALESSANDRA, SISINNI L, THIJS L, VAN DOORSLAER S, WAN X   +14 more
core   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Template Activity for Globin and Non-Globin Protein Synthesis in Reticulocytes

Journal of Biological Chemistry, 1972
Factors which control the rate of synthesis of two distinct classes of protein, globin and non-globin proteins, by free reticulocyte ribosomes have been investigated. Three different inhibitors of protein synthesis, puromycin, cycloheximide, and hydroxylamine, were more effective in inhibiting the synthesis of globin than of non-globin protein by free ...
Stephen I. Bulova, Edward R. Burka
openaire   +3 more sources

The wider perspective: Barriers and recommendations for transfusion support for patients with sickle cell disease in low‐ and middle‐income countries

British Journal of Haematology, EarlyView.
Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs, Luiz Amorim, France Pirenne, Claude Tayou, Ijele Adimora, Lydia H. Pecker, Aaron A. R. Tobian, Jeannie Callum, Julie Makani, Mark T. Gladwin, Meghan Delaney, Darrell J. Triulzi, Isaac Odame, Evan M. Bloch   +13 more
wiley   +1 more source