Results 61 to 70 of about 17,498 (250)

The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution

BMC Evolutionary Biology, 2010
Background The lancelet amphioxus (Cephalochordata) is a close relative of vertebrates and thus may enhance our understanding of vertebrate gene and genome evolution.
Marden Michael C, Kiger Laurent, Vinogradov Serge N, Panopoulou Georgia, Ebner Bettina, Burmester Thorsten, Hankeln Thomas   +6 more
doaj   +1 more source

A membrane-bound vertebrate globin.

PLoS ONE, 2011
The family of vertebrate globins includes hemoglobin, myoglobin, and other O(2)-binding proteins of yet unclear functions. Among these, globin X is restricted to fish and amphibians.
Miriam Blank, Jessica Wollberg, Frank Gerlach, Katja Reimann, Anja Roesner, Thomas Hankeln, Angela Fago, Roy E Weber, Thorsten Burmester   +8 more
doaj   +1 more source

Comparative genomics of neuroglobin reveals its early origins. [PDF]

PLoS ONE, 2012
Neuroglobin (Ngb) is a hexacoordinated globin expressed mainly in the central and peripheral nervous system of vertebrates. Although several hypotheses have been put forward regarding the role of neuroglobin, its definite function remains uncertain.
Jasmin Dröge, Amit Pande, Ella W Englander, Wojciech Makałowski   +3 more
doaj   +1 more source

Globin Gene Switching in Transgenic Mice Carrying HS2-Globin Gene Constructs [PDF]

Blood, 1997
Abstract We have examined the pattern of human globin gene switching in transgenic mice containing three different γ and β gene constructs (HS2GγAγδβ, HS2Aγβneo, and HS2Aγenβ) and compared the results with previously described transgenics (HS2Aγβ, HS2GγAγ-117δβ, and LCRεGγAγδβ).
N A, Roberts, J A, Sloane-Stanley, J A, Sharpe, S J, Stanworth, W G, Wood   +4 more
openaire   +2 more sources

Scalable production and biophysical characterization of an enzyme cocktail derived from human red blood cells

Biotechnology Progress, EarlyView.
Abstract Red blood cells (RBCs) play a critical role in oxygen and carbon dioxide transport, which is facilitated by RBC‐encapsulated hemoglobin (Hb) and carbonic anhydrase (CA). In addition, RBCs are constantly exposed to oxidative stress due to the intracellular reactive oxygen species (ROS) generated during Hb auto‐oxidation.
Mohd Asim Khan, Griffin J. Beyer, Naomi Goosby, Lilly Ortiz, Andre F. Palmer   +4 more
wiley   +1 more source

Neuroglobina: nuevo miembro de la familia de las globinas Neuroglobin: a novel member of the globin family

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2011
Durante mucho tiempo se asumió que la hemoglobina y la mioglobina eran las únicas globinas de los vertebrados. En el año 2000 se descubrió un tercer tipo de globina, que sobre la base de su ubicación preferencial en el sistema nervioso fue denominada ...
Mariela Forrellat Barrios, Porfirio Hernández Ramírez   +1 more
doaj  

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Human globin ψB₂is not a globin-related sequence [PDF]

Nucleic Acids Research, 1982
We have determined the complete nucleotide sequence of 3.4 kilobase pairs of DNA covering the region of the human beta globin gene cluster where a human globin-related sequence psi beta 2 was thought to lie (Fritsch, Lawn, and Maniatis (1980) Cell 19, 959-972).
S H, Shen, O, Smithies
openaire   +2 more sources

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Canalization of globins in the adaptive evolution of birds

Avian Research
The globin superfamily, central to oxygen (O2) cascade dynamics, exemplifies how canalization—evolutionary stabilization of phenotypic traits—enables vertebrates to thrive in extreme environments.
Xiaojia Zhu, Le Yang, Quanjian Tao, Xiran Wang, Ghulam Nabi, Fumin Lei, Xiaoping Yu, Dongming Li   +7 more
doaj   +1 more source