Results 81 to 90 of about 11,873 (185)
The Journal of Physiology, EarlyView.Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida +4 more
wiley +1 more source
, 2003 The aim of this thesis was to gain a detailed understanding of transcriptional regulation in the context of the living cell. The ß-globin locus was used as a model system to study the question: how distal cisregulatory DNA elements communicate to ...
Tolhuis, B.J. (Bas)
core +2 more sources
, 2014 The Amoebozoa represent a clade of unicellular amoeboid organisms that display a wide variety of lifestyles, including free-living and parasitic species.
Buczek, D. (Dorota) +3 more
core +1 more source
Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1640-1655, July 2025.ABSTRACT Recombinant adeno associated virus (rAAV) vectors have become popular delivery vehicles for in vivo gene therapies, but demand for rAAVs continues to outpace supply. Platform processes for rAAV production are being developed by many manufacturers, and transient chemical transfection of human embryonic kidney 293 (HEK293) cells is currently the
Erica A. Green +9 more
wiley +1 more source
GATA Transcription Factors: A Cross‐Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies
Developmental Neurobiology, Volume 85, Issue 3, July 2025.ABSTRACT Alpha‐synuclein (α‐syn), a 140 amino acid protein, is abundantly expressed in the central nervous system (CNS) and in the erythrocytes, playing a pivotal role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies.
Francesco Bellomi +7 more
wiley +1 more source
The transcription factor RIP140 regulates interferon γ signaling in breast cancer
International Journal of Cancer, Volume 157, Issue 1, Page 170-182, 1 July 2025.What's new? Interferon γ (IFNγ) is a key player in breast cancer, with the potential to induce apoptosis and to shift tumors into a dormant state. However, it also may promote carcinogenesis and angiogenesis. In this study, transcriptomic analysis identified the transcription factor RIP140 as a key regulator of IFNγ signaling in breast cancer.
Stéphan Jalaguier +9 more
wiley +1 more source
The adaptive evolution of polar fishes: Structure, function and molecular phylogeny of hemoglobin [PDF]
, 2006 emperature affects all molecular processes and is the major determinant of habitat suitability. Whilst there is an increasing understanding of evolutionary adaptation to temperature in some processes, several key questions often remain open about the ...
Di Prisco, Guido, Verde, Cinzia
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Antenatal medication management for women with sickle‐cell disease: A systematic review
Pregnancy, Volume 1, Issue 4, July 2025.Abstract Background Improvements in sickle‐cell disease (SCD) treatment have led to an increasing number of individuals surviving to reproductive age. However, pregnancy in women with SCD carries a heightened risk of maternal and fetal complications.
Yaneve N. Fonge +10 more
wiley +1 more source
Molecular Ecology Resources, Volume 25, Issue 5, July 2025.Abstract Infectious diseases impact numerous organisms. Knowledge of host‐pathogen interactions and host responses to infection is crucial for conservation and management. Obtaining this knowledge quickly is made increasingly possible by a variety of genomic approaches, yet, for many species the bottleneck to understanding this, remains access to ...
Allison K. Miller +7 more
wiley +1 more source
Potential New Expression Biomarkers for Anorexia Nervosa
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 4, June 2025.ABSTRACT Anorexia nervosa (AN) is a psychiatric disorder with an estimated heritability of around 70%. Although the largest meta‐analysis of genome‐wide association studies on AN identified independent risk‐conferring loci for the disorder, the molecular mechanisms underlying the genetic basis of AN remain to be elucidated.
Camille Verebi +8 more
wiley +1 more source