Results 21 to 30 of about 39,168 (261)

Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities

Frontiers in Physiology, 2021
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang, Bohan Chen, James Shaffner, Lance D. Dworkin, Rujun Gong   +4 more
doaj   +1 more source

Bioinformatics Analysis Reveals Crosstalk Among Platelets, Immune Cells, and the Glomerulus That May Play an Important Role in the Development of Diabetic Nephropathy

Frontiers in Medicine, 2021
Diabetic nephropathy (DN) is the main cause of end stage renal disease (ESRD). Glomerulus damage is one of the primary pathological changes in DN. To reveal the gene expression alteration in the glomerulus involved in DN development, we screened the Gene
Xinyue Yao, Hong Shen, Fukai Cao, Hailan He, Boyu Li, Haojun Zhang, Xinduo Zhang, Zhiguo Li   +7 more
doaj   +1 more source

Functional Reintegration of Sensory Neurons and Transitional Dendritic Reduction of Mitral/Tufted Cells during Injury-Induced Recovery of the Larval Xenopus Olfactory Circuit

Frontiers in Cellular Neuroscience, 2017
Understanding the mechanisms involved in maintaining lifelong neurogenesis has a clear biological and clinical interest. In the present study, we performed olfactory nerve transection on larval Xenopus to induce severe damage to the olfactory circuitry ...
Sara J. Hawkins, Sara J. Hawkins, Lukas Weiss, Lukas Weiss, Thomas Offner, Thomas Offner, Katarina Dittrich, Katarina Dittrich, Thomas Hassenklöver, Thomas Hassenklöver, Thomas Hassenklöver, Ivan Manzini, Ivan Manzini, Ivan Manzini   +13 more
doaj   +1 more source

Molecular and Cellular Mechanisms Underlying the Initiation and Progression of Alport Glomerular Pathology

Frontiers in Medicine, 2022
Alport syndrome results from a myriad of variants in the COL4A3, COL4A4, or COL4A5 genes that encode type IV (basement membrane) collagens. Unlike type IV collagen α1(IV)2α2(IV)1 heterotrimers, which are ubiquitous in basement membranes, α3/α4/α5 have a ...
Dominic Cosgrove, Jacob Madison
doaj   +1 more source

Kidney sphaerosporosis with extrasporogonic stages in the blood in Baryancistrus sp. (Loricaridae) from Amazonian Brazil

Parasite, 2001
Examined fish of the genus Baryancistrus (Loricaridae) from Rio Xingu in central amazonian Brazil were found infected with extrasporogonic stages of Sphaerospora sp.
Paperna I., Di Cave D.
doaj   +1 more source

Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney

Frontiers in Medicine, 2020
Molecular assessments at the single cell level can accelerate biological research by providing detailed assessments of cellular organization and tissue heterogeneity in both disease and health.
Tara K. Sigdel, Paul D. Piehowski, Sudeshna Roy, Juliane Liberto, Joshua R. Hansen, Adam C. Swensen, Rui Zhao, Ying Zhu, Priyanka Rashmi, Andrew Schroeder, Izabella Damm, Swastika Sur, Jinghui Luo, Yingbao Yang, Wei-Jun Qian, Minnie M. Sarwal, The Kidney Precision Medicine Project (KPMP) Consortium   +16 more
doaj   +1 more source

Fine particulate matter (PM2.5) induces microRNA-192–5p causing glomerular damage

Ecotoxicology and Environmental Safety
An association between air pollution and the incidence of membranous glomerulonephritis (MGN) has been shown in epidemiological studies. However, the causality of this relationship and data on potential pathomechanisms are still missing.
Melina Yarbakht, George Sarau, Yanyi Xu, Xinyi Fang, Zeynab Mirzaei, René Krüger, Yalan Xiao, Arslan Usman, Christoph Daniel, Mario Schiffer, Silke Christiansen, Janina Müller-Deile   +11 more
doaj   +1 more source

A comparative analysis of glomerulus development in the pronephros of medaka and zebrafish.

PLoS ONE, 2012
The glomerulus of the vertebrate kidney links the vasculature to the excretory system and produces the primary urine. It is a component of every single nephron in the complex mammalian metanephros and also in the primitive pronephros of fish and ...
Koichiro Ichimura, Ekaterina Bubenshchikova, Rebecca Powell, Yayoi Fukuyo, Tomomi Nakamura, Uyen Tran, Shoji Oda, Minoru Tanaka, Oliver Wessely, Hidetake Kurihara, Tatsuo Sakai, Tomoko Obara   +11 more
doaj   +1 more source

Glomerulogenesis and Histomorphometeric in Mus musculus Embryo

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2023
In mammals, the kidneys originate in an embryo from the mesoderm through three excretory organs, namely: Pronephros, Mesonephros, and Metanephros.
Amar Alzubaidi, Nahla A. Al-Bakri , Ateeq M. J. Alarami   +2 more
doaj   +1 more source

Research Progress of Drug Delivery Systems Targeting the Kidneys

Pharmaceuticals
Chronic kidney disease (CKD) affects more than 10% of the global population, and its incidence is increasing, partially due to an increase in the prevalence of disease risk factors.
Li-Feng Huang, Qiao-Ru Ye, Xiao-Cui Chen, Xiao-Rong Huang, Qiao-Fei Zhang, Chun-Yu Wu, Hua-Feng Liu, Chen Yang   +7 more
doaj   +1 more source