Results 31 to 40 of about 68,068 (346)

The Glomerulus [PDF]

Clinical Journal of the American Society of Nephrology, 2014
The glomerulus, the filtering unit of the kidney, is a unique bundle of capillaries lined by delicate fenestrated endothelia, a complex mesh of proteins that serve as the glomerular basement membrane and specialized visceral epithelial cells that form the slit diaphragms between interdigitating foot processes.
Martin R, Pollak, Susan E, Quaggin, Melanie P, Hoenig, Lance D, Dworkin   +3 more
openaire   +2 more sources

Single Cell Transcriptome Helps Better Understanding Crosstalk in Diabetic Kidney Disease

Frontiers in Medicine, 2021
Years of research revealed that crosstalk extensively existed among kidney cells, cell factors and metabolites and played an important role in the development of diabetic kidney disease (DKD). In the last few years, single-cell RNA sequencing (scRNA-seq)
Chunyang Du, Yunzhuo Ren, Guixin Li, Yan Yang, Zhe Yan, Fang Yao   +5 more
doaj   +1 more source

Effects of Raw Ethanolic Seed Extract of Tetracarpidium conophorum on Heamatological and Histopathological Parameters in Swiss Albino Mice Infected with Plasmodium berghei [PDF]

, 2017
Study was carried out to determine the heamatological and histopathological effects of raw ethanolic seed extract of Tetracarpidium conophorum in swiss albino mice infected with Plasmodium berghei (NK65).
D. A. Oloruntola, E. O. Dada, I. B. Osho, O. O. Ogundolie   +3 more
core   +1 more source

Application of direct stochastic optical reconstruction microscopy (dSTORM) to the histological analysis of human glomerular disease

The Journal of Pathology: Clinical Research, 2021
Electron microscopy (EM) following immunofluorescence (IF) imaging is a vital tool for the diagnosis of human glomerular diseases, but the implementation of EM is limited to specialised institutions and it is not available in many countries.
Edwin Garcia, Jonathan Lightley, Sunil Kumar, Ranjan Kalita, Frederik Gőrlitz, Yuriy Alexandrov, Terry Cook, Christopher Dunsby, Mark AA Neil, Candice A Roufosse, Paul MW French   +10 more
doaj   +1 more source

Upregulation of Transglutaminase andε(γ-Glutamyl)-Lysine in the Fisher-Lewis Rat Model of Chronic Allograft Nephropathy [PDF]

, 2014
Background. Tissue transglutaminase (TG2), a cross-linking enzyme, modulates deposition of extracellular matrix protein in renal fibrosis. This study aimed to examine TG2 and its cross-link product ε(γ-glutamyl)-lysine in the Fisher-Lewis rat renal ...
Butt, Imran, Da Silva, Michelle, Haylor, John, Johnson, Timothy, Raftery, Andrew, Sanchez-Lara, Armando, Shrestha, Badri, Wagner, Bart   +7 more
core   +3 more sources

Co-Culture of Glomerular Endothelial Cells and Podocytes in a Custom-Designed Glomerulus-on-a-Chip Model Improves the Filtration Barrier Integrity and Affects the Glomerular Cell Phenotype

Biosensors, 2023
Crosstalk between glomerular endothelial cells and glomerular epithelial cells (podocytes) is increasingly becoming apparent as a crucial mechanism to maintain the integrity of the glomerular filtration barrier.
Daan C. ‘t Hart, Dilemin Yildiz, Valentina Palacio-Castañeda, Lanhui Li, Burcu Gumuscu, Roland Brock, Wouter P. R. Verdurmen, Johan van der Vlag, Tom Nijenhuis   +8 more
doaj   +1 more source

High-resolution imaging of kidney vascular corrosion casts with nano-CT [PDF]

, 2010
A vascular corrosion cast of an entire mouse kidney was scanned with a modular multiresolution X-ray nanotomography system. Using an isotropic voxel pitch of 0.5 mu m, capillary systems such as the vasa recta, peritubular capillaries and glomeruli were ...
Czymmek, Kirk, Hossler, Fred, Pauwels, Elin, Van Hoorebeke, Luc, Van Loo, Denis, Wagner, Roger   +5 more
core   +1 more source

Injection of hybrid 3D spheroids composed of podocytes, mesenchymal stem cells, and vascular endothelial cells into the renal cortex improves kidney function and replenishes glomerular podocytes

Bioengineering & Translational Medicine, 2021
Podocytes are highly differentiated epithelial cells that are crucial for maintaining the glomerular filtration barrier in the kidney. Podocyte injury followed by depletion is the major cause of pathological progression of kidney diseases.
Wen‐Yu Yang, Li‐Chi Chen, Ya‐Ting Jhuang, Yu‐Jie Lin, Pei‐Yu Hung, Yi‐Ching Ko, Meng‐Yu Tsai, Yun‐Wei Lee, Li‐Wen Hsu, Chih‐Kuang Yeh, Hsiang‐Hao Hsu, Chieh‐Cheng Huang   +11 more
doaj   +1 more source

The ShGlomAssay Combines High-Throughput Drug Screening With Downstream Analyses and Reveals the Protective Role of Vitamin D3 and Calcipotriol on Podocytes

Frontiers in Cell and Developmental Biology, 2022
Chronic kidney disease (CKD) is a major public health burden affecting more than 500 million people worldwide. Podocytopathies are the main cause for the majority of CKD cases due to pathogenic morphological as well as molecular biological alterations of
Marie-Christin Ristov, Tim Lange, Nadine Artelt, Neetika Nath, Andreas W. Kuss, Jochen Gehrig, Jochen Gehrig, Maja Lindenmeyer, Clemens D. Cohen, Sheraz Gul, Karlhans Endlich, Uwe Völker, Nicole Endlich   +12 more
doaj   +1 more source

MicroRNAs and the glomerulus [PDF]

Experimental Cell Research, 2012
MicroRNAs (miRNAs) are short non-coding RNAs regulating gene expression at the post-transcriptional level by blocking translation or promoting cleavage of their target mRNAs. Increasing evidence shows that miRNAs play central roles in gene transcription, signal transduction and pathogenesis of human diseases.
Mitsuo, Kato, Jung Tak, Park, Rama, Natarajan   +2 more
openaire   +3 more sources