Results 41 to 50 of about 403,504 (246)

Control of Leukocyte Trafficking by Stress-Associated Hormones

Frontiers in Immunology, 2019
Leukocyte migration is a crucial process in both homeostatic and inflammatory conditions. The spatiotemporal distribution of immune cells is balanced between processes of cellular mobilization into the bloodstream, their adhesion to vascular beds and ...
Louise M. Ince, Jasmin Weber, Christoph Scheiermann, Christoph Scheiermann, Christoph Scheiermann   +4 more
doaj   +1 more source

Clinical efficacy of recombinant human thrombopoietin combined with glucocorticoids in the treatment of immune thrombocytopenia

Hematology, 2022
Objective: Herein, we aimed to determine the clinical efficacy of recombinant human thrombopoietin (rhTPO) combined with glucocorticoids for treating immune thrombocytopenia (ITP).Methods: Clinical data of 87 patients with ITP admitted to our hospital ...
Jing-xin Zhou, Ling Gao, Nan Hu, Zhi-Ling Yan, Chun-ying Tian, Jing Su, Ji-Jin Qi, Jun-shuai Yue, Wen-tong Ma   +8 more
doaj   +1 more source

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Banerji, Becker, Becker, Buetti, Cartwright, Chandler, Chen, Church, DeFranco, Gilbert, Gluecksohn-Waelsch, Gorman, Granner, Greengard, Hargrove, Hashimoto, Hochschild, Hynes, Karin, Karin, Killary, Maniatis, Maxam, Melton, Miksicek, Payvar, Pelham, Ptashne, Renkawitz, Ringold, Ruiz-Bravo, Scheidereit, Scherer, Schmid, Searle, Serfling, Sergeant, Singh, Slater, Yamamoto, Zaret, Zinn   +41 more
core   +1 more source

Glucocorticoids and resilience [PDF]

Hormones and Behavior, 2019
All organisms endure frequent challenges to homeostasis, or stressors, that require adaptation. Depending on the individual, the context, and the magnitude of stress, this active adaptation can lead to behavioral susceptibility or resilience. The latter is an under-appreciated consequence of stress, as the damaging effects of chronic stress and ...
Joanna L. Spencer-Segal, Joanna L. Spencer-Segal, Huda Akil   +2 more
openaire   +3 more sources

A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance [PDF]

, 2010
Background: Acquired resistance to glucocorticoids constitutes a major clinical challenge, often overlooked in the search for improved alternatives to classic steroids.
De Bosscher, Karolien, Dewint, Pieter, Elewaut, Dirk, Gossye, Valerie, Haegeman, Guy, Van Beneden, Katrien   +5 more
core   +2 more sources

Diagnosis and approach to glucocorticoid-induced adrenal insufficiency and glucocorticoid withdrawal syndrome

Journal of Education, Health and Sport
Introduction and purpose: Primary adrenal insufficiency can result from diseases affecting the adrenal glands, while secondary adrenal insufficiency is caused by suppression of the hypothalamic-pituitary-adrenal axis.
Aleksandra Kiełczewska, Grzegorz Szcześniak, Anna Kiełczewska   +2 more
doaj   +1 more source

Chronopharmacology of glucocorticoids

Advanced Drug Delivery Reviews, 2019
Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in homeostasis and preservation of normal organ function. Synthesis is regulated by the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is the primary glucocorticoid in humans.
Megerle L. Scherholz, Ioannis P. Androulakis, Naomi Schlesinger   +2 more
openaire   +4 more sources

Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]

, 2006
BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Ale Algra, Anne-Margriet Huisman, Ans C.M. Oostveen, Ben A.C. Dijkmans, Chris E.D. de Laet, de Nijs RN, Erik Buskens, George A.W. Bruyn, Johannes W.G. Jacobs, Johannes W.J. Bijlsma, Michel BA, Piet P.M.M. Geusens, Roland F.J. Laan, Ron N.J. de Nijs, Willem F. Lems   +14 more
core   +4 more sources

SIRT1: potential target in glucocorticoid-resistant diseases

Frontiers in Immunology
Glucocorticoid resistance is a challenging problem in clinical practice. Increasing glucocorticoid sensitivity and reducing resistance are important in the management of certain diseases.
Jun Xie, Siyi Che, Jiao Liu, Xiaoru Long
doaj   +1 more source

Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection

Pathogens, 2022
Background: Corneal infection of Colletotrichum gloeosporioides is uncommon and usually limited to the anterior stroma. However, we observed a case of corneal stromal perforation caused by this fungus under a compromised condition.
Kazuki Imai, Takayoshi Sumioka, Hiroki Iwanishi, Yukihisa Takada, Shin’ichi Murata, Ryuta Iwamoto, Yuka Okada, Shizuya Saika   +7 more
doaj   +1 more source