Results 41 to 50 of about 460,157 (392)

Omega-3 fatty acids reduce the negative effects of dexamethasone-induced physiological stress in laying hens by acting through the nutrient digestibility and gut morphometry

Poultry Science, 2021
In this study, the effects of omega-3 fatty acids on egg production, nutrients digestibility, eggs yolk lipid peroxidation, and intestinal morphology in laying hens under physiological stress were investigated.
Atefeh Berenjian, Seyed Davood Sharifi, Abdollah Mohammadi-Sangcheshmeh, Mohammad Reza Bakhtiarizadeh   +3 more
doaj  

Efficacy and Safety of Dupilumab in Glucocorticoid‐Dependent Severe Asthma

New England Journal of Medicine, 2018
BACKGROUND Dupilumab is a fully human anti–interleukin‐4 receptor α monoclonal antibody that blocks both interleukin‐4 and interleukin‐13 signaling. Its effectiveness in reducing oral glucocorticoid use in patients with severe asthma while maintaining ...
K. Rabe, Parameswaran Nair, G. Brusselle, J. Maspero, M. Castro, L. Sher, Hongjie Zhu, J. Hamilton, B. Swanson, A. Khan, J. Chao, H. Staudinger, G. Pirozzi, C. Antoni, N. Amin, M. Ruddy, B. Akinlade, N. Graham, N. Stahl, G. Yancopoulos, A. Teper   +20 more
semanticscholar   +1 more source

Glucocorticoids in pregnancy

Obstetric Medicine, 2019
The physiological changes that occur during pregnancy include altered regulation of the hypothalamo-pituitary-adrenal axis. The fetoplacental unit plays a major role in this, together with alteration of circulating cortisol-binding globulin levels, with a net effect to increase both total and free cortisol levels.
Riccardo Pofi, Riccardo Pofi, Jeremy W. Tomlinson   +2 more
openaire   +5 more sources

siRNA targeting Schlemm’s canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model

Molecular Therapy: Methods & Clinical Development, 2021
Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impairment.
Paul S. Cassidy, Ruth A. Kelly, Ester Reina-Torres, Joseph M. Sherwood, Marian M. Humphries, Anna-Sophia Kiang, G. Jane Farrar, Colm O’Brien, Matthew Campbell, W. Daniel Stamer, Darryl R. Overby, Pete Humphries, Jeffrey O’Callaghan   +12 more
doaj  

Benefits of glucocorticoids in non-ambulant boys/men with Duchenne muscular dystrophy: A multicentric longitudinal study using the Performance of Upper Limb test [PDF]

, 2015
The aim of this study was to establish the possible effect of glucocorticoid treatment on upper limb function in a cohort of 91 non-ambulant DMD boys and adults of age between 11 and 26 years.
Baranello, Giovanni, Barp, Andrea, Battini, Roberta, Bello, Luca, Berardinelli, Angela, Bertini, Enrico, Bianco, Flaviana, Bonfiglio, Serena, Bruno, Claudio, Carlesi, Adelina, Cavallaro, Filippo, D'Amico, Adele, D'Angelo, Grazia, De Sanctis, Roberto, Fanelli, Lavinia, Frosini, Silvia, Gardani, Alice, Gorni, Ksenija, Iotti, Elena, Lanzillotta, Valentina, Mazzone, Elena Stacy, Mercuri, Eugenio, Messina, Sonia, Mongini, Tiziana, Olivieri, Giorgia, Palermo, Concetta, Pane, Marika, Pegoraro, Elena, Petillo, Roberta, Pini, Antonella, Politano, Luisa, Rolle, Enrica, Scutifero, Marianna, Sframeli, Maria, Sivo, Serena, Sormani, Maria Pia, Viggiano, Emanuela, Vita, Gian Luca   +37 more
core   +3 more sources

Glucocorticoids and resilience [PDF]

Hormones and Behavior, 2019
All organisms endure frequent challenges to homeostasis, or stressors, that require adaptation. Depending on the individual, the context, and the magnitude of stress, this active adaptation can lead to behavioral susceptibility or resilience. The latter is an under-appreciated consequence of stress, as the damaging effects of chronic stress and ...
Joanna L. Spencer-Segal, Joanna L. Spencer-Segal, Huda Akil   +2 more
openaire   +3 more sources

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases [PDF]

, 2004
Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of ...
Atsuta J, Boner AL, Bridgman A, Callen J, Delescluse J, Dooms-Goossens AE, Dykes PJ, Falcoz C, Fisher DA, Goossens A, Harding SM, Hogger P, James M, Johnson M, Johnson M, Juhlin L, Katz HI, Korting HC, Lebwohl M, Li JT, Liu XQ, Llewellyn-Jones CG, Lucky AW, McKenzie AW, McLean HM, Nurnberger FG, Phillipps GH, Roberts DT, Spencer CM, Tharp MD, Venning VA, Wilkinson SM, Wolkerstorfer A, Young MMR   +33 more
core   +1 more source

Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. [PDF]

, 2016
Based on molecular mechanisms and physiologic data, a strong association has been established between dysregulated systemic inflammation and progression of acute respiratory distress syndrome (ARDS).
Meduri, Gianfranco Umberto, Schwingshackl, Andreas   +1 more
core   +1 more source

Influence of Implant Surface Topography on Primary Stability in a Standardized Osteoporosis Rabbit Model Study

Journal of Functional Biomaterials, 2015
Evaluating primary stability is important to predict the prognosis of dental implant treatment. Primary stability is decreased in a low bone density site such as osteoporosis.
Hiroshi Oue, Kazuya Doi, Yoshifumi Oki, Yusuke Makihara, Takayasu Kubo, Vittoria Perrotti, Adriano Piattelli, Yasumasa Akagawa, Kazuhiro Tsuga   +8 more
doaj   +1 more source

Extra-adrenal glucocorticoid biosynthesis: Implications for autoimmune and inflammatory disorders.

Genes and Immunity, 2020
Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone.
R. Slominski, R. Tuckey, P. Manna, A. Jetten, A. Postlethwaite, C. Raman, A. Slominski   +6 more
semanticscholar   +1 more source