Results 41 to 50 of about 443,164 (406)

Efficacy and Safety of Dupilumab in Glucocorticoid‐Dependent Severe Asthma

New England Journal of Medicine, 2018
BACKGROUND Dupilumab is a fully human anti–interleukin‐4 receptor α monoclonal antibody that blocks both interleukin‐4 and interleukin‐13 signaling. Its effectiveness in reducing oral glucocorticoid use in patients with severe asthma while maintaining ...
K. Rabe, Parameswaran Nair, G. Brusselle, J. Maspero, M. Castro, L. Sher, Hongjie Zhu, J. Hamilton, B. Swanson, A. Khan, J. Chao, H. Staudinger, G. Pirozzi, C. Antoni, N. Amin, M. Ruddy, B. Akinlade, N. Graham, N. Stahl, G. Yancopoulos, A. Teper   +20 more
semanticscholar   +1 more source

Glucocorticoids

, 2016
The most effective anti-inflammatory drugs used to treat patients with airways disease are topical glucocorticosteroids (GCs). These act on virtually all cells within the airway to suppress airway inflammation or prevent the recruitment of inflammatory cells into the airway.
Adcock, IM, Mumby, S
openaire   +4 more sources

Glucocorticoids and resilience [PDF]

Hormones and Behavior, 2019
All organisms endure frequent challenges to homeostasis, or stressors, that require adaptation. Depending on the individual, the context, and the magnitude of stress, this active adaptation can lead to behavioral susceptibility or resilience. The latter is an under-appreciated consequence of stress, as the damaging effects of chronic stress and ...
Joanna L. Spencer-Segal, Joanna L. Spencer-Segal, Huda Akil   +2 more
openaire   +3 more sources

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies [PDF]

, 2018
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL).
Beck, Ilse, Clarisse, Dorien, De Bosscher, Karolien, Offner, Fritz, Tavernier, Jan, Van Wesemael, Karlien   +5 more
core   +7 more sources

Omega-3 fatty acids reduce the negative effects of dexamethasone-induced physiological stress in laying hens by acting through the nutrient digestibility and gut morphometry

Poultry Science, 2021
In this study, the effects of omega-3 fatty acids on egg production, nutrients digestibility, eggs yolk lipid peroxidation, and intestinal morphology in laying hens under physiological stress were investigated.
Atefeh Berenjian, Seyed Davood Sharifi, Abdollah Mohammadi-Sangcheshmeh, Mohammad Reza Bakhtiarizadeh   +3 more
doaj  

Wnt Inhibitors and Bone Turnover Markers in Patients With Polymyalgia Rheumatica and Acute Effects of Glucocorticoid Treatment

Frontiers in Medicine, 2020
Background: In polymyalgia rheumatica (PMR), data on bone turnover markers (BTM), on Wnt inhibitors (Dkk-1, sclerostin) and their changes induced by glucocorticoids (GC) are lacking.
Angelo Fassio, Giovanni Adami, Luca Idolazzi, Alessandro Giollo, Ombretta Viapiana, Elisabetta Vantaggiato, Camilla Benini, Maurizio Rossini, Christian Dejaco, Christian Dejaco, Davide Gatti   +10 more
doaj   +1 more source

Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report

Frontiers in Medicine, 2022
Mucormycosis is a rare and invasive fungal infection with high mortality. Cases of invasive pulmonary mucormycosis that involve allergic reactions such as allergic bronchopulmonary mycosis are rarely reported.
Ruhui Zhang, Ge Jin, Yasheng Zhan, Lisha Shen, Yake Yao, Qiqi Gao, Qing Yang, Jianying Zhou, Hua Zhou   +8 more
doaj   +1 more source

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases [PDF]

, 2005
Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of ...
Atsuta J, Boner AL, Bridgman A, Callen J, Delescluse J, Dooms-Goossens AE, Dykes PJ, Falcoz C, Fisher DA, Goossens A, Harding SM, Hogger P, James M, Johnson M, Johnson M, Juhlin L, Katz HI, Korting HC, Lebwohl M, Li JT, Liu XQ, Llewellyn-Jones CG, Lucky AW, McKenzie AW, McLean HM, Nurnberger FG, Phillipps GH, Roberts DT, Spencer CM, Tharp MD, Venning VA, Wilkinson SM, Wolkerstorfer A, Young MMR   +33 more
core   +1 more source

Glucocorticoids in pregnancy

Obstetric Medicine, 2019
The physiological changes that occur during pregnancy include altered regulation of the hypothalamo-pituitary-adrenal axis. The fetoplacental unit plays a major role in this, together with alteration of circulating cortisol-binding globulin levels, with a net effect to increase both total and free cortisol levels.
Riccardo Pofi, Riccardo Pofi, Jeremy W. Tomlinson   +2 more
openaire   +5 more sources

siRNA targeting Schlemm’s canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model

Molecular Therapy: Methods & Clinical Development, 2021
Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impairment.
Paul S. Cassidy, Ruth A. Kelly, Ester Reina-Torres, Joseph M. Sherwood, Marian M. Humphries, Anna-Sophia Kiang, G. Jane Farrar, Colm O’Brien, Matthew Campbell, W. Daniel Stamer, Darryl R. Overby, Pete Humphries, Jeffrey O’Callaghan   +12 more
doaj