Results 11 to 20 of about 2,586,604 (408)
Glucocorticoid Receptor and Adipocyte Biology [PDF]
Nuclear Receptor Research, 2018 Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Rebecca A. Lee +2 more
semanticscholar +9 more sources
The Glucocorticoid Receptor in Cardiovascular Health and Disease
Cells, 2019 The glucocorticoid receptor is a member of the nuclear receptor family that controls many distinct gene networks, governing various aspects of development, metabolism, inflammation, and the stress response, as well as other key biological processes in ...
Bing Liu +3 more
doaj +2 more sources
Glucocorticoid receptor modulators.
Annales d'Endocrinologie, 2018 The glucocorticoid hormone cortisol acts throughout the body to support circadian processes and adaptation to stress. The glucocorticoid receptor is the target of cortisol and of synthetic glucocorticoids, which are used widely in the clinic. Both agonism and antagonism of the glucocorticoid receptor may be beneficial in disease, but given the wide ...
O. Meijer, L. Koorneef, Jan Kroon
semanticscholar +5 more sources
Glucocorticoid receptor signaling in the brain and its involvement in cognitive function [PDF]
Neural Regeneration ResearchThe hypothalamic–pituitary–adrenal axis regulates the secretion of glucocorticoids in response to environmental challenges. In the brain, a nuclear receptor transcription factor, the glucocorticoid receptor, is an important component of the hypothalamic ...
Chonglin Su +5 more
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Glucocorticoid receptors and depression. [PDF]
BMJ, 1986 The number of glucocorticoid receptor sites in lymphocytes was estimated and plasma cortisol concentrations measured in 17 depressed patients, 12 patients with chronic schizophrenia, and 31 healthy control subjects. The number of receptor sites was significantly lower in the depressed patients than in either the controls or the patients with chronic ...
Lawrence J. Whalley +5 more
openalex +5 more sources
Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]
Nature Communications, 2017 The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
G. Sorrentino +12 more
semanticscholar +5 more sources
Glucocorticoid Receptor Maintains Vasopressin Responses in Kidney Collecting Duct Cells
Frontiers in Physiology, 2022 Water permeability of the kidney collecting ducts is regulated in part by the amount of the molecular water channel protein aquaporin-2 (AQP2), whose expression, in turn, is regulated by the pituitary peptide hormone vasopressin.
Hsiu-Hui Yang +5 more
doaj +1 more source
Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
Nature Communications, 2021 Endothelial cells play a key role in the regulation of disease. Defective regulation of endothelial cell homeostasis may cause mesenchymal activation of other endothelial cells or neighboring cell types, and in both cases contributes to organ fibrosis ...
S. Srivastava +5 more
semanticscholar +1 more source
Frontiers in Physiology, 2021 Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho +4 more
doaj +1 more source
B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
Neurobiology of Stress, 2023 Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett +2 more
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