Results 151 to 160 of about 2,803 (180)

Glucosinolate hydrolysis and bioavailability of resulting isothiocyanates: Focus on glucoraphanin

Journal of Functional Foods, 2014
There is a growing interest in the health benefits of broccoli. Sulforaphane, the major bioactive component in broccoli, is an unstable isothiocyanate stored in the plant as glucoraphanin. Myrosinase enzymes release sulforaphane when the plant is crushed. Extraction during supplement formulation or heat processing can destroy myrosinase.
Donato Angelino, Elizabeth Jeffery
exaly   +5 more sources

Sulforaphane is Superior to Glucoraphanin in Modulating Carcinogen-Metabolising Enzymes in Hep G2 Cells

Asian Pacific Journal of Cancer Prevention, 2013
Glucoraphanin is the main glucosinolate found in broccoli and other cruciferous vegetables (Brassicaceae). The objective of the study was to evaluate whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolising enzyme systems in vitro.
Noramaliza M N, Ahmad Faizal Abdull Razis   +1 more
exaly   +5 more sources

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Glucoraphanin in Keimsaaten

Zeitschrift für Phytotherapie, 2023
ZusammenfassungAls eine vielversprechende Quelle für bioaktive pflanzliche Sekundärstoffe gelten Keimsprossen von Kreuzblütlerpflanzen (Familie: Brassicaceae). Vor allem das in Brokkolisprossen in höheren Konzentrationen vorkommende Glucoraphanin ist als bioaktiver Naturstoff von
Matthias Lechtenberg, Gerd Böhme, Andreas Hensel   +2 more
openaire   +1 more source

The effect of processing and cooking on glucoraphanin and sulforaphane in brassica vegetables

Food Chemistry, 2021
Brassica vegetables are widely consumed mostly after processing and cooking. These processing and cooking methods not only can affect the taste, texture, flavor and nutrients of these vegetables, but also influence the levels of some important bioactive compounds, such as glucosinolates (GLSs).
Jing, Sun, Yunfan, Wang, Xinyi, Pang, Shuhua, Tian, Qiaobin, Hu, Xiangfei, Li, Jie, Liu, Jing, Wang, Yingjian, Lu   +8 more
openaire   +2 more sources

Calcium affects glucoraphanin metabolism in broccoli sprouts under ZnSO4 stress

Food Chemistry, 2021
CaCl2, Ca2+ chelator (EGTA) and Ca2+ channel blocker (verapamil) were used to investigate mechanism of glucoraphanin metabolism in broccoli sprouts under ZnSO4 stress. CaCl2 treatment promoted sprout growth, reduced MDA (malonaldehyde) content and electrolyte leakage in sprouts under ZnSO4 stress.
Yinglian Zhu, Jun-Xia Xiao, Fengwu Wang   +2 more
exaly   +3 more sources

A total synthesis of ( R , S ) S -glucoraphanin

Tetrahedron, 2013
Abstract A total synthesis of (R,S)S-glucoraphanin (GRP) has been completed by a novel, simple and convenient method in high overall yield (17% over seven steps). The study describes a method for the synthesis of natural and unnatural (methylsulfinyl)alkyl glucosinolates (GLs) and also opens useful pathways to synthesize GRP as well as other sulfinyl
Quan V Võ, Simone Rochfort
exaly   +2 more sources

The Metabolic Fate of Purified Glucoraphanin in F344 Rats

Journal of Agricultural and Food Chemistry, 2007
Dietary broccoli is commonly eaten cooked, exposing individuals to intact glucoraphanin rather than to its hydrolysis product, the anticarcinogenic isothiocyanate sulforaphane, since cooking destroys the hydrolyzing enzyme myrosinase. There is little information on the absorption and metabolism of glucoraphanin, due partly to the lack of purified ...
Radha M, Bheemreddy, Elizabeth H, Jeffery   +1 more
openaire   +2 more sources

Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin

Food and Chemical Toxicology, 2008
The anti-carcinogenic effects of broccoli have been attributed to sulforaphane, the hydrolysis product of glucoraphanin (GRP). Here we determined if purified GRP, in the absence of the plant-derived hydrolyzing enzyme myrosinase, could affect pulmonary and hepatic ethoxyresorufin O-deethylase (EROD) and/or NAD(P)H-quinone oxidoreductase 1 (NQO1 ...
R-H, Lai, A-S, Keck, M A, Wallig, L G, West, E H, Jeffery   +4 more
openaire   +2 more sources

Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption

Food & Function, 2010
In the absence of the plant enzyme myrosinase, such as in cooked broccoli, glucoraphanin is considered to be hydrolyzed by bacteria in the lower gut to produce the bioactive isothiocyanate sulforaphane. Simulated digestion using US Pharmacopeia methods caused no loss of glucoraphanin, confirming that glucoraphanin is not destroyed by digestive enzymes ...
Ren-Hau, Lai, Michael J, Miller, Elizabeth, Jeffery   +2 more
openaire   +2 more sources

Formation of glucoraphanin by chemoselective oxidation of natural glucoerucin: A chemoenzymatic route to sulforaphane

Bioorganic & Medicinal Chemistry Letters, 1999
A new semi-synthetic way to produce glucoraphanin (2), the bio-precursor of the potential anticarcinogen sulforaphane (3), has been developed. Starting from glucoerucin (1), isolated from ripe seeds of Eruca sativa, glucoraphanin was obtained through chemoselective oxidation.
R, Iori, R, Bernardi, D, Gueyrard, P, Rollin, S, Palmieri   +4 more
openaire   +2 more sources