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Glucose-dependent insulinotropic polypeptide (GIP) [PDF]

Molecular Metabolism
Background: Glucose-dependent insulinotropic polypeptide (GIP) was the first incretin identified and plays an essential role in the maintenance of glucose tolerance in healthy humans.
Timo D. Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L. Birkenfeld, Jonathan E. Campbell, Matthew P. Coghlan, David D'Alessio, Carolyn F. Deacon, Stefano DelPrato, Jonathan D. Douros, Daniel J. Drucker, Natalie S. Figueredo Burgos, Peter R. Flatt, Brian Finan, Ruth E. Gimeno, Fiona M. Gribble, Matthew R. Hayes, Christian Hölscher, Jens J. Holst, Patrick J. Knerr, Filip K. Knop, Christine M. Kusminski, Arkadiusz Liskiewicz, Guillaume Mabilleau, Stephanie A. Mowery, Michael A. Nauck, Aaron Novikoff, Frank Reimann, Anna G. Roberts, Mette M. Rosenkilde, Ricardo J. Samms, Philip E. Scherer, Randy J. Seeley, Kyle W. Sloop, Christian Wolfrum, Denise Wootten, Richard D. DiMarchi, Matthias H. Tschöp   +38 more
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Roles of glucose‐dependent insulinotropic polypeptide in diet‐induced obesity [PDF]

Journal of Diabetes Investigation, 2022
Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are incretins that play an important role in glucose metabolism, by increasing glucose‐induced insulin secretion from pancreatic β‐cells and help regulate bodyweight ...
Yusuke Seino, Yuji Yamazaki
doaj   +4 more sources

Glucose-dependent insulinotropic polypeptide stimulates post-absorptive lipid secretion in the intestine [PDF]

Frontiers in Physiology
It is increasingly recognized that the intestine can retain a portion of dietary fats for secretion during the post-absorptive state, which has strong implications in metabolic diseases.
Rong Wang, Muhammad Saad Abdullah Khan, Kundanika Mukherjee, Murooj Ghanem, Changting Xiao   +4 more
doaj   +2 more sources

Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women [PDF]

Endocrine Connections
Background/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in ...
Isidora Salvatierra, Javier Parada, Rodrigo Cataldo, José Eduardo Galgani, Gigliola Alberti, Idoia Labayen, José L Santos   +6 more
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Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 secretion in humans: Characteristics and regulation [PDF]

Journal of Diabetes Investigation, 2023
Aims/Introduction Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are important incretin hormones. They are released from the gut after meal ingestion and potentiate glucose‐stimulated insulin secretion.
Wathik Alsalim, Ola Lindgren, Bo Ahrén
doaj   +2 more sources

Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice [PDF]

JCI Insight
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are gut-derived peptide hormones that potentiate glucose-dependent insulin secretion.
Rola Hammoud, Kiran Deep Kaur, Jacqueline A. Koehler, Laurie L. Baggio, Chi Kin Wong, Katie E. Advani, Bernardo Yusta, Irina Efimova, Fiona M. Gribble, Frank Reimann, Sigal Fishman, Chen Varol, Daniel J. Drucker   +12 more
doaj   +2 more sources

Glucose-Dependent Insulinotropic Polypeptide Plasma Level Influences the Effect of n-3 PUFA Supplementation [PDF]

Diagnostics, 2022
Elevated glucose-dependent insulinotropic peptide (GIP) levels in obesity may predict the metabolic benefits of n-3 PUFA supplementation. This placebo-controlled trial aimed to analyze fasting and postprandial GIP response to 3-month n-3 PUFA ...
Joanna Goralska, Urszula Razny, Philip C. Calder, Anna Gruca, Caroline E. Childs, Piotr Zabielski, Aldona Dembinska-Kiec, Maciej Banach, Bogdan Solnica, Malgorzata Malczewska-Malec   +9 more
doaj   +2 more sources

The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury [PDF]

Cardiovascular Diabetology, 2022
Background The gut incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by enteroendocrine cells following food intake leading to insulin secretion and glucose lowering.
Florian Kahles, Matthias Rau, Martin Reugels, Ann C. Foldenauer, Robert W. Mertens, Maria C. Arrivas, Jörg Schröder, Paul Idel, Julia Moellmann, Emiel P. C. van der Vorst, Nikolaus Marx, Michael Lehrke   +11 more
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Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding [PDF]

JCI Insight, 2023
Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics’ ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understood. We explored
Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O’Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J. Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann   +20 more
doaj   +2 more sources

Out of stock: A brief clinical reference for rough equivalency of glucagon‐like peptide‐1 (GLP‐1) ± glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists for A1c and weight reduction in people with type 2 diabetes [PDF]

Journal of Diabetes
Highlights Despite the common practice of switching patients from one medicine to another—to improve efficacy, safety, or tolerability—guidance on how to do so is uncommon.
Leigh Perreault, Bryan C. Bergman
doaj   +2 more sources