Results 91 to 100 of about 1,256,400 (271)
Phytotherapy Research, EarlyView.Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández +5 more
wiley +1 more source
TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum
Insect Science, EarlyView.RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li +8 more
wiley +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Microbial Cell Factories, 2017 Efficient xylose utilization is one of the most important pre-requisites for developing an economic microbial conversion process of terrestrial lignocellulosic biomass into biofuels and biochemicals.
Suryang Kwak, Yong-Su Jin
doaj +1 more source
Effect of Radical Anions on the Inactivation of Glucose Isomerase
Agricultural and Biological Chemistry, 1983 The inactivation of glucose isomerase by radiolytically generated radical anions was in-vestigated. In a pure solution of the enzyme at pH 7.0, Br- had a pronounced radiosensitizing action whereas CNS– had a protective action. The Br- did not sensitize the inactivation of the enzyme irradiated at higher pH levels.
KUME, Tamikazu, TAKEHISA, Masaaki
openaire +2 more sources
Room-Temperature Structure of Xylitol-Bound Glucose Isomerase by Serial Crystallography: Xylitol Binding in the M1 Site Induces Release of Metal Bound in the M2 Site. [PDF]
Int J Mol Sci, 2021 Nam KH.
europepmc +1 more source
Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer
Cancer Science, EarlyView.Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo +6 more
wiley +1 more source
Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury
Cellular Physiology and Biochemistry, 2018 Background/Aims: Peptidyl-prolyl cis-trans isomerase FKBP25 is a member of the FK506-binding proteins family which has peptidyl-prolyl cis/trans isomerase domain. The biological function and pathophysiologic role of FKBP25 remain elusive.
Quan Jiang +9 more
doaj +1 more source
Polymorphic Protein Crystal Growth: Influence of Hydration and Ions in Glucose Isomerase
Crystal Growth & Design, 2013 Crystal polymorphs of glucose isomerase were examined to characterize the properties and to quantify the energetics of protein crystal growth. Transitions of polymorph stability were measured in poly(ethylene glycol)/NaCl solutions, and one transition ...
C. Gillespie, D. Asthagiri, A. Lenhoff
semanticscholar +1 more source
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source