Results 221 to 230 of about 77,800,290 (253)

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Double autoimmune endocrinopathies: concurrent presentation of latent autoimmune diabetes in adults and Graves disease. [PDF]

JCEM Case Rep
Tun Z, Baugh M, Ngo EM.
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Pancreatic islet α cell function and proliferation require the arginine transporter SLC7A2. [PDF]

J Clin Invest
Spears E, Stanley JE, Shou M, Yin L, Li X, Dai C, Bradley A, Sellick K, Poffenberger G, Coate KC, Shrestha S, Schornack AMR, Shepard T, Wimalarathne M, Jenkins R, Sloop KW, Wilson KT, Attie AD, Keller MP, Chen W, Powers AC, Dean ED.   +21 more
europepmc   +1 more source

Myeloid-Derived Growth Factor Alleviates Diabetic Non-Alcoholic Fatty Liver Disease by Up-Regulating ABCA1 and ABCG1 Expression via the AMPK/PPARγ/LXRα Pathway. [PDF]

J Cell Mol Med
Chen Z, Meng B, Wang B, Ding Y.
europepmc   +1 more source

Sodium-Glucose Cotransporter 2-Mediated Glucose Uptake Contributes to Glycogen Accumulation in Clear Cell Renal Cell Carcinoma: Implications for Clear Cell Morphology and Potential Therapeutic Relevance. [PDF]

Int J Mol Sci
Nagata Y, Tomisaki I, Matsukawa T, Quynh NT, Tsubonuma Y, Sugita Y, Nawata A, Kokubu K, Baba R, Morimoto H, Ogawa K, Wada K, Fujimoto N.   +12 more
europepmc   +1 more source

SGLT2 versus DPP-4 inhibitors in type 2 diabetes: a meta-analysis of outcomes. [PDF]

Front Endocrinol (Lausanne)
Fang X, Li R, Liu S, Zou X, Zhong Y, Yang Y.   +5 more
europepmc   +1 more source

Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis. [PDF]

J Diabetes Investig
Ashok D, Manjrekar PA, Shetty BC, Sailet SS.   +3 more
europepmc   +1 more source

An inositol receptor Itr4 coordinates carbon catabolite regulation and virulence in Cryptococcus neoformans. [PDF]

PLoS Biol
Wang Y, Tancer RJ, Wear M, Jackson KM, Zhang Y, Li K, Wang J, Gao YG, Nielsen K, Casadevall A, Xue C.   +10 more
europepmc   +1 more source