Results 1 to 10 of about 12,664 (118)
Discovery of a Flexible Triazolylbutanoic Acid as a Highly Potent Uric Acid Transporter 1 (URAT1) Inhibitor [PDF]
Molecules, 2016 In order to systematically explore and understand the structure–activity relationship (SAR) of a lesinurad-based hit (1c) derived from the replacement of the S atom in lesinurad with CH2, 18 compounds (1a–1r) were designed, synthesized and subjected to ...
He Tian +10 more
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Probiotic potential of Lactiplantibacillus plantarum LBK from Koumiss in reducing hyperuricemia through gut microbiota modulation [PDF]
Frontiers in MicrobiologyHyperuricemia, a metabolic disorder resulting from purine metabolic dysfunction, poses a significant threat to public health. Probiotics, in particular lactic acid bacteria, have the potential to exert therapeutic benefits in the treatment of some ...
Panpan Zhao +32 more
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Journal of Ginseng Research, 2021 Background: Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders.
Yoon-Young Sung +2 more
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Marine Drugs, 2021 This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS ...
Yu Zhang +8 more
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Frontiers in Pharmacology, 2023 Hesperetin is a natural flavonoid with many biological activities. In view of hyperuricemia treatment, the effects of hesperetin in vivo and in vitro, and the underlying mechanisms, were explored.
Meng-Fei An +21 more
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Plants, 2021 Hyperuricemia, abnormally excess accumulation of uric acid, is caused by an imbalance between the production and excretion of uric acid and is a major cause of gout. We compared the effects of extracts from Chrysanthemum indicum L.
Ok-Kyung Kim +4 more
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Uric acid induces renal inflammation via activating tubular NF-κB signaling pathway. [PDF]
PLoS ONE, 2012 Inflammation is a pathologic feature of hyperuricemia in clinical settings. However, the underlying mechanism remains unknown. Here, infiltration of T cells and macrophages were significantly increased in hyperuricemia mice kidneys.
Yang Zhou +7 more
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Frontiers in Bioscience-Landmark, 2023 Background: Disorders of purine metabolism are the main cause of hyperuricemia. Current drugs for the treatment of hyperuricemia usually cause a degree of cardiovascular damage.
Zheng-Long Li, Shu-Min Wang, Huan Wang
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Biomolecules, 2020 The relationship of uric acid with macrophages has not been fully elucidated. We investigated the effect of uric acid on the proinflammatory ability of human macrophages and then examined the possible molecular mechanism involved. Primary human monocytes
Camilo P. Martínez-Reyes +8 more
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Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice
Frontiers in Pharmacology, 2019 Background:Eurycoma longifolia is a tropical medicinal plant belonging to Simaroubaceae distributed in South East Asia. The stems are traditionally used for the treatment of sexual insufficiency, fever, hypertension, and malaria.
Ruixia Bao +8 more
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