Results 21 to 30 of about 114,454,660 (263)

Morin Improves Urate Excretion and Kidney Function through Regulation of Renal Organic Ion Transporters in Hyperuricemic Mice

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. Morin (3,5,7,2′,4′-pentahydroxyflavone), a plant-derived flavonoid, has beneficial effects in animals with various diseases including hyperuricemia and renal dysfunction.
Cai-Ping Wang, Xing Wang, Xian Zhang, Yun-Wei Shi, Lei Liu, Ling-Dong Kong   +5 more
doaj   +1 more source

Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway

Antioxidants, 2021
Hyperuricemia is the main cause of gout and involved in the occurrence of many other diseases such as hyperlipidemia and hypertension correlated with metabolic disorders.
Yi-Hsien Chang, Yi-Fen Chiang, Hsin-Yuan Chen, Yun-Ju Huang, Kai-Lee Wang, Yong-Han Hong, Mohamed Ali, Tzong-Ming Shieh, Shih-Min Hsia   +8 more
doaj   +1 more source

Reproductive factors and serum uric acid levels in females from the general population: the KORA F4 study. [PDF]

, 2012
Hyperuricemia is associated with an increased risk of metabolic and cardiovascular diseases. There are pronounced sex differences in the levels of uric acid.
Döring, Angela, Thorand, Barbara, Petra Belcredi, Belcredi Petra, Döring, A., Margit Heier, Stöckl Doris, Thorand Barbara, Belcredi, P., Meisinger, Christa, Stöckl, Doris, Heier Margit, Meisinger Christa, Döring Angela, Stöckl, D., Christa Meisinger, Heier, M., Barbara Thorand, Thorand, B., Doris Stöckl, Angela Döring, Heier, Margit, Belcredi, Petra, Meisinger, C.   +23 more
core   +2 more sources

Placental Uric Acid Transport System: Glucose Transporter 9 (SLC2A9) [PDF]

, 2014
Placental Uric Acid Transport System: Glucose Transporter 9 (SLC2A9). INTRODUCTION: Pre-eclampsia, a pregnancy-specific disease, contributes substantially to perinatal morbidity and mortality of both the mother and her child.
Baumann, Marc Ulrich, Lüscher, Benjamin, Reymond, Jean-Louis, Hediger, Matthias, Jeanneret, Céline, Huang, Xiao, Albrecht, Christiane, Marini, Camilla, Surbek, Daniel, Clemençon, Benjamin, Sager, Ruth   +10 more
core   +2 more sources

Mechanism of Action of Limosilactobacillus fermentum FOSU-YHD19 in Alleviating Hyperuricemia [PDF]

Shipin Kexue
Objective: To investigate the mechanism underlying the uric acid-lowering effect of Limosilactobacillus fermentum FOSU-YHD19 (L. fermentum YHD19) at the cellular level. Methods: A hyperuricemic cell model was established using HK-2 cells.
HUANG Jiayi, LU Yunhui, HUANG Fang, WU Weitong, WANG Langhong, XIONG Jie, HUANG Yanyan
doaj   +1 more source

Pharmacological Basis for Use of a Novel Compound in Hyperuricemia: Anti-Hyperuricemic and Anti-Inflammatory Effects

Frontiers in Pharmacology, 2021
Background: The prevalence of hyperuricemia is considered high worldwide. Hyperuricemia occurs due to decreased excretion of uric acid, increased synthesis of uric acid, or a combination of both mechanisms. There is growing evidence that hyperuricemia is
Lei Zhao, Yihang Li, Yihang Li, Dahong Yao, Dahong Yao, Ran Sun, Shifang Liu, Xi Chen, Xi Chen, Congcong Lin, Jian Huang, Jinhui Wang, Guang Li, Guang Li   +13 more
doaj   +1 more source

Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.

PLoS ONE, 2019
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day
Kei Nishizawa, Noriaki Yoda, Fumi Morokado, Hisakazu Komori, Takeo Nakanishi, Ikumi Tamai   +5 more
doaj   +1 more source

Genistein ameliorates hyperuricemia-associated nephropathy in hyperuricemic mice

Food and Agricultural Immunology, 2021
Hyperuricemia is a metabolic disease caused by excessive production of uric acid (UA), which can cause gout, hypertension, hyperlipidemia and other diseases.
Bi Wei-Yun, Zhu Cailin
doaj   +1 more source

Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor. [PDF]

Molecules, 2018
In order to systematically explore and better understand the structure-activity relationship (SAR) of a diarylmethane backbone in the design of potent uric acid transporter 1 (URAT1) inhibitors, 33 compounds (1a–1x and 1ha–1hi) were designed and synthesized, and their in vitro URAT1 inhibitory activities (IC50) were determined.
Cai W, Wu J, Liu W, Xie Y, Liu Y, Zhang S, Xu W, Tang L, Wang J, Zhao G.   +9 more
europepmc   +4 more sources

Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2 [PDF]

American Journal of Physiology-Renal Physiology, 2017
Accumulating data indicate that renal uric acid (UA) handling is altered in diabetes and by hypoglycemic agents. In addition, hyperinsulinemia is associated with hyperuricemia and hypouricosuria. However, the underlying mechanisms remain unclear. In this study, we aimed to investigate how diabetes and hypoglycemic agents alter the levels of renal urate
Daigo, Toyoki, Shigeru, Shibata, Emiko, Kuribayashi-Okuma, Ning, Xu, Kenichi, Ishizawa, Makoto, Hosoyamada, Shunya, Uchida   +6 more
openaire   +2 more sources