Results 31 to 40 of about 114,454,660 (263)

Fructus Gardenia Extract Ameliorates Oxonate-Induced Hyperuricemia with Renal Dysfunction in Mice by Regulating Organic Ion Transporters and mOIT3

Molecules, 2013
The potent anti-hyperuricemia activities of Fructus Gardenia Extract (FGE) have been well reported. The aim of this study was to evaluate the uricosuric and nephro-protective effects of FGE and explore its possible mechanisms of action in oxonate-induced
Hui Ji, Lin-Lin Wei, Ming-Xing Miao, Jing Ji, Ji-Xiao Zhu, Qing-Hua Hu   +5 more
doaj   +1 more source

Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study

BMC Pharmacology and Toxicology, 2020
Background Hyperuricemia is an abnormal increase in uric acid levels in the blood. It is the cause of gout that manifested by inflammatory arthritis and painful disable.
Youssef Saeed Alghamdi, Mohamed Mohamed Soliman, Mohamed Abdo Nassan   +2 more
doaj   +1 more source

A novel strain of Levilactobacillus brevis PDD-5 isolated from salty vegetables has beneficial effects on hyperuricemia through anti-inflammation and improvement of kidney damage

Food Science and Human Wellness
Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism, resulting in abnormally high serum uric acid. In this study, a novel Levilactobacillus brevis PDD-5 isolated from salty vegetables was verified with the function of alleviating ...
Jue Xu, Maolin Tu, Xiankang Fan, Yuxing Guo, Tao Zhang, Xiaoqun Zeng, Zhendong Cai, Zhen Wu, Daodong Pan   +8 more
doaj   +1 more source

Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Zurampic is a US FDA approved drug for treatment of gout. However, the influence of Zurampic on pancreatic β-cells remains unclear. The study aimed to evaluate the effects of Zurampic on high uric acid-induced damage of pancreatic β ...
Ying Xin, Kun Wang, Zhaotong Jia, Tao Xu, Qiang Xu, Chao Zhang, Jia Liu, Rui Chen, Zhongcai Du, Jianjing Sun   +9 more
doaj   +1 more source

A role for uric acid and the nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast [PDF]

, 2013
Women with antiphospholipid syndrome (APS) are at risk of recurrent pregnancy loss and obstetrical disorders, such as preeclampsia and intrauterine growth restriction (IUGR).
Vikki M Abrahams, Kavathas, Paula B., Melissa J Mulla, Crina M Boeras, Mulla, Melissa J., Paula B Kavathas, Jan J Brosens, Brosens, Jan J., Boeras, Crina M., Larry W Chamley, Jane E Salmon, Abrahams, Vikki M., Salmon, Jane E., Chamley, Larry W., Boeras Crina M., Chamley Larry W., Abrahams Vikki M., Mulla Melissa J., Salmon Jane E., Brosens Jan J., Kavathas Paula B.   +20 more
core   +2 more sources

Fucoidan alleviates the hepatorenal syndrome through inhibition organic solute transporter α/β to reduce bile acids reabsorption

Current Research in Pharmacology and Drug Discovery, 2023
The high levels of bile acids are a critical factor in hepatorenal syndrome. Organic solute transporter α/β (Ostα/β) participate in bile acids reabsorption in the kidney.
Xiaojuan Zhao, Ting Yang, Jiayan Zhou, Yanli Chen, Qian Shen, Jiankang Zhang, Qianqian Qiu   +6 more
doaj   +1 more source

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]

, 2008
<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Lees, K.R., Walters, M.R., Weir, C.J., Dawson, J., Muir, S.W., Sattar, N., Harrow, C.   +6 more
core   +1 more source

Molecular mechanistic insight into the anti-hyperuricemic effect of Eucommia ulmoides in mice and rats

Pharmaceutical Biology, 2019
Context: Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia.
Cong Fang, Lanying Chen, Mingzhen He, Yingying Luo, Mengjing Zhou, Ni Zhang, Jinfeng Yuan, Huiling Wang, Yongyan Xie   +8 more
doaj   +1 more source

Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice

Acta Pharmaceutica Sinica B, 2018
A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase (XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the ...
Zhizhen Qin, Shoubao Wang, Yihuang Lin, Ying Zhao, Shengqian Yang, Junke Song, Tao Xie, Jinlong Tian, Song Wu, Guanhua Du   +9 more
doaj   +1 more source

Phytochemical, Pharmacological And Pharmacokinetic Studies Of Phyllanthus Niruri Linn Lignans As Potential Antihyperuricemic Agents [QK861. V694 2008 f rb]. [PDF]

, 2008
Ekstrak metanol dari daun Phyllanthus niruri L. menunjukkan aktiviti antihiperurisemik oral yang bergantungan dos di dalam tikus hiperurisemia yang diaruh dengan kalium oksonat dan asid urik. The methanol extract from the leaves of Phyllanthus niruri
Murugaiyah, Vikneswaran
core   +1 more source