Results 11 to 20 of about 114,454,660 (263)

Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies [PDF]

Drug Design, Development and Therapy, 2012
Michael F Wempe,1 Janet W Lightner,2 Bettina Miller,1 Timothy J Iwen,1 Peter J Rice,1 Shin Wakui,3 Naohiko Anzai,4 Promsuk Jutabha,4 Hitoshi Endou51Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Anschutz Medical
Wempe MF, Lightner JW, Miller B, Iwen TJ, Rice PJ, Wakui S, Anzai N, Jutabha P, Endou H   +8 more
doaj   +9 more sources

Developing Potent Human Uric Acid Transporter 1 (hURAT1) Inhibitors [PDF]

Journal of Medicinal Chemistry, 2011
The kidneys are a vital organ in the human body. They serve several purposes including homeostatic functions such as regulating extracellular fluid volume and maintaining acid-base and electrolyte balance and are essential regarding the excretion of metabolic waste.
Wempe, Michael F., Jutabha, Promsuk, Quade, Bettina, Iwen, Timothy J., Frick, Morin M., Ross, Ian R., Rice, Peter J., Anzai, Naohiko, Endou, Hitoshi   +8 more
openaire   +4 more sources

Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1 [PDF]

ACS Omega, 2020
Abstract Background: Human urate transporter 1 (hURAT1) is the most pivotal therapeutic target for treating hyperuricemia. However, the molecular interactions between uric acid and URAT1 are still unknown due to lack of structural details.
Ze’an Zhao, Yu Jiang, Lu Li, Yanyu Chen, Yongmei Li, Qunsheng Lan, Ting Wu, Cuiting Lin, Ying Cao, Kutty Selva Nandakumar, Pingzheng Zhou, Yuanxin Tian, Jianxin Pang   +12 more
openaire   +6 more sources

Virtual screening and activity evaluation of human uric acid transporter 1 (hURAT1) inhibitors. [PDF]

RSC Adv, 2023
Alphafold2 was used to predict URAT1 protein structure, then the docking sites were identified, and three hit compounds were obtained through virtual screening and bioactivity verification.
Yang Y, Hu Y, Yao F, Yang J, Ge L, Wang P, Xu X.   +6 more
europepmc   +3 more sources

Impact of Renal Impairment on the Pharmacodynamic and Pharmacokinetic Profiles of Epaminurad, a Novel Uric Acid Transporter 1 Inhibitor. [PDF]

Clin Transl Sci
ABSTRACTEpaminurad, a novel uricosuric agent, exhibits potent inhibitory activity against the human uric acid transporter. This study aimed to investigate the effects of renal function and food intake on the pharmacokinetic, pharmacodynamic, and safety characteristics of 9 mg epaminurad.
Park SY, Hwang JG, Cho SK, Park MK.
europepmc   +4 more sources

Mutation in Transmembrane Domain 8 of Human Urate Transporter 1 Disrupts Uric Acid Recognition and Transport

ACS Omega, 2022
Human urate transporter 1 (hURAT1) is the most pivotal therapeutic target for hyperuricemia. Due to a lack of crystal structure information, the atomic structure of URAT1 is not clearly understood. In this study, a multiple sequence alignment was performed, and K393, a positively charged residue in transmembrane domain (TMD) 8, was observed to be ...
Qunsheng Lan, Ze’an Zhao, Hui Liao, Fengxin Zheng, Yongjun Chen, Ting Wu, Yuanxin Tian, Jianxin Pang   +7 more
openaire   +2 more sources

Sodium-Hydrogen Exchanger Regulatory Factor-1 Interacts with Mouse Urate Transporter 1 to Regulate Renal Proximal Tubule Uric Acid Transport [PDF]

Journal of the American Society of Nephrology, 2007
Sodium-hydrogen exchanger regulatory factor-1-deficient (NHERF-1(-/-)) mice demonstrate increases in the urinary excretion of phosphate, calcium, and uric acid associated with interstitial deposition of calcium in the papilla of the kidney. These studies examine the role of NHERF-1 in the tubular reabsorption of uric acid and regulation of mouse urate ...
Rochelle, Cunningham, Marc, Brazie, Srilatha, Kanumuru, Xiaofei, E, Rajat, Biswas, Fengying, Wang, Deborah, Steplock, James B, Wade, Naohiko, Anzai, Hitoshi, Endou, Shirish, Shenolikar, Edward J, Weinman   +11 more
openaire   +2 more sources

Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population [PDF]

Arthritis & Rheumatism, 2005
AbstractObjectiveHuman urate transporter 1 (hURAT1) is a member of the organic anion transporter family (SLC22A12) that mainly regulates tubular urate reabsorption. Loss‐of‐function mutations result in idiopathic hypouricemia. The present case–control study was designed to analyze whether hURAT1 might also be a candidate gene for hyperuricemia with ...
Juergen, Graessler, Anett, Graessler, Susette, Unger, Steffi, Kopprasch, Anne-Kathrin, Tausche, Eberhard, Kuhlisch, Hans-Egbert, Schroeder   +6 more
openaire   +2 more sources

SLC2A9 is a high-capacity urate transporter in humans [PDF]

, 2008
Background Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have
Doblado M, Kumari, Meena, Charchar, Fadi J, Samani, NJ, Elliott Paul, Kooner J, M. Marmot (7611368), Eyheramendy S, Dobson Richard J, Marmot, Michael, Connell, JM, Philip Howard, Caulfield, Mark J., J. Chambers (3846385), Connell John M, Munroe, Patricia B, John Chambers, Marmot Michael, Dobson, RJ, Charchar Fadi J, Doblado, M, Kumari, M, Morris Brown, Dobson RJ, Elliott, Paul, Gudrun Veldre, R. J. Dobson (7602557), Caulfield MJ, Iacone, Roberto, Laan, Maris, Lathrop, G. Mark, A. Dominiczak (7611551), Kooner, Jaspal, P. Strazzullo (7611365), Farrall Martin, Viigimaa Margus, Brown, M, Samani, Nilesh J., Francesco P Cappuccio, Lann, Maris, P. Howard (7611350), Nilesh J. Samani (7579793), Farrall, M, K. H. Moley (7611569), Newhouse, Stephen J, Munroe PB, Veldre, Gudrun, Wallace Chris, Evans, S, Chambers, John, Howard P, Martin Farrall, Deb O'Neill, Witkowska K, Newhouse, SJ, M. Laan (7602659), Maris Laan, Charchar FJ, Munroe Patricia B, M. Viigimaa (7602620), Cheeseman C., Dominiczak A, M. Doblado (7611566), Evans Sarah, Onipinla A, Shaw-Hawkins Sue, Lathrop GM, Evans, Sarah, Iacone Roberto, Marmot, M, C. Wallace (7602467), Munroe, PB, Witkowska, K, Wallace, C, M. Farrall (6522599), Moley, KH, Charchar, Fadi J., Brunner E, Eric Brunner, Chris Wallace, Brunner Eric, G. M. Lathrop (7611353), O'Neill, D, Dobson, Richard J., G Mark Lathrop, Richard J Dobson, F. J. Charchar (7591784), Howard Philip, Cappuccio FP, Cappuccio, Francesco, Evans S, E. Brunner (7611371), Lathrop, GM, S. Shaw-Hawkins (7602380), Org Elin, Chambers John, Moley, Kelle Harbert, F. P. Cappuccio (7611356), Wallace, Chris, Connell, J. M. C., Cheeseman, Chris, Sue Shaw-Hawkins, Stephen J Newhouse, Dobson, Richard, Samani NJ, Kelle H Moley, Patricia B Munroe, Howard, P, Wallace C, Cappuccio Francesco P, Veldre Gudrun, Caulfield Mark J, Manuel Doblado, Moley Kelle H, Elin Org, Viigimaa, M, S. J. Newhouse (7602371), Onipinla, Abiodun, Michael Marmot, Elliot, Paul, Dominiczak, A, Veldre G, R. Iacone (7611362), Abiodun Onipinla, Mark J Caulfield, Sarah Evans, Marmot M, Cheeseman Chris, Kooner, J, Brown Morris, J. Kooner (7609340), Laan, M, Moley, Kelle H, Witkowska Kate, Moley, Kelle H., C. Ji (7611359), Shaw Hawkins, Sue, Kumari Meena, P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Pasquale Strazzullo, Laan M, D. O'Neill (7611560), Brown, M. J. (Morris Jonathan), Shaw-Hawkins, Sue, Chris Cheeseman, Samani, Nilesh J, Strazzullo, P, Dobson, Richard; id_orcid, Cappuccio, Francesco P., K. Witkowska (7611563), Munroe, Patricia B., Cappucio, Francesco P., Charchar, FJ, Brunner, Eric, Newhouse SJ, Witkowska, Kate, Kate Witkowska, O'Neill, Deb, Moley KH, Elliott, P, Org, E, Lathrop G. Mark, Paul Elliott, E. Org (7602644), O'Neill Deb, Doblado Manuel, Caulfield, Mark, Marmot, Michael G., John M Connell, Onipinla Abiodun, Caulfield, MJ, Org E, J. M. Connell (7602551), Cappuccio, FP, Newhouse, Stephen, Onipinla, A, Susana Eyheramendy, Newhouse, Stephen J., Brown, Morris, Jaspal Kooner, S. Eyheramendy (7611197), Roberto Iacone, Samani Nilesh J, Fadi J Charchar, Shaw Hawkins S, Strazullo, Pasquale, Cheeseman, C, Elliott P, Strazzullo Pasquale, M. Brown (3020991), Ji Chen, Cheeseman, Chris (Christopher I.), Meena Kumari, Chambers, John, MD, Org, Elin, Anna Dominiczak, S. Evans (6370628), Dominiczak Anna, Iacone, R, Dobson, Richard J, Brunner, E, Margus Viigimaa, P. Elliott (1293702), Viigimaa, Margus, Chen Ji, Connell, John M., Farrall M, Eyheramendy, S, M. J. Caulfield (7602383), Connell, John M, O'Neill D, Eyheramendy, Susana, Chambers J, C. Cheeseman (7611572), Laan Maris, Newhouse Stephen J, Caulfield, Mark J, Ji, C, Doblado, Manuel, Shaw-Hawkins, S, Dominiczak, A. F., Ji C, G. Veldre (7602656), Lathrop, G Mark, Eyheramendy Susana, A. Onipinla (7602377), Cappuccio, Francesco P, M. Kumari (7602503), Kooner Jaspal, Dominiczak, Anna, Nilesh J Samani, Brown M, Chambers, J, Viigimaa M, Strazzullo, Pasquale, Connell JM, Howard, Philip, Ji, Chen, Kumari M, O'Neill, Deb   +241 more
core   +1 more source

Reply to 'The uric acid value of 4.8 mg/dl may not be an ideal prognostic threshold for cardiovascular disease mortality'.

, 2022
We have read with interest the letter by Dr Wang [1] commenting on our article ‘The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study’ [2].
Borghi C, Rivasi G, Masi S, Virdis A, Ungar A, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)   +5 more
core   +1 more source